Clinical trials: Valvular Disease
Acute Kidney Injury
Effect of Erythropoietin on the Incidence of Acute Kidney Injury Following Complex Valvular Heart Surgery
Acute kidney injury (AKI) frequently occurs after cardiac surgery using cardiopulmonary bypass (CPB). Recombinant human erythropoietin (rHuEPO) is known to provide organ protection against ischemia-reperfusion injury through its…
- Trial name
- NCT01758861
- Testing
- EPO group
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Yonsei University
Aortic Stenosis, Aortic Valve Stenosis
Angiotensin Receptor Blockers in Aortic Stenosis
This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.
- Trial name
- ARBAS (NCT04913870)
- Testing
- Angiotensin Receptor Blockers
- Where
- 2 sites in Canada, Denmark
- Volunteers
- 144 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Atrial Fibrillation
SPARK: Safety Study of Pradaxa in Atrial Fibrillation Patients by Regulatory Requirement of Korea
This is a prospective, non-interventional, open-label, multi-centre study. It will provide additional safety information of Pradaxa in Korean patients with non-valvular AF in clinical settings.
- Trial name
- NCT01774370
- Testing
- Pradaxa (Dabigatran etexilate mesilate)
- Where
- South Korea
- Volunteers
- 3,182 people
- Sponsor
- Boehringer Ingelheim
Atrial Fibrillation, Percutaneous Coronary Intervention
Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)
The main objective of this study is to compare a Dual Antithrombotic Therapy (DAT) regimen of 110mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (110mg dabigatran etexilate (DE) DAT) and 150mg dabigatran etexilate…
- Trial name
- NCT02164864
- Testing
- Dabigatran Etexilate 110mg, Warfarin 3mg, Aspirin
- Where
- 421 sites in United States, Argentina and 39 more
- Volunteers
- 2,725 people
- Sponsor
- Boehringer Ingelheim
Valvulopathy
Valvular Microbiota and Valvulopathy
Few teams in the world can reliably analyze tissue microbiota. In this regard, the present group has unique expertise in the analysis of blood and tissue microbiota, the first to describe in 2011.
- Trial name
- MICROVALV (NCT06407128)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Valvular Disease, Valvular Heart Disease
Epidemiology and Long-term Outcome of Patients With VHD
Valvular heart diseases are significant problem in Polish population. Coexistence of coronary artery disease in patients with VHD increases the risk of death and affects further therapeutic strategy.
- Conditions
- Valvular Disease, Valvular Heart Disease, Aortic Valve Stenosis, Mitral Insufficiency and Aortic Stenosis
- Trial name
- BIA-WAD (NCT04527367)
- Testing
- Innovative medical technologies in invasive cardiology and cardiac surgery
- Where
- Poland
- Volunteers
- 2,500 people
- Sponsor
- Medical University of Bialystok
Coronary Artery Disease, Valvular Heart Disease
Efficacy of Sternum Guard in Post Cardiac Surgery Patient
This is a single-center, single-blind, randomized parallel superiority trial comparing two groups; Sternum GuardTM as the treatment arm and Bone Wax as the active control group.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Congenital Heart Disease in Adolescence, Post Operative Wound Infection
- Trial name
- NCT05229276
- Testing
- Sternum Guard, Bone Wax
- Where
- Indonesia
- Volunteers
- 414 people
- Sponsor
- Universitas Indonesia
Aortic Valve Insufficiency, Aortic Valve Regurgitation
Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis
Collect data on the safety and clinical performance of the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis
- Conditions
- Aortic Valve Insufficiency, Aortic Valve Regurgitation, Aortic Valve Stenosis, Aortic Valve Incompetence
- Trial name
- NCT05902897
- Testing
- Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis.
- Where
- 3 sites in Brazil
- Volunteers
- 913 people
- Sponsor
- Braile Biomedica Ind. Com. e Repr. Ltda.
Atrial Fibrillation
Phase 2 Study of the Safety, Tolerability and Pilot Efficacy of Oral Factor Xa Inhibitor Betrixaban Compared to Warfarin
Prevention of stroke in patients with atrial fibrillation (AF). Hypothesis: In patients with non-valvular AF, orally administered betrixaban will provide similar or better efficacy and safety than warfarin and it will offer the…
- Trial name
- EXPLORE-Xa (NCT00742859)
- Testing
- betrixaban, Warfarin
- Where
- 21 sites in United States, Canada
- Volunteers
- 508 people
- Sponsor
- Portola Pharmaceuticals
Atrial Fibrillation
Efficacy and Safety of Rivaroxaban for the Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation
This is a clinical study evaluating the efficacy and safety of rivaroxaban for stroke prevention in patients with atrial fibrillation (originally described in Japanese).
- Trial name
- NCT00494871
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Warfarin
- Where
- 165 sites in Japan
- Volunteers
- 1,280 people
- Sponsor
- Bayer
Tricuspid Regurgitation
Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment
The field of transcatheter tricuspid valve replacement (TTVR) is rapidly emerging and data on this topic are scarce. Particularly, little is known about which patients are at greatest risk of procedural complications, such as the…
- Trial name
- TRIPLACE (NCT06033274)
- Testing
- Transcatheter Tricuspid Valve Replacement
- Where
- 31 sites in United States, Canada and 6 more
- Volunteers
- 800 people
- Sponsor
- Montefiore Medical Center
Heart Diseases, Heart Diseases, Ischemic
Upper Extremity Elevation and Lungfunction After Open Heart Surgery
The purpose of this study is to assess if arm elevation, with or without simultaneous deep breathing, affects oxygen saturation and lung function on patients two to four days after open heart surgery.
- Conditions
- Heart Diseases, Heart Diseases, Ischemic, Heart Disease, Valvular
- Trial name
- NCT05278819
- Testing
- upper extremity elevation, upper extremity elevation with deep breathing
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Michael Reinhart
Atrial Fibrillation, Anticoagulant-induced Bleeding
Baseline Concentration of Direct Oral Anticoagulant and Incidence of Adverse Event Measure And See (MAS)
The MAS Study is an observational, multicentre, prospective cohort study in Non valvular Atrial fibrillation (NVAF) patients treated with one of the direct oral anticoagulants (DOACs) available in Italy for NVAF patients.
- Trial name
- MAS (NCT03803579)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Arianna Anticoagulazione Foundation
Valvular Heart Disease, Rheumatic Heart Disease
Echocardiographic Screening of Pregnant Women During Antenatal Care
Non-obstetrical drivers of adverse pregnancy outcomes are underappreciated. Latent structural heart disease may account for a substantial proportion of adverse pregnancy outcomes in low-resource settings.
- Conditions
- Valvular Heart Disease, Rheumatic Heart Disease, Pregnancy Complications
- Trial name
- NCT04936815
- Testing
- Transthoracic echocardiography
- Where
- 2 sites in Nepal, Switzerland
- Volunteers
- 9,000 people
- Sponsor
- Thomas Pilgrim
Prosthetic Valve Endocarditis
Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify…
- Trial name
- EndEOTEP (NCT05989152)
- Testing
- FDG-PET at the end of treatment for IE
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Structural Heart Disease
Pressure-Volume Loop Assessment in Valvular Heart Disease
The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD).
- Conditions
- Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- VHD-PV-loop (NCT07112391)
- Testing
- Observational Invasive Hemodynamic Assessment
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Atrial Fibrillation
Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)
1600 AF patients receiving Pradaxa or VKA for stroke prevention will be followed up for 12 months in quarterly visits. Prescriptions, adverse events and (if applicable) reasons for definitive treatment discontinuation will be…
- Trial name
- NCT02240667
- Testing
- Dabigatran etexilate, Vitamin K antagonists
- Where
- Germany
- Volunteers
- 1,506 people
- Sponsor
- Boehringer Ingelheim
Non-valvular Atrial Fibrillation, Elderly, Frailty, Thrombosis
The Impact of Frailty on Thrombosis of Elderly Patients With NVAF （FTE-NVAF）
This study aims to investigate the use of anticoagulants in elderly patients with non-valvular atrial fibrillation (NVAF) and the incidence of frailty in elderly patients with NVAF.
- Trial name
- NCT04476147
- Testing
- Diagnostic Test: CHA2DS2-VASc, HAS-BLED and Fried Scale.
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Friendship Hospital
Valvular Heart Disease Stenosis and Regurgitation
Natriuretic Peptides as a Prognostic and Risk Stratification Tool in Assessment of Valvular Heart Disease
NPs can be used To detect subset of asymptomatic with subtle LV dysfunction for further evaluation and earlier referral for intervention and its correlation with echocardiographic finding.
- Trial name
- NCT05439369
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University