Clinical trials: Vaccines
Influenza Vaccine
Intradermal Versus Intramuscular Trivalent Influenza Vaccine in Adult Solid Organ Transplant Recipients
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia and contribute to the development of rejection.
- Trial name
- NCT01180699
- Testing
- Influenza vaccine: Vaxigrip or Fluviral and Intanza
- Where
- Canada
- Volunteers
- 229 people
- Sponsor
- University of Alberta
Immunization, DTaP Vaccine
Comparison of Immunization Quality Improvement Dissemination Study
Dissemination research examines the processes and factors that lead to widespread use of evidence-based interventions. There are several theories on how to best minimize the perceived and actual burdens on practitioners…
- Conditions
- Immunization, DTaP Vaccine, Hepatitis B Vaccine, MMR Vaccine
- Trial name
- CIzQIDS (NCT02432430)
- Testing
- QI support to improve DTP/Hep B/MMR/Var/PCV/Hib/IPV coverage, Incentives to improve DTP/HepB/MMR/Var/PCV/Hib/IPV coverage
- Volunteers
- 2,186 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Influenza Vaccine
Comparison of 4 Influenza Vaccines in Seniors
Based on information from several years of looking at Influenza vaccination doctors know that: Older adults suffer the worst illness and most deaths caused by Influenza illness of all age groups.
- Trial name
- PCIRNRT09 (NCT01368796)
- Testing
- Agriflu, Fluad, Intanza
- Where
- 8 sites in Canada
- Volunteers
- 953 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Vaccine Hesitancy
Educational Intervention to Improve Vaccine Acceptance
This research project will develop an educational intervention to improve immunization acceptance by vaccine hesitant parents. This is prospective interventional case-control trial, where the investigators will provide the…
- Trial name
- NCT01385501
- Testing
- Video intervention along with educational hand out
- Where
- 2 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pneumococcal Vaccines
13vPnC Multidose Vial Safety, Tolerability and Immunogenicity Study in Healthy Infants.
This study will compare the immune responses of the infants who have been given 13vPnC in the mutidose vial formulation to the immune reponses of the infants who have been given 13vPnC in the single-dose syringe formulation.
- Trial name
- NCT01964716
- Testing
- 13-valent pneumococcal conjugate vaccine
- Where
- 2 sites in The Gambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Pfizer
HPV Vaccines
Giving Immunizations Through Vaccine Education
This study will test the effectiveness of clinician-focused health IT-based decision support, family-focused health IT-based decision support, and a combination of both efforts, in increasing HPV and other adolescent vaccine…
- Trial name
- GIVE (NCT01159093)
- Testing
- Family Decision Support, Clinician Decision Support, Family Decision Support and Clinician Decision Support
- Where
- United States
- Volunteers
- 23,675 people
- Sponsor
- Children's Hospital of Philadelphia
Completion of Three Dose Series of HPV, Improvement in Vaccine Intervals Between HPV Doses
The Efficacy of Reminders to Complete HPV Series
The human papillomavirus (HPV) vaccine is routinely recommended for both adolescent girls and boys starting at age 11, although it can be offered as young as 9 years of age.
- Trial name
- ICHAT (NCT01731496)
- Testing
- Telephone reminder, Text Message reminder
- Where
- 3 sites in United States
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Pneumonia, Pneumococcal, Pneumococcal Infections
Study Evaluating the Effiacy of a 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) in Adults
The purpose of this study is to assess the efficacy of 13-valent pneumococcal conjugate vaccine in the prevention of the first episode of vaccine-type pneumococcal community-acquired pneumonia in adults.
- Conditions
- Pneumonia, Pneumococcal, Pneumococcal Infections, 13-valent Pneumococcal Vaccine
- Trial name
- CAPITA (NCT00744263)
- Testing
- VACCINE: 13-valent pneumococcal conjugate vaccine
- Where
- 159 sites in Netherlands
- Volunteers
- 84,496 people, healthy volunteers welcome
- Sponsor
- Pfizer
Immune Globulin, Prophylaxis, Telbuvidine, Vaccine
Efficacy of Antiviral Therapy in Pregnancy in Preventing Vertical Transmission of HBV in Mothers With a High Viral Load
Mother-to-child transmission (MTCT) is the most common route of hepatitis B virus (HBV) infection. After given standard immunoprophylaxis, MTCT still occurred in some infants born to a HBsAg positive mothers with high HBV DNA…
- Trial name
- NCT02253485
- Testing
- telbivudine
- Volunteers
- 600 people
- Sponsor
- Beijing Ditan Hospital
Vaccine
Open-label Safety and Tolerability Study of CoVaccine HT™ in Healthy Volunteers
The study is being conducted to explore the safety and tolerability of CoVaccine HT in healthy male and female volunteers. In this study volunteers will receive intramuscular injections of CoVaccine HT.
- Trial name
- NCT01015703
- Testing
- CoVaccine HT
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- BTG International Inc.
Rotavirus Infections, Reaction - Vaccine Nos
Does the Fecal Microbiome Influence Rotarix Immunogenicity
This is a proposal for a nested case-control study within an ongoing rotavirus vaccine immunogenicity clinical trial Karachi, Pakistan.
- Conditions
- Rotavirus Infections, Reaction - Vaccine Nos, Intestinal Bacteria Flora Disturbance
- Trial name
- NCT02220439
- Volunteers
- 76 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
HPV Vaccine Attitudes, HPV Vaccine Intention
HPV Vaccine Acceptability Among Young Men Who Have Sex With Men
The FDA has recently approved Gardasil for the prevention of anal cancer in people aged 9-26. Men who have sex with men (MSM) have disproportionately high rates of anal cancer and could benefit greatly from vaccination.
- Trial name
- NCT01535794
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Indiana University
Pneumococcal Vaccines
Phase I Safety Trial of Streptococcus Pneumoniae Whole Cell Vaccine (SPWCV) + Alum in Healthy Adults
The purpose of this study is to determine if a Streptococcus pneumoniae Whole Cell Vaccine (SPWCV) given with alum is safe and well tolerated by healthy adults.
- Trial name
- NCT01537185
- Testing
- SPWCV+Alum 100 mcg, SPWCV+Alum 600 mcg, SPWCV+Alum 300 mcg
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- PATH Vaccine Solutions
Bacterial Infections, Staphylococcal Vaccines
An Evaluation Of Three Dose Levels Of 3-Antigen Staphylococcus Aureus Vaccine (SA3Ag) In Healthy Adults
This study is a first-in-human (Phase 1) study using three dose levels of an investigational vaccine directed against Staphylococcus aureus (SA3Ag).
- Conditions
- Bacterial Infections, Staphylococcal Vaccines, Immunotherapy, Active, Staphylococcal Skin Infections
- Trial name
- NCT01018641
- Testing
- SA3Ag vaccine, Blood draw, Colonization swab samples
- Where
- 5 sites in Australia
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Pfizer
Immunity to Influenza Vaccine
Cell Mediated Immunity in Older Adults
This study is to study the immune response to the flu vaccine in people 65 years old and older. Only adults 65 years old and older and who are getting their flu vaccine are being asked to join in this study.
- Trial name
- CMI (NCT01189123)
- Testing
- High dose influenza vaccine Sanofi-Pasteur, fluzone by sanofi pasteur
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pneumococcal Conjugate Vaccine
Study Evaluating 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Children With Sickle Cell Disease
This study is to evaluate the safety, tolerability and immunogenicity of 13-valent pneumococcal Conjugate Vaccine in children with Sickle Cell Disease who have already been vaccinated with 23-valent polysaccharide vaccine.
- Trial name
- NCT00918580
- Testing
- 13-valent Pneumoccocal Conjugate Vaccine
- Where
- 19 sites in United States, Egypt and 5 more
- Volunteers
- 158 people
- Sponsor
- Pfizer
Immunogenicity and Adverse Drug Effect of Vaccines Influenza, Chronic Kidney Disease
The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis
In recent years, several studies revealed that the current influenza vaccine strategy might be of minimal vaccine effectiveness and had a smaller effect on reducing morbidity and mortality in the end-stage renal disease…
- Trial name
- NCT02105519
- Testing
- Seasonal influenza vaccine (AdimFlu-S)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Quadrivalent HPV Vaccine, Human Papillomavirus Vaccine
Randomized Trial of Alternative HPV Vaccination Schedules in Males in a University Setting
The investigators propose a randomized, open label trial of the immunogenicity of HPV vaccine among males 18-24 years old, comparing an on-time administration of the third dose with delayed administration of the third dose.
- Trial name
- NCT01184079
- Testing
- quadrivalent human papillomavirus vaccine
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Immunization Program, School Health Services
A School Health Center Intervention to Increase Adolescent Vaccination
The study will evaluate a health services intervention to increase uptake of adolescent vaccines (HPV, Tdap, meningococcal conjugate, and influenza) among students enrolled in five school health centers by improving the consent…
- Conditions
- Immunization Program, School Health Services, HPV Vaccines
- Trial name
- NCT01595542
- Testing
- Modified Vaccine Consent Form
- Where
- United States
- Volunteers
- 3,417 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pneumococcal Vaccines
Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13®
The purposes of this study are assess the immunological response (measure the amount of antibodies, i.e. proteins that fight off germs) produced by children after they have been given the 13-valent pneumococcal vaccine (13vPnC)…
- Trial name
- NCT01392378
- Testing
- 13-valent pneumococcal conjugate vaccine, INFANRIX hexa, Paracetamol
- Where
- 14 sites in Poland
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Pfizer