Clinical trials: Urological Manifestations
Overactive Detrusor
Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity
Overactive Bladder (OAB) is a chronic condition caused by instability of the detrusor or bladder muscle, which gives rise to symptoms of urinary urgency and often urinary incontinence.
- Trial name
- NCT02009540
- Testing
- Botulinum toxin injected to bladder body, Botulinum toxin injected into trigone
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Mr HD Flood
Overactive Bladder
Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder
OnabotulinumtoxinA is an effective treatment for both idiopathic and neurogenic overactive bladder and was FDA approved for this indication in 2013.
- Trial name
- NCT04020510
- Testing
- onaBoNT-A
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Overactive Bladder
Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead
For women undergoing percutaneous nerve evaluation (PNE) for the treatment of overactive bladder the first step is the PNE interstim therapy trial. If the PNE works, patients may opt to have the interstim procedure.
- Trial name
- STIM (NCT05799313)
- Testing
- At home removal, In office removal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Proteinuria, HIV
MARCH Renal Substudy
Chronic kidney disease (CKD) is an emerging problem in patients with treated HIV. Antiretroviral therapy associated renal dysfunction has been predominantly described in terms of reduced glomerular filtration (eGFR).
- Trial name
- MARCHrenal (NCT01637259)
- Testing
- arm 1 nucleotide analogue reverse transcriptase inhibitors and boosted protease inhibitors, Arm 2 boosted protease inhibitors and maraviroc, Arm 3 nucleotide analogue reverse transcriptase inhibitors and maraviroc
- Where
- 15 sites in Argentina, Australia and 6 more
- Volunteers
- 76 people
- Sponsor
- Kirby Institute
Calcium Phosphate Kidney Stones
Treatment for Calcium Phosphate Kidney Stone Disease
The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.
- Trial name
- NCT01754779
- Testing
- Citric Acid, Potassium Citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Lower Urinary Tract Symptoms, Lower Urinary Tract Infection
PEEZY Midstream Urine Device Compared to Catheterized Urine Sample
Urine culture and microscopic urinalysis will be compared between 2 collection methods: PEEZY midstream urine collection, and urethral catheter collection.
- Trial name
- PEEZY (NCT03729336)
- Testing
- Midstream urine collection device, Catheter for urine collection
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Chronic Kidney Diseases
Propolis Effects in Patients With Chronic Kidney Disease
The aim of this study is to determine the impact of Propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.
- Trial name
- NCT02766036
- Testing
- Propolis
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Overactive Bladder (OAB), Refractory Overactive Bladder
Cefar URO - Symptomatic Treatment of Overactive Bladder
A Post-Market Prospective Clinical Investigation to collect PMCF data on the safety and performance of the Cefar URO device when using the preset program P4 (parameter setting: frequency 20Hz, pulse width 200μs) for the…
- Conditions
- Overactive Bladder (OAB), Refractory Overactive Bladder, Urinary Urgency and Frequency
- Trial name
- NCT06659536
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS) with the Cefar Uro Device
- Where
- France
- Volunteers
- 53 people
- Sponsor
- DJO UK Ltd
Stress Urinary Incontinence
Long-term Outcome of the TVT Procedure Without Preoperative Urodynamic Examination
A follow-up study of 191 patients operated on with the TVT procedure between January 1998 and May 2000 at the Department of Obstetrics and Gynecology in the Turku City Hospital.
- Trial name
- NCT01426048
- Testing
- Gynaecological examination and a supine stress test, questionnaires
- Where
- Finland
- Volunteers
- 138 people
- Sponsor
- Turku University Hospital
Chronic Kidney Disease, Unspecified
Paricalcitol on Albuminuria, Inflammation and Fibrosis on Proteinuric Chronic Renal Diseases (PALIFE Study)
The purpose of this study is to estimate the differences between albuminuria values determined as Urine Albumin-to-Creatinine Ratio (UACR)(log transformed) from baseline to last observation caused by paricalcitol between the…
- Trial name
- PALIFE (NCT01820078)
- Testing
- Experimental arm, Comparator Arm
- Where
- 25 sites in Spain
- Volunteers
- 127 people
- Sponsor
- Fundación Renal Iñigo Alvarez De Toledo
Overactive Bladder, Urinary Urge Incontinence
Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial
Patients with either overactive bladder (OAB) or urgency urinary incontinence (UUI) with be randomized (like a flip of a coin) to receive 100 units of bladder Botox® at either one injection site or ten injection sites.
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome, Urinary Incontinence, Urge
- Trial name
- NCT05308979
- Testing
- OnabotulinumtoxinA 100 UNT [Botox]
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Urology, Urinary Bladder, Overactive
Ambulatory Long Length URodynamics Evaluation
A prospective, open-label, single arm interventional trial evaluating the safety and performance of the in-clinic and extended monitoring of the lower urinary tract using the Glean Urodynamics System.
- Conditions
- Urology, Urinary Bladder, Overactive, Benign Prostatic Hyperplasia, Urodynamics
- Trial name
- ALLURE (NCT07425015)
- Testing
- Glean Urodynamics System
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Bright Uro
Bladder Irritable
Combined Dexmedetomidine and Glycopyrrolate Therapy
Catheter-related bladder discomfort after transurethral resection of bladder tumor is frequent because of indwelling urinary catheter for irrigation.
- Trial name
- NCT05013320
- Testing
- Glycopyrrolate + dexmedetomidine, Dexmedetomidine
- Sponsor
- Kangbuk Samsung Hospital
Lower Urinary Tract Symptoms, Overactive Bladder
Study to Evaluate the Clinical Efficacy and Safety of Tamsulosin Alone or in Combination With Solifenacin for the Treatment in Men With Lower Urinary Tract Symptoms Including Overactive Bladder Symptoms
The objective of this study is to evaluate the clinical efficacy and safety of tamsulosin alone or in combination with solifenacin for the treatment in men with lower urinary tract symptoms (LUTS) including overactive bladder…
- Conditions
- Lower Urinary Tract Symptoms, Overactive Bladder, Benign Prostatic Hyperplasia (BPH)
- Trial name
- NCT02715024
- Testing
- Tamsulosin, Solifenacin
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- Astellas Pharma Taiwan, Inc.
Sexual Dysfunction, Stress Incontinence
A Study to Measure the Degree and Effectiveness of the Various vSculpt Operating Modes
A pilot study to determine the degree and effectiveness of the various modes of vSculpt, an over-the-counter "OTC" medical device, on enhanced genital blood flow and improvement in quality of life in menopausal women who suffer…
- Trial name
- NCT02856490
- Testing
- vSculpt, InTone
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Joylux, Inc.
Urinary Incontinence, Stress
Tension-free Vaginal Tape (TVT) Versus Bulking Agent for the Treatment of Post Vulvectomy Urinary Incontinence
The surgical treatment of vulvar cancer is characterized by a radical approach as standard, often associated to an important rate of functional complications.
- Trial name
- NCT01148290
- Testing
- Tension free vaginal tape, Bulking agent injection
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Proteinuria, Transplant Glomerulopathy
Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients
The goal of this study is to evaluate the benefit of ACTH (Acthar) in reducing proteinuria associated with transplant glomerulopathy in non-diabetic kidney transplant recipients.
- Trial name
- NCT02057523
- Testing
- Acthar
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Illinois Chicago
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI)
Development and Validation of a Risk Prediction Model for De Novo Stress Urinary Incontinence After Pelvic Floor Reconstruction Surgery
This observational study aims to develop a predictive model for the occurrence of new-onset stress urinary incontinence (SUI) after pelvic organ prolapse (POP) repair surgery in women.
- Trial name
- NCT07601282
- Testing
- Telephone follow-up
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Urinary Incontinence, Urinary Bladder, Overactive
An Observational Study of BOTOX® for the Management of Urinary Incontinence in Patients With Idiopathic Overactive Bladder
This study will evaluate real world pattern of use of BOTOX® in actual clinical practice in patients with idiopathic overactive bladder (iOAB) with urinary incontinence whose symptoms have not been adequately managed by oral…
- Trial name
- GRACE (NCT02161159)
- Testing
- botulinum toxin Type A
- Where
- 54 sites in Germany, Spain and 2 more
- Volunteers
- 515 people
- Sponsor
- Allergan
Stress Urinary Incontinence, Urinary Incontinence
Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence
This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after…
- Conditions
- Stress Urinary Incontinence, Urinary Incontinence, Mixed Urinary Incontinence
- Trial name
- BASIS (NCT06480227)
- Testing
- Solyx Single-incision Sling, Bulkamid Transurethral Bulking Agent
- Where
- 7 sites in United States
- Volunteers
- 358 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
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