Clinical trials: Vagus Nerve Stimulation, open to volunteers
Persistent Post Traumatic Headache
nVNS, CBD, and SoC for Persistent Post-Traumatic Headache
Do cannabidiol (CBD) or vagus nerve stimulation reduce the frequency of persistent post-traumatic headache more than traditional oral headache medications?
- Trial name
- NCT07624279
- Testing
- Non-Invasive Vagus Nerve Stimulation, Cannabidiol, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- American Society of Pain and Neuroscience, Inc.
Burn Injury
Non-Invasive Vagus Nerve Stimulation in Burn Patients During Dressing
This study will evaluate the effects of non-invasive vagus nerve stimulation on pain, anxiety, and quality of life in burn patients during the dressing process. Participants will be randomly assigned to one of three groups.
- Trial name
- NCT07566910
- Testing
- Non-Invasive Vagus Nerve Stimulation, Standard Dressing Care
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Fenerbahce University
Alzheimer Disease (AD)
Alzheimer's Disease Treated With Vagus Nerve Stimulation
The goal of this clinical trial is to evaluate the safety and efficacy of vagus nerve stimulation (VNS) for treating Alzheimer's disease (AD) in patients aged 50-80 years with mild cognitive impairment to moderate Alzheimer's…
- Trial name
- Advant (NCT06923007)
- Testing
- Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Beijing Municipal Administration of Hospitals
Depression, Epilepsy
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the…
- Trial name
- NCT06038929
- Testing
- Vagal nerve stimulant
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Mayo Clinic
Disorder of Consciousness
Vagal Nerve Stimulation to Treat Disorders of Consciousness
This interventional study aims to assess the clinical efficacy of transcutaneous auricular vagal nerve stimulation (taVNS) against sham stimulation on the recovery of consciousness in patients with disorders of consciousness.
- Trial name
- REVELATION (NCT07077135)
- Testing
- stimulated group
- Where
- 11 sites in Italy
- Volunteers
- 106 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Chronic Subjective Tinnitus
Efficacy Analysis of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Therapy in the Treatment of Chronic Subjective Tinnitus
The goal of this multicenter, randomized, double-blind clinical trial is to compare two treatments for adults with chronic subjective tinnitus.
- Trial name
- NCT07794462
- Testing
- taVNS Combined With TMNMT
- Where
- 6 sites in China
- Volunteers
- 444 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility Assisted Reproductive Technology
The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF
To assess the feasibility of taVNS on pregnancy outcomes of infertility subjects undergoing IVF, the primary aim of this trial will focus on encompassing recruitment, compliance, and preliminary engagement outcomes.
- Trial name
- NCT06742788
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Sleep
Non-invasive Vagus Nerve Stimulation and Sleep in Healthy Volunteers.
Participants will be chosen at random to receive a 30-minute stimulation of a specialized nerve (called a vagus nerve). The aim of this study is to determine whether a battery-operated portable device (current adjustable)…
- Trial name
- NCT06928441
- Testing
- Transcutaneous Pulsed Electrical Stimulation (Device: WL-2103A)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Alzheimer Disease
Implantable Vagus Nerve Stimulation Modulation of Coeruleus-Norepinephrine Network for Mild-Moderate AD Patients
A randomized controlled clinical study will be conducted in Xuanwu Hospital of Capital Medical University. This study initially explore the effect of selective vagus nerve(C fiber) stimulation on mild-to-moderate AD patients, in…
- Trial name
- NCT05575271
- Testing
- Vagus Nerve Stimulation Modulation of the Coeruleus-Norepinephrine Network
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Pain, Pain Perception
Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults
The goal of this clinical trial is to learn whether stimulating a nerve in the neck changes how much pain people feel. It also looks at whether this stimulation changes brain activity.
- Conditions
- Acute Pain, Pain Perception, Healthy Adult Participants
- Trial name
- NCT07827690
- Testing
- Active transcutaneous vagus nerve stimulation, Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- David A. Purger
Psychosocial Well-being, Neurocognitive Function
taVNS + CCT for Neurocognitive Rehab
The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood.
- Conditions
- Psychosocial Well-being, Neurocognitive Function, Cognitive Complaint, Cognitive Dysfunction
- Trial name
- NeuroHUB (NCT07517237)
- Testing
- taVNS, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Psychiatric Disorder
Pilot Study on the Acceptability of Auricular Vagus Nerve Neurostimulation in Adolescents
Non-suicidal self-injury (NSSI) are acts defined by the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders 5) as intentional and deliberate, occurring outside a psychotic state and directly causing moderate injury.
- Trial name
- NEUROMUTE (NCT06433583)
- Testing
- transcutaneous auricular vagal nerve stimulation
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Anterior Cruciate Ligament Injuries, Recovery Quality
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
Background: Arthroscopic anterior cruciate ligament reconstruction (ACLR) is a common orthopedic surgery. Postoperative pain, inflammatory response and opioid-related adverse events impair early recovery quality.
- Conditions
- Anterior Cruciate Ligament Injuries, Recovery Quality, Auricular Vagus Nerve Stimulation
- Trial name
- NCT07904949
- Testing
- Experimental-Active taVNS
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
Depressive Disorder, Bipolar Disorder
Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression
Invasive vagus nerve stimulation (VNS) is an approved treatment of treatment-resistant depression (TRD) in Europe and in USA. Because of the associated possible surgical complications as well as side effects, invasive VNS is…
- Trial name
- AddVNS (NCT07022171)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Obesity & Overweight
Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Lifestyle Intervention
This single-center, randomized, single-blind, sham-controlled pilot study aims to evaluate the adjunctive effect of transcutaneous auricular vagus nerve stimulation (taVNS) in overweight/obese patients who show a poor weight loss…
- Trial name
- NCT07630597
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Fibromyalgia
Auricular Neuromodulation in Veterans With Fibromyalgia
PENFS (percutaneous electrical nerve field stimulation) is an FDA-cleared acupuncture-like therapy applied to the external ear targeting several cranial nerve branches including the auricular branch of the vagus nerve to improve…
- Trial name
- PENFS (NCT06415591)
- Testing
- Percutaneous electrical nerve field stimulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Heavy Menstrual Bleeding
Delivering tAN to Reduce HMB: The LUNA Study
The LUNA study is a prospective, randomized, double-blind, sham-controlled, decentralized clinical trial in participants with heavy menstrual bleeding of no known structural cause.
- Trial name
- LUNA (NCT07326722)
- Testing
- Sparrow Link
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Spark Biomedical, Inc.
Obesity
Effect of Non-invasive Vagal Nerve Stimulation on Selected Outcomes in Central Obesity
Trans Cutanous Electric Nerve Stimulation of Auricular Vagus Nerve
- Trial name
- NVN-CO (NCT07341971)
- Testing
- Transcutanous Auricular vagus nerve stimulation
- Volunteers
- 60 people
- Sponsor
- Cairo University
Hemiplegia, Respiratory Function Loss
Effect of Transcutaneous Auricular Vagus Nerve Stimulation Application on Respiratory Functions in Stroke Patients
The purpose of this study is to evaluate the effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (TAVSS) in improving respiratory muscle strength and function in chronic stroke patients.
- Trial name
- TAVNS (NCT06793800)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Fenerbahce University
Postpartum Depression (PPD), Postpartum Anxiety
Investigation of TVNS Administration on Postpartum Mental Health
The aim of the study is to explore whether transcutaneous vagus nerve stimulation (tVNS) may be effective in preventing mood swings and depressive symptoms in the postpartum phase, as well as serving as a supplementary…
- Conditions
- Postpartum Depression (PPD), Postpartum Anxiety, Postpartum Sadness, Postpartum Blues
- Trial name
- NCT06682689
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen