Clinical trials: Variceal Bleeding
Gastric Varices Bleeding, Cirrhosis
EUS-Guided Coil and Glue vs Glue Injection for Bleeding Gastric Varices in Cirrhosis
Gastric variceal bleeding is a life-threatening complication of portal hypertension in patients with cirrhosis and is associated with significant morbidity and mortality.
- Trial name
- NCT07855913
- Testing
- EUS-guided Coil and Cyanoacrylate Glue Injection, Endoscopic Cyanoacrylate Glue Injection
- Where
- 2 sites in United States, India
- Volunteers
- 110 people
- Sponsor
- Medanta, The Medicity, India
Liver Cirrhosis, Refractory Ascites
Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study
Transjugular intrahepatic portosystemic shunt (TIPS) creation is an established minimally invasive treatment for complications of portal hypertension such as refractory ascites and variceal bleeding.
- Conditions
- Liver Cirrhosis, Refractory Ascites, Variceal Bleeding, Portal Hypertension
- Trial name
- FLIGHT (NCT07470515)
- Testing
- Fiber-Optic Navigation System
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University Innsbruck
Acute Variceal Bleed
Comparative Efficacy of Various Non-invasive Methods in Assessing Response to Beta-blockers as Secondary Prophylaxis for Acute Variceal Bleed.
Portal hypertension (PH) is a common complication of chronic liver disease and a major cause of morbidity and mortality in cirrhotic patients.
- Trial name
- NCT05166317
- Testing
- This is an observational study
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Esophageal Varices
Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders
The goal of this clinical trial is to evaluate whether carvedilol plus endoscopic variceal ligation (EVL) is more effective for the primary prevention of esophageal variceal bleeding than carvedilol alone in carvedilol…
- Trial name
- CVL-NR (NCT06594783)
- Testing
- Carvedilol plus endoscopic variceal ligation, Carvedilol alone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastric Varices
Primary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal bleeding.
- Trial name
- NCT02468180
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Portal Hypertension, Varice Bleed
Carvedilol vs. Propranolol in Second Prophylaxis of Variceal Bleeding
This randomized controlled trial was conducted to evaluate the efficacy and safety of carvedilol versus propranolol, combined with routine endoscopic treatment, in the secondary prophylaxis of variceal bleeding in patients with…
- Conditions
- Portal Hypertension, Varice Bleed, Cirrhosis, Liver
- Trial name
- NCT05651789
- Testing
- Carvedilol, Propranolol
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Terlipressin Adverse Reaction
Terlipressin Infusion in Variceal Hemorrhage
Randomized, open label study of intravenous terlipressin infusion vs. bolus for the treatment of variceal hemorrhage. 24 hour regimen consisting of intravenous terlipressin will be used either at a rate of 0.5mg/hour or 2mg bolus…
- Trial name
- TT (NCT04028505)
- Testing
- Terlipressin Injectable Product
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Aga Khan University
Portal Vein Thrombosis, Anticoagulant Therapy
Direct Oral Novel Anticoagulants for Patients With High-risk Gastroesophageal Variceal Bleeding and Portal Vein Thrombosis
This study aims to explore the safety and efficacy of oral administration of a novel anticoagulant (rivaroxaban) in patients with cirrhosis accompanied by high-risk esophagogastric variceal bleeding and portal vein thrombosis…
- Conditions
- Portal Vein Thrombosis, Anticoagulant Therapy, Variceal Bleeding
- Trial name
- NCT07602062
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Shanghai Zhongshan Hospital
Variceal Hemorrhage
Clinical Evaluation of Hemospray in Hemostasis of Active Variceal Bleeding
The objective of this study is to assess the effectiveness of Hemospray in achieving initial hemostasis and decreased rate of re-bleeding in patients of acute variceal bleeding.
- Trial name
- NCT01783899
- Testing
- Hemospray
- Where
- 2 sites in Belgium, Egypt
- Volunteers
- 30 people
- Sponsor
- Theodor Bilharz Research Institute
Liver Cirrhosis
Long-term Efficacy and Safety of LSD Versus TIPS for Cirrhotic Portal Hypertension Bleeding and Hypersplenism
This study aims to compare two treatments for cirrhotic portal hypertension with acute esophagogastric variceal bleeding and hypersplenism: laparoscopic splenectomy and azygoportal disconnection (LSD) and transjugular…
- Trial name
- LSD、TIPS (NCT07490405)
- Testing
- LSD, TIPS
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Northern Jiangsu People's Hospital
Cirrhosis, Variceal Bleeding
EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment
This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
- Trial name
- NCT00966082
- Testing
- endoscopic band ligation, endoscopic band ligation+Propranolol
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Korea University
Liver Cirrhosis, Esophageal and Gastric Varices
Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails
To observe and access the Effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients with acute variceal bleeding.
- Conditions
- Liver Cirrhosis, Esophageal and Gastric Varices, Hemorrhage
- Trial name
- CER:T (NCT02311608)
- Testing
- Terlipressin, Usual Dose Somatostatin/Octreotide, High Dose Somatostatin/Octreotide
- Where
- China
- Volunteers
- 1,320 people
- Sponsor
- Shanghai Zhongshan Hospital
Variceal Bleeding, Cirrhosis
A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis
The value of banding ligation plus beta blocker in the prophylaxis of first episodes of variceal bleeding has not yet been evaluated.
- Trial name
- NCT00921349
- Testing
- Ligation of varices, Nadolol
- Volunteers
- 140 people
- Sponsor
- National Science and Technology Council, Taiwan
Upper Gastrointestinal Bleeding
PuraStat® Combined With Adrenaline Versus Standard of Care in Upper Gastrointestinal Bleeding
PuraStat® is a novel gel that offers several advantages over traditional hemostatic powders. Its transparency allows for continuous visualization of the bleeding site, and it can be applied in narrow spaces or in combination with…
- Trial name
- NCT06896409
- Testing
- PuraStat® combined with Adrenaline, Standard of Care
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Tallaght University Hospital
Gastroesophageal Varices Hemorrhage, Colorectal Cancer
Oxaliplatin-induced Portal Hypertension
Oxaliplatin has been used as the first choice for the adjuvant chemotherapy of colorectal cancer and it has significantly improved the outcomes in patients with colorectal cancer.
- Conditions
- Gastroesophageal Varices Hemorrhage, Colorectal Cancer, Received Oxaliplatin-based Chemotherapy
- Trial name
- NCT04524676
- Testing
- Individualized Treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Zhongshan Hospital
Non-variceal Upper Gastrointestinal Bleeding
Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding
The aim of the study is to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.
- Trial name
- NCT03980496
- Testing
- Omeprazole
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Bialystok
Cirrhosis, Hypertension, Portal
Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding
This is a prospective, double blind controlled trial in which patients with esophagic variceal bleeding treated with standard therapy (endoscopic variceal ligation(EVL) + B-blockers), will be randomized to receive statins or…
- Conditions
- Cirrhosis, Hypertension, Portal, Bleeding Esophageal Varices, Portal Vein Thrombosis
- Trial name
- NCT01095185
- Testing
- Simvastatin
- Where
- 15 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Juan A. Arnaiz
Liver Cirrhosis
To Study the Hemodynamic Response of Early Addition of Carvedilol to Terlipressin in Acute Variceal Bleed in Child's B and C Cirrhosis
Management of Acute variceal bleeding includes endoscopic variceal ligation (EVL) along with vasoactive agents. Inspite of successful hemostasis, this is associated with high variceal rebleeding (VRB) in Child B and C cirrhosis…
- Trial name
- NCT05699824
- Testing
- Carvedilol Day2, Standard Medical Treatment, Carvedilol Day6
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure
Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed
Acute portal hypertension, as measured by rapid rise in hepatic venous pressure gradient (HVPG) can lead to further dreaded complications, including acute variceal bleeding (AVB) AVB: 6-week mortality rates of around 15-20% in…
- Trial name
- NCT06815770
- Testing
- Terlipressin Injectable Product
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
CIRRHOSIS, ESOPHAGEAL VARICES
PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES?
This prospective randomized controlled trial will compare endoscopic band ligation (EBL) with propranolol and EBL alone in primary prophylaxis of variceal bleeding among cirrhotic patients with high-risk varices.
- Trial name
- NCT01893541
- Testing
- ENDOSCOPIC BAND LIGATION, PROPRANOLOL, a multiband ligation device
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo