Clinical trials: Vascular Bleeding
Intracerebral Hemorrhage, Motor Impairment
Fluoxetine for Motor Recovery After Acute Intracerebral Hemorrhage
This is a randomized, double-blind, placebo-controlled, multicenter clinical trial that will be carried out in Mexico. The purpose of this study is to test whether a 3-month treatment with fluoxetine enhances motor recovery in…
- Trial name
- FMRICH (NCT01737541)
- Testing
- Fluoxetine
- Where
- 4 sites in Mexico
- Volunteers
- 32 people
- Sponsor
- Universidad Autónoma de Aguascalientes
Subarachnoid Hemorrhage, Aneurysmal
Interest of Tissue Oxygen Pressure (PtiO2) Monitoring to Detect a Vasospasm Post Aneurysmal Subarachnoid Hemorrhage
Vasospasm is a current complication after aneurysmal subarachnoid hemorrhage and often and often associated with brain ischemia.
- Trial name
- O2-VASO (NCT03361722)
- Volunteers
- 10 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Atrial Fibrillation (AF)
PRO-AF 52: Monthly Primary-Care 12-Lead ECG Screening for Incident Atrial Fibrillation in Adults Aged ≥65 Years
This prospective, single-arm study will evaluate the feasibility and yield of monthly, in-clinic 12-lead electrocardiogram (ECG) screening performed at affiliated Family Health Centers (Aile Sağlığı Merkezleri; ASMs) in Ordu…
- Trial name
- PRO-AF 52 (NCT07438054)
- Testing
- Monthly 12-lead ECG
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Kotyora Family Medicine Health Management and Education Association
Gastro Intestinal Bleeding, Ischaemic Heart Diseases
Gastrointestinal Bleeding is Blood Loss in the Digestive Tract, Classified as Upper or Lower. Ischemic Heart Disease is Due to Blocked Heart Arteries. Antiplatelet Drugs Help Prevent Heart Attacks But Increase GI Bleeding Risk, Especially When Used Together as Dual Therapy.
Gastrointestinal bleeding is blood loss in the digestive tract, classified as upper or lower. Ischemic heart disease is due to blocked heart arteries.
- Conditions
- Gastro Intestinal Bleeding, Ischaemic Heart Diseases, Antiplatelet Drugs, Antiplatelet Drug-related Gastrointestinal Injury
- Trial name
- NCT07125651
- Volunteers
- 112 people
- Sponsor
- Assiut University
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Ultra-early STatin in Patients With Aneurysmal subaRachnoid Hemorrhage (Ue-STAR)
A researcher-initiated and conducted multicenter, randomized controlled trial aimed at evaluating the efficacy and safety of ultra-early statin therapy in the treatment of acute aneurysmal subarachnoid hemorrhage (aSAH).
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Aneurysmal Subarachnoid Hemorrhage, Hemorrhage, Aneurysmal Subarachnoid
- Trial name
- Ue-STAR (NCT06559072)
- Testing
- Atorvastatin
- Where
- China
- Sponsor
- The George Institute
Venous Thromboembolism
A Comparison of Extended Versus Conventional Duration of Enoxaparin Prophylaxis (i.e., Preventive Treatment) for Venous Thromboembolism (VTE, i.e., Blood Clots in the Veins) and Bleeding Event Risk in a Population With Acute Medical Illness
Venous Thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with an increase in risk of mortality and long-term disability and is a major contributor to global disease burden.
- Trial name
- NCT05819112
- Where
- United States
- Volunteers
- 14,799 people
- Sponsor
- Sanofi
Atrial Fibrillation, Stroke
Left Atrial Appendage Occlusion Study II
A pilot, multicentre randomized controlled study of surgical left atrial occlusion (LAA) in 50 patients with atrial fibrillation/flutter undergoing cardiac surgery requiring cardiopulmonary bypass with additional risk factors for…
- Trial name
- LAAOSII (NCT00908700)
- Testing
- Surgical occlusion of the left atrial appendage, Best medical practice
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Population Health Research Institute
Intracerebral Hemorrhage
Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage
This trial is a phase IIa human clinical study, in which 60 patients with intracerebral hemorrhage (ICH) at basal ganglion or thalamus within 6 h after onset will be enrolled.
- Trial name
- NCT05434065
- Testing
- Celecoxib 200mg
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Atrial Fibrillation, Stroke
CHAMPION-AF Clinical Trial
The primary objective of this study is to determine if left atrial appendage closure (LAAC) with the WATCHMAN FLX device is a reasonable alternative to non-vitamin K oral anticoagulants in patients with non-valvular atrial…
- Conditions
- Atrial Fibrillation, Stroke, Bleeding
- Trial name
- CHAMPION-AF (NCT04394546)
- Testing
- WATCHMAN FLX LAAC Device, Non-Vitamin K Oral Anticoagulant
- Where
- 141 sites in United States, Australia and 14 more
- Volunteers
- 3,000 people
- Sponsor
- Boston Scientific Corporation
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility…
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke
- Trial name
- INTENT (NCT07521930)
- Testing
- INTENT Neural Interface System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Intraoperative Bleeding
The Efficacy of the Administration of Fibrinogen in Liver Transplantation
Objective: To evaluate the efficacy of preoperative administration of fibrinogen in liver transplantation by maintaining a preoperative plasma level equal to 2.9 g / L compared with placebo, reflecting a reduction in the number…
- Trial name
- FibstudLT (NCT01539057)
- Testing
- Fibrinogen, Saline
- Where
- 4 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Brain Aneurysms
Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage
The purpose of the study is to investigate if briefly stopping blood flow to the patient's leg will lead to the patient's body being better able to tolerate possible decreased blood flow to regions of the brain which otherwise…
- Trial name
- RIPC-SAH (NCT02381522)
- Testing
- Remote Ischemic Pre-conditioning
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Loma Linda University
Aneurysmal Subarachnoid Hemorrhage
The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage
The purpose of this phase II study is to further assess the safety of tiopronin in aneurysmal subarachnoid hemorrhage(aSAH) patients in order to obtain preliminary data on the efficacy of tiopronin versus placebo in reducing…
- Trial name
- NCT01095731
- Testing
- Tiopronin
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- E. Sander Connolly
Stroke, Stiffness of Right Hand, Not Elsewhere Classified
Relationship Between Upper Extremity' Viscoelastic Properties and Functionality in Subacute Stroke
In stroke patients, the shoulder-upper extremity complex is affected and reduces independence and quality in activities of daily living.
- Conditions
- Stroke, Stiffness of Right Hand, Not Elsewhere Classified, Muscle Tone Abnormalities, Functional; Bleeding
- Trial name
- NCT05920837
- Testing
- MyotonPRO, Box and Block Test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- University of Gaziantep
Henoch-Schoenlein Purpura
Efficacy of Steroid Versus Steroid Plus Cyclophosphamide for Severe Henoch-Schoenlein Purpura
Henoch-Schonlein purpura is a leucocytoclastic systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA.
- Trial name
- NCT00190229
- Testing
- Cyclophosphamide
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Hemorrhage, Intracranial Arteriovenous Malformations
MRI for the Early Evaluation of Acute Intracerebral Hemorrhage
What happens in the borderzone of a cerebral hemorrhage remains widely onknown and furhter the best timing for doing MR to look for vascular pathology in cerebral hemorrhage has not yet been determined.
- Conditions
- Cerebral Hemorrhage, Intracranial Arteriovenous Malformations, Intracranial Hemorrhage, Hypertensive, Brain Neoplasms
- Trial name
- NCT01689402
- Testing
- MRI Scan with the specified sequences below:
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Atrial Fibrillation (AF)
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly.
- Trial name
- ROXI-ATLAS (NCT07175428)
- Testing
- REGN7508, REGN9933, Apixaban
- Where
- 89 sites in United States, Argentina and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Regeneron Pharmaceuticals
Subarachnoid Hemorrhage
HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients
The purpose of this study is to determine whether 7.2% NaCl in 6% hydroxyethyl starch will lower intracranial pressure (ICP) in SAH-patients with normal or moderately elevated ICP in a placebo controlled study, and to describe…
- Trial name
- NCT00199706
- Testing
- 7.2% NaCl in 6% hydroxyethyl starch solution
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Hypotension,Controlled
Correlation Analysis of the Effects of Management Pressure Goals and Control Volume Goals in Patients in Spinal Surgery
The investigators study 160 patients undergoing spinal surgery.Participants will be randomly divided into study group and control group.The study group will receive controlled hypotension by nitroglycerin and be divided into 3…
- Trial name
- NCT03917004
- Testing
- Nitroglycerin
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Liang Bing