Clinical trials: Vaginal Delivery
Postpartum Hemorrhage, High Risk Pregnancy
Tranexamic Acid for the Prevention of Blood Loss in High Risk Delivered Women
Postpartum hemorrhage and its complications are very well known causes for maternal mortality .Uterine atony is the most common cause for postpartum hemorrhage
- Conditions
- Postpartum Hemorrhage, High Risk Pregnancy, Tranexamic Acid, Third-Stage Postpartum Hemorrhage, With Delivery
- Trial name
- NCT04201951
- Testing
- Tranexamic acid injection, Glucose water 5%
- Where
- 2 sites in Iraq
- Volunteers
- 196 people
- Sponsor
- Hawler Medical University
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
Infertility, Pregnancy Related
The Impact of Vaginal Intercourse on Pregnancy Rates After Frozen Embryo Transfer
This study aims to evaluate whether allowing unprotected vaginal intercourse 24 hours after frozen embryo transfer will result in higher ongoing clinical pregnancy rates in comparison to having participants abstain from…
- Conditions
- Infertility, Pregnancy Related, IVF
- Trial name
- NCT03974295
- Testing
- Vaginal unprotected intercourse
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Pregnancy
Vaginal Progesterone to Reduce the Risk of Another Preterm Birth
This research study is being conducted at over 12 pregnancy research centers in the US. The study will compare an investigational treatment with a placebo (a treatment without medication).
- Trial name
- NCT00086177
- Testing
- 8% progesterone vaginal gel
- Where
- 45 sites in United States
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Juniper Pharmaceuticals, Inc.
Pregnancy
Efficacy of Labor Epidurals for Postpartum Tubal Ligation
The goal of this study is to evaluate the effect of continuous postpartum epidural saline infusion on the reactivation of labor epidurals for postpartum tubal ligation surgery following vaginal delivery.
- Trial name
- NCT02564016
- Testing
- Normal Saline Infusion, Capped Epidural
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Vaginal Delivery
Failed Epidural Anesthesia During Labor: Evaluation of Risk Factors and Outcome
Women requesting epidural analgesia will receive a bolus of intravenous infusion of lactated Ringer's solution before initiation of the procedure.
- Trial name
- NCT03129022
- Testing
- epidural anaesthesia
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Breastfeeding
Evaluation of Breastfeeding Success and Self-Efficacy in Mothers Giving Birth Via Vaginal Delivery or Cesarean Section
This cross-sectional observational study was conducted to compare breastfeeding success and breastfeeding self-efficacy levels of mothers who gave birth via vaginal delivery (spontaneous or via epidural analgesia) or cesarean…
- Trial name
- NCT05106634
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Vaginal Lesion
Abnormal Vaginal Flora and Vaginal Lesions at Delivery: is There a Relationship?
The main objective of this study is to assess whether the presence of abnormal vaginal flora (intermediate flora or vaginosis) is a risk factor for vaginal lesions at the time of delivery.
- Trial name
- NCT01822782
- Testing
- Bacteriological analysis of vaginal sample
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Obstetric Trauma, Perineum; Injury
The Effect of Perineal Wound Infection on the Anal Sphincter
Perineal injury following childbirth can result in complications such as wound infection. The perineum has closely related anatomical structures including the external genital organs and the anal triangle which contains the anal…
- Conditions
- Obstetric Trauma, Perineum; Injury, Perineal Infection, Anal Sphincter Injury
- Trial name
- NCT04480684
- Testing
- Three-dimensional Endoanal Ultrasound, Transperineal Ultrasound(multiplanar), The MolecuLight i:X: Bacterial autofluorescence camera
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Croydon Health Services NHS Trust
Morbid Obesity
Does Body Mass Index Impact the Outcome of Dural Puncture Epidural in Parturients Undergoing Normal Vaginal Delivery
Recently, the dural puncture epidural (DPE) technique has emerged as a novel method of labor analgesia. The DPE technique is a modification of the combined spinal epidural (CSE) technique, where a dural perforation is created…
- Trial name
- NCT04963452
- Testing
- Dural puncture epidural
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Birth, Anxiety
The Effect of Endorphin Massage Applied to Postpartum Women on Anxiety and Fatigue Levels
The postpartum period, especially in the first few weeks, can be a difficult period for mothers to adapt to the new situation of having a baby.
- Conditions
- Birth, Anxiety, Fatigue
- Trial name
- NCT06421233
- Testing
- massage
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Vulvar Cancer, Ovarian Cancer
Study of a Rapid Triadic Communication Intention Elicitation Intervention to Improve Supportive Oncology Care Delivery
The purpose of this study is to help test an idea designed to foster more supportive talk between providers (doctors or nurse practitioners), patients, and caregivers during an outpatient oncology appointment.
- Conditions
- Vulvar Cancer, Ovarian Cancer, Uterine Cancer, Vaginal Cancer
- Trial name
- PRECursOr (NCT05995860)
- Testing
- Intervention group triads
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Indiana University
Obstetric Labor, Premature
Vaginal Indomethacin for Preterm Labor
Indometacin is a cyclooxygenase agent from the NSAID family that has been used to treat preterm contractions since the 70's by preventing the synthesis of prostaglandins.
- Trial name
- TOCOMED (NCT04404686)
- Testing
- Indomethacin, Nifedipine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Delivery Problem, Cervix; Pregnancy
Effects of Systematic Cervical Exam Training on Labor and Delivery Care
All physicians, nurses, and nurse midwives working on Labor and Delivery will be required to complete cervical exam simulation training.
- Conditions
- Delivery Problem, Cervix; Pregnancy, Pregnancy Related
- Trial name
- NCT04421768
- Testing
- cervical exam training
- Where
- United States
- Volunteers
- 1,125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Childbirth Education, Birth Beliefs
Effect of Pecha Kucha-Based Normal Birth Education on Birth Beliefs and Birth Preferences Among Pregnant Women Considering Elective Cesarean Section
This randomized controlled trial was conducted to evaluate the effect of Pecha Kucha-based normal birth education on birth beliefs and mode of birth preferences among primiparous pregnant women considering elective cesarean…
- Conditions
- Childbirth Education, Birth Beliefs, Elective Cesarean Section
- Trial name
- NCT07657663
- Testing
- Pecha Kucha-Based Normal Birth Education, Traditional Normal Birth Education
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Cesarean Section Rates
Reducing Cesarean Section Rates and Enhancing Vaginal Delivery in Greece: a Stepped-Wedge Randomized Controlled Trial
It is becoming increasingly apparent that there is an urgent need to systematically investigate the rising cesarean section (CS) rates in Greece and develop interventions to substantially reduce these rates.
- Trial name
- ENGAGE (NCT04504500)
- Testing
- HSOG guidelines application, Interactive workshops and courses, Feedback through follow-up meetings
- Where
- Greece
- Volunteers
- 6,029 people, healthy volunteers welcome
- Sponsor
- Hellenic Society of Obstetrics and Gynecology
Indicated for Pelvic Radiotherapy, Vaginal Rehabilitation, and Alleviation of Late Toxic Reactions in the Vagina
Vaginal Function Exercisers and Vaginal Dilation Irrigation Drug Administration Tubes Are Used for Vaginal Rehabilitation Therapy in Pelvic Radiotherapy
Gynecological pelvic tumors primarily include ovarian cancer, cervical cancer, and endometrial cancer. Radiotherapy (RT) is one of the key treatment modalities for gynecological tumors.
- Trial name
- Exerciser (NCT07473271)
- Testing
- Vaginal exerciser and vaginal dilator with irrigation tube
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Peking Union Medical College Hospital
Scar; Previous Cesarean Section, Vaginal Birth After Cesarean
University of North Carolina-Healthwise Partnership Project on Birth Options Decision Aid
This is pilot quasi-experimental study of women with one or two prior cesarean deliveries who are now pregnant and eligible for a trial of labor after cesarean delivery, to assess whether a decision aid, providing knowledge about…
- Conditions
- Scar; Previous Cesarean Section, Vaginal Birth After Cesarean, Decision Making, Shared
- Trial name
- B-READY (NCT04053413)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Perineal Trauma, Pelvic Floor Dysfunction
Pelvic Floor Training Program and Perineal Trauma During Vaginal Birth
This study aims to determine whether a structured pelvic floor muscle training program during pregnancy can reduce perineal trauma during vaginal birth.
- Conditions
- Perineal Trauma, Pelvic Floor Dysfunction, Labor Complications, Pelvic Floor Muscle Training
- Trial name
- PFTP (NCT07292948)
- Testing
- Pelvic Floor Muscle Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mehmet Incebıyik
Bacterial Vaginosis
Safety and Efficacy of a Vaginally Administered Probiotic Lactobacilli Delivery System.
The purpose of this study is to assess the safety and the efficacy of vaginally administered probiotic lactobacilli in combination with antibiotic therapy (metronidazole) in women with microbiologically defined bacterial…
- Trial name
- NCT00752193
- Testing
- Probiotic lactobacilli
- Where
- Belgium
- Volunteers
- 206 people
- Sponsor
- University Ghent