Clinical trials: Urinary Frequency More Than Once at Night
Nocturia
Study in Healthy Male Subjects to Evaluate the Effect of Itraconazole and Rifampicin on the PK of Fedovapagon
The purpose of this study is to investigate the potential for co-administration of strong inhibitors or inducers of CYP3A4 to alter the pharmacokinetics of fedovapagon.
- Trial name
- NCT02440841
- Testing
- fedovapagon, Itraconazole, rifampicin
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Vantia Ltd
Nocturia
VA106483 Dose Response Study in Elderly Males
The main purpose of the study is to evaluate the way VA106483 enters and leaves the blood and tissues over time and how the drug acts on and in the body at various dose levels compared to placebo in the same volunteer.
- Trial name
- NCT00922740
- Testing
- VA106483
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vantia Ltd
Nocturia
Bioavailability of [14C]-SK-1404 ADME & IV Microtracer Study
The primary objectives of the study are: To determine the absolute bioavailability of SK-1404 To assess the mass balance recovery after a single oral (PO) dose of carbon-14 (14C)-SK-1404 To provide plasma, urine and faecal…
- Trial name
- NCT02878096
- Testing
- [14C]-SK-1404
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Sleep Fragmentation, Poor Quality Sleep
Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production
Nocturia is prevalent in older adults and it vastly reduces quality of life. Yet its treatment remains inadequate because its causes are not well understood, especially nocturnal polyuria or increased urine production at night.
- Conditions
- Sleep Fragmentation, Poor Quality Sleep, Nocturia, Nocturnal Enuresis
- Trial name
- NCT03883724
- Testing
- Brief behavioral treatment of insomnia (BBTI), Information-only control (IC)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Edema Leg, Venous Insufficiency of Leg
Discovering the Effect of Venous Insufficiency on Nocturia (DEVINe)
Nocturia, or waking during the night to pass urine, is a multifactorial disease. An important cause of nocturia are peripheral edema due to accumulation of fluid in the lower limbs.
- Conditions
- Edema Leg, Venous Insufficiency of Leg, Nocturia, Bio-Impedance Measurements
- Trial name
- DEVINe Pilot (NCT03928197)
- Testing
- Tilt Test, Inbody S10, Tape measurements
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Nocturia, Polyuria
Food and Salt Handling in Diuresis
Understanding the impact of food/nutrients on body fluid metabolism is important for improving diagnosis and treatment of nocturia, polyuria in relation to lifestyle interventions.
- Trial name
- NCT04526340
- Testing
- Blood sample, Bio-impedance measurement (BIA), Ingestion of testing nutrient/food capsules
- Where
- Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Healthy
A Study in Healthy Volunteers to Assess the Effect of Fedovapagon on the QT/QTC Interval
The purpose of this study is to assess the electrocardiogram (ECG) effects of fedovapagon dose administration relative to placebo in healthy adult male and female subjects.
- Trial name
- NCT02537288
- Testing
- Fedovapagon, Moxifloxacin
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Vantia Ltd
Nocturia, Acupoint
Moxibustion for Nocturia
Nocturia, the interruption of sleep due to nighttime voiding, severely compromises quality of life, emotional health, and overall well-being when occurring twice or more per night.
- Conditions
- Nocturia, Acupoint, Moxibustion, Traditional Chinese Medicine
- Trial name
- NCT07598227
- Testing
- Moxibustion
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Bladder Function
Pilot Trial in Sleep Laboratory Setting to Compare the Physiology of Night Time Bladder Function in Subjects With Overactive Bladder (OAB) Versus Subjects That Have Insomnia and Healthy Normal Subjects
This is an observational, physiology pilot study of subjects with overactive bladder, insomnia and normal subjects. No study drug will be given. All subjects will complete a one week sleep diary and a 3-day bladder diary.
- Trial name
- Nocturia Plt 1 (NCT01029015)
- Testing
- cystometry, polysomnography
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Overactive Bladder, Urgency-frequency Syndrome
TEST-ON - Does iStim Reduce Urinary Urgency?
Overactive bladder (OAB) is a chronic disorder with an overall prevalence in the adult population of over 10%, but that may exceed 40% in elderly groups.
- Conditions
- Overactive Bladder, Urgency-frequency Syndrome, Urinary Frequency More Than Once at Night
- Trial name
- TEST-ON (NCT04957524)
- Testing
- iStim TENS unit and Transvaginal Probe
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
BPH, Prostate Hyperplasia
MRI Guided Transrectal Prostate Laser Ablation for Benign Prostatic Hypertrophy (BPH)
Over 100,000 BPH procedures are performed annually in the US. The purpose of this study is to evaluate the effectiveness of performing MRI guided transrectal laser ablation using a 980 nm laser (VisualaseTM by Medtronic, Inc., a…
- Conditions
- BPH, Prostate Hyperplasia, Urinary Frequency/Urgency
- Trial name
- NCT03131544
- Testing
- MRI Guided Transrectal Periuretheral Transitional Zone Ablation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Prostate Laser Center, PLLC
Idiopathic Edema Nocturia
Study of Idiopathic Edema
Idiopathic edema (IE) is an ill-defined syndrome of uncertain etiology that occurs virtually exclusively in women. It has also been referred to as cyclical edema, periodic edema, fluid retention syndrome and orthostatic edema.
- Trial name
- NCT01681927
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Benign Prostatic Hyperplasia
Urolift Pre-SBRT for Reduced Urinary Toxicity in Patients With BPH and Prostate Cancer.
Many patients may face long-term urinary side effects following stereotactic body radiation therapy (SBRT), including increased urinary frequency, dysuria, and nocturia.
- Trial name
- NCT05148156
- Testing
- Urolift
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Erectile Dysfunction, Nocturia, Short Term Insomnia, Obstructive Sleep Apnea
Effects of Nightshift Work and Sleep Disturbances on Erectile Function
We aim to observe the unwanted effects of nightshift work and short term insomnia on erectile function of men aged between 25 to 60 years.
- Trial name
- NCT04707807
- Testing
- IIEF-5
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Nocturia, Menopause
Hormonal Influences on Diuresis
The aim of this study was to observe the effect of hormonal treatment (oral or transdermal substitution therapy) on diuresis (salt and water diuresis) and lower urinary tract symptoms (LUTS) in postmenopausal women
- Conditions
- Nocturia, Menopause, LUTS, Diuresis
- Trial name
- HODI (NCT04891926)
- Testing
- ICIQ FLUTS Questionaires, Frequency Volume Chart, Renal Function Profile
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Nocturia, Pelvic Organ Prolapse
Severe Pelvic Organ Prolapse and Post-Obstructive Diuresis (SOPPO) Pilot Study
In our experience, women with severe pelvic organ prolapse (POP) frequently have bothersome nocturia. The International Continence Society (ICS) defines nocturia as "having to wake at night one or more times to void." Though some…
- Trial name
- SOPPO (NCT02060331)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loyola University
Urinary Incontinence
Evaluation Trial of Handheld Urinal for Adult Use
Usability and efficacy evaluation of a prototype handheld urinal for adult use
- Trial name
- NCT04897932
- Testing
- RS - WP06
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Binding Sciences Limited
Overactive Bladder Syndrome
Efficacy of Transcutaneous Versus Percutaneous Posterior Tibial Nerve Stimulation in the Overactive Bladder.
The main aim of this study, is compare the effectiveness of transcutaneous posterior tibial nerve stimulation versus percutaneous posterior nerve stimulation in patients with overactive bladder.
- Trial name
- NCT04483817
- Testing
- Transcutaneous tibial nerve stimulation, Percutaneous tibial nerve stimulation
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Fisiocore LC,SL
Nocturia
VA106483 Dose Response in Females
The purpose of this study is to describe the pharmacokinetics and pharmacodynamics of VA106483 in female subjects.
- Trial name
- NCT01171391
- Testing
- VA106483
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Vantia Ltd
Urinary Incontinence
A Comparison of Tolterodine and Placebo Treatments on Nocturnal Frequency and Sleep Quality in Women After Menopause.
This study is being done to compare frequency of urination during the night when women take tolterodine tablets vs. when they take placebo tablets.
- Trial name
- NCT00323635
- Testing
- tolterodine
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital