Clinical trials: Vaping Behaviors
Smoking Cessation
Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes
This single-group, small-scale, open-label study (N= 25 to 50) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- BuZonE (NCT04388319)
- Testing
- Zonisamide, Bupropion, Halo G6 e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Tobacco Use Disorder, Nicotine Dependence
Young Adult Tobacco/Nicotine and Cannabis Co-use
The goal of this project is to better understand the relationship between tobacco/nicotine and cannabis using behavioral economics during a tobacco/nicotine quit attempt.
- Trial name
- YouthCAT (NCT06239350)
- Testing
- Counseling, Contingency management, Text-based support
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Implementation Science, Engagement, Patient
Parents Helping Parents for Youth Vaping Cessation
The goal of this randomized controlled study is to test if this new intervention works to help adolescents quit vaping. A key feature of the program is the use of peer support for parents, delivered by trained parent coaches.
- Conditions
- Implementation Science, Engagement, Patient, E Cigarette Use, Peer Support
- Trial name
- PhP-VX (NCT07207850)
- Testing
- Parents Helping Parents program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Nebraska
Electronic Cigarette
Nicotine Pharmacokinetic in Blood and Analysis of Exhaled Breath After E-cigarette Smoking.
Electronic or e-cigarettes are battery-powered devices that deliver vapor which may be inhaled in the manner tobacco is smoked. The e-liquid is usually a solution containing propylene glycol and/or vegetable glycerin, nicotine…
- Trial name
- VAPexp'Air (NCT03573154)
- Testing
- administration of the liquid 1 and then the liquid 2, administration of the liquid 2 and then the liquid 1
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Smoking, E-cigarette Use
Impact of New Product Standards for JUUL Among Dual JUUL/Combusted Cigarette Users
To date the majority of experimental tobacco regulatory science has focused specifically on the impact of possible tobacco product standards (e.g.
- Conditions
- Smoking, E-cigarette Use, Cigarette Smoking
- Trial name
- NCT04179617
- Testing
- 5% nicotine content JUUL pod, 3% nicotine content JUUL pod
- Sponsor
- Duke University
Nicotine Administration & Dosage, E-cigarettes
Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes
This is an observational, crossover design that will examine the pharmacokinetics and pharmacodynamics of impact of smoking tobacco cigarettes or vaping the JUUL electronic cigarette.
- Conditions
- Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid
- Trial name
- NCT04053868
- Testing
- JUUL, Tobacco
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cigarette Smoking-Related Carcinoma
Electronic Cigarette Use During Pregnancy
Aim 1: To compare the overall toxicant exposure in pregnant women who use electronic cigarettes (e-cigs, vapor, e-liquid, e-juice, vape, vaping devices) compared to women who smoke conventional cigarettes. Aim 2.
- Trial name
- NCT03480373
- Where
- 6 sites in United States
- Volunteers
- 182 people
- Sponsor
- UConn Health
Vaping, Vaping Teens
Behavioral Intervention for Youth to Promote Vaping Cessation
This study will test the hypothesis that the QuitVaping (QV) intervention and additional texting support will improve nicotine abstinence rates in adolescents as compared to Enhanced Usual Care (EUC: education about nicotine…
- Conditions
- Vaping, Vaping Teens, Nicotine Dependence
- Trial name
- VIA (NCT06765291)
- Testing
- QuitVaping, This is Quitting (TIQ)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Vaping Behaviors, Message Exposure
A Text Messaging Trial to Test Vaping Health Messages Optimized to Young Adults' Vaping Status
The goal of this study is to examine if e-cigarette education messages delivered using a source and presentation tailored to one's vaping status influences young adults' vaping behaviors.
- Conditions
- Vaping Behaviors, Message Exposure, Young Adults
- Trial name
- NCT07038317
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Vaping
Point-of-Care Ultrasound (POCUS) Findings and Impact on Vaping
Vaping has emerged as a prominent public health crisis in recent years. In 2023, the National Youth Tobacco Survey found that more than 2.1 million adolescents endorse vaping, with 25% of those endorsing daily use.
- Trial name
- NCT06335329
- Testing
- Discussion of point-of-care ultrasound lung findings
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Use Disorder
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
- Trial name
- NCT05932745
- Testing
- E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
Healthy Smokers, Smoking Cessation
Efficacy and Safety of an Electronic Nicotine Delivery Device (E-Cigarette) Without Nicotine Cartridges
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01194583
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Catania
Vaping
Influencer Marketing and Adolescent E-cigarette Use
Adolescents (N = 700) participated in the online survey-based randomized experiment focused on understanding youth perceptions of e-cigarette influencer marketing on social media.
- Trial name
- NCT07420842
- Testing
- Youth Perceptions of Influencer Age and Fitness Contexts in E-Cigarette Marketing
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Southern California
Vaping, E Cig Use
A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach
The goal of this randomized controlled trial is to evaluate a psychosocial school-based hybrid intervention which includes traditional classroom sessions and online e-learning modules to reduce risk of vaping and prescription…
- Conditions
- Vaping, E Cig Use, Prescription Drug Misuse
- Trial name
- NCT07162155
- Testing
- School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Christopher Williams
Cigarette Smoking
Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)
This project will address a growing public health concern, namely, the health risks or benefits of e-cig use relative to cigarette smoking.
- Trial name
- NCT03750825
- Testing
- NIDA Standard Research E-cigarette (SREC)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cardiovascular Risk Factor, Diabetes Mellitus, Type 2
Metabolic Syndrome in Diabetic Smokers Using Cigarettes & Combustion-Free Nicotine Delivery Systems
Very little is known about the impact of combustion-free nicotine delivery systems (C-F NDS) on cardiovascular risk factors in T2DM patients who smoke.
- Trial name
- DIASMOKE (NCT04231838)
- Testing
- TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS)
- Where
- United Kingdom
- Volunteers
- 576 people
- Sponsor
- Eclat Srl.
Vaping
To Vape or Not to Vape
The overall goal of this study is to increase knowledge of vaping and its associated risks. This study will find the patterns of vaping, and how it all started among adolescents.
- Trial name
- NCT05240027
- Testing
- Vape use survey
- Where
- United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Cigarette Smoking, Nicotine Vaping
Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study
This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.
- Trial name
- MUSC-R 3a (NCT06456671)
- Testing
- All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Heated tobacco products at 1/2 market price.
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Virginia Polytechnic Institute and State University
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont