Clinical trials: Urinary Bladder Overactive, open to volunteers
Overactive Bladder (OAB), Botulinum Toxin Injection
Pretibial TENS for Pain and Anxiety During Intravesical OnabotulinumtoxinA Injection
Overactive bladder is a common condition that causes a frequent, urgent need to urinate and can significantly reduce quality of life.
- Conditions
- Overactive Bladder (OAB), Botulinum Toxin Injection, Procedural Pain Relief, Anxiety
- Trial name
- NCT07707791
- Testing
- Active Pretibial TENS
- Volunteers
- 68 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Urge Incontinence, Urgency-frequency Syndrome
Percutaneous Nerve Evaluation Trial Time
Sacral neuromodulation (SNM) was approved by the Food and Drug Administration (FDA) for the treatment of urgency incontinence (UUI) in 1998.
- Conditions
- Urge Incontinence, Urgency-frequency Syndrome, Overactive Bladder
- Trial name
- NCT06226220
- Testing
- Sacral neuromodulation
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Urinary Urge Incontinence (UUI), Urinary Frequency (UF)
Aquarius Pilot Study to Evaluate the New Axonics Trial System
Evaluation of the new Axonics External Trial System (ETS-02) in patients with overactive bladder (OAB) and/or fecal incontinence (FI).
- Conditions
- Urinary Urge Incontinence (UUI), Urinary Frequency (UF), Fecal Incontinence (FI), Overactive Bladder (OAB)
- Trial name
- NCT07335484
- Testing
- Axonics External Trial System (ETS)
- Where
- 5 sites in United States, Australia
- Volunteers
- 75 people
- Sponsor
- Axonics, Inc.
Radiation Exposure, Overactive Bladder
Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement
Fluoroscopy is performed when placing a lead during a sacral neuromodulation procedure. During lead placement, subjects will receive either conventional or experimental fluoroscopic settings.
- Conditions
- Radiation Exposure, Overactive Bladder, Urge Incontinence, Urgency-frequency Syndrome
- Trial name
- NCT04527445
- Testing
- Reduced radiation fluoroscopy, Conventional fluoroscopy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Loma Linda University
Overactive Bladder (OAB)
Comparing Treatments for Overactive Bladder in Taiwan: A Study of Outcomes
Overactive bladder (OAB) syndrome is a prevalent condition that significantly impairs patients' quality of life. Standard therapeutic strategies include oral antimuscarinics (e.g., solifenacin), beta-3 adrenergic agonists (e.g.…
- Trial name
- NCT07025642
- Testing
- Urodynamic evaluation before and after solifenacin treatment., Urodynamic evaluation before and after mirabegron treatment., Urodynamic evaluation before and after combined treatment with solifenacin and mirabegron.
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Mackay Medical College
Urinary Bladder, Overactive, Urodynamics
Evaluation the Efficacy Between Botox Injection and Combination Pharmacotherapy in Patients With Detrusor Overactivity
To investigates the effects of botulinum toxin type A bladder injection compared to combined pharmacotherapy with Mirabegron and Solifenacin.
- Conditions
- Urinary Bladder, Overactive, Urodynamics, Effect of Drug
- Trial name
- NCT05968885
- Testing
- Intradetrusor Botox® (onabotulinumtoxinA) injection, Combine Mirabegron and Solifenacin.
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Mackay Memorial Hospital
Overactive Bladder Syndrome, Urinary Incontinence
Improving Overactive Bladder Treatment Access and Adherence
Overactive bladder (OAB) and urinary incontinence (UI) are chronic debilitating and embarrassing conditions that affect 33 million Americans.
- Trial name
- NCT06094543
- Testing
- Patient Engagement Tool
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Urinary Incontinence in Children
Efficacy of Solifenacin, Mirabegron and Combination Therapy in Children With Daytime Urinary Incontinence (BeDry)
The primary objective is to evaluate if (1) combination therapy of solifenacin and mirabegron in low doses is superior to monotherapy of solifenacin in high dose and if (2) combination therapy of mirabegron and solifenacin in low…
- Trial name
- NCT06551246
- Testing
- Solifenacin, Mirabegron
- Where
- 5 sites in Denmark
- Volunteers
- 236 people
- Sponsor
- University of Aarhus
Overactive Bladder
Clinical and Urodynamic Assessment of Bladder Sensation in Multiple Sclerosis
The aim of the study is to assess the association between bladder sensations progression during bladder filling and severity of Overactive bladder (OAB) in patients with multiple sclerosis.
- Trial name
- CUBS-MS (NCT05772637)
- Testing
- Repeated cystometries with bladder sensations assessment
- Where
- France
- Volunteers
- 113 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Antibiotic Prophylaxis
Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA
This study aims to show that lack of antibiotic prophylaxis to those undergoing bladder Botox injections is not significantly inferior to administering prophylaxis.
- Trial name
- NCT05519072
- Testing
- Nitrofurantoin
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Overactive Bladder Syndrome, Overactive Bladder
BTL Emsella Chair Versus Sham for the Treatment of Overactive Bladder
The purpose of this clinical trial is to compare the Emsella Chair therapy to Sham and to determine whether electromagnetic technology is effective in the treatment of overactive bladder (OAB).
- Conditions
- Overactive Bladder Syndrome, Overactive Bladder, Urinary Frequency, Urinary Urgency
- Trial name
- EmsellaOAB (NCT04873037)
- Testing
- BTL Emsella Chair
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Corewell Health East
Bladder Hyperactivity, Sacral Neuromodulation
Evaluation of Autonomic Nervous System Changes in Response to Stimulation by Sacral Neuromodulation
Overactive bladder syndrome (OAB) is defined by urgent and frequent urges to urinate associated with frequent night-time urination and sometimes urinary incontinence.
- Trial name
- ESTIME (NCT06434831)
- Testing
- Medical device for SNM: Interstim X or Interstim micro
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Overactive Bladder
Bladder Overactivity and Post-Botulinum Toxin Telemonitoring
Prospective, randomized, controlled, single-center study to compare the feasibility of home monitoring for patients receiving intradetrusor botulinum toxin injections with that of the usual hospital-based follow-up.
- Trial name
- VESIC@HOME (NCT07379372)
- Testing
- home care
- Volunteers
- 112 people
- Sponsor
- University Hospital, Grenoble
Overactive Bladder (OAB), Urgency Urinary Incontinence
Long-Term Effectiveness and Safety of Sacral Neuromodulation With InterStim for Lower Urinary Tract Dysfunction
This observational study will evaluate the long-term effectiveness, safety, and patient satisfaction associated with sacral neuromodulation using the InterStim™ system in adults treated for lower urinary tract dysfunction at…
- Conditions
- Overactive Bladder (OAB), Urgency Urinary Incontinence, Non-obstructive Urinary Retention, Non-obstructive Acontractile Detrusor
- Trial name
- NCT07856238
- Testing
- InterStim™ Sacral Neuromodulation System II - X
- Where
- Colombia
- Volunteers
- 1,700 people
- Sponsor
- Fundación Santa Fe de Bogota
Overactive Bladder (OAB), Overactive Bladder Syndrome
Real-world Experiences and Voices Exploring the Actual Lived Burden of OAB: A Mixed-methods Multi-country PROMs Study on OAB Patients' Quality of Life
The main goal is to understand what it is truly like to live with OAB from the patient's perspective, including how it affects: daily activities, emotional wellbeing and mental health, social life and relationships, work and…
- Trial name
- REVEAL-OAB (NCT07545148)
- Volunteers
- 2,000 people
- Sponsor
- European Association of Urology Research Foundation
Urinary Bladder, Overactive, Effect of Drug
Efficacy of Combined Pharmacotherapy Versus Solifenacin With Vaginal Estrogen Cream for Women With Detrusor Overactivity
To investigates the effects of combined pharmacotherapy with solifenacin and mirabegron versus solifenacin with vaginal estrogen cream in women with detrusor overactivity.
- Trial name
- NCT06197295
- Testing
- Solifenacin with vaginal estrogen cream, Combination pharmacotherapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Mackay Memorial Hospital
Urinary Incontinence, Urinary Bladder Overactive
Does Use of a Pre-Procedure Educational Video for Urodynamic Testing Reduces Anxiety?
The objective of this randomized prospective study is to evaluate whether viewing an educational video before urodynamic testing reduces anxiety among women undergoing evaluation for pelvic floor or urinary symptoms.
- Conditions
- Urinary Incontinence, Urinary Bladder Overactive, Urinary Incontinence , Stress
- Trial name
- VIDEO-U (NCT07740629)
- Testing
- video
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Yair Daykan
Overactive Bladder
Predictive Utility and Mechanisms of Sacral Evoked Responses in Sacral Neuromodulation
Electrical stimulation of the sacral nerve can help with bladder problems and pelvic pain but researchers don't understand exactly how the stimulation helps.
- Trial name
- NCT06983470
- Testing
- SNM based on visual-motor responses (VMRs), SNM based on sacral evoked responses (SERs)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Bladder Dysfunction, Overactive Bladder
Noninvasive Ultrasound Assessment of Detrusor Dysfunction
The purpose of this study is to test a new ultrasound method called Quantitative Ultrasound Bladder Vibrometry to detect abnormal bladder function.
- Conditions
- Bladder Dysfunction, Overactive Bladder, BPH With Urinary Obstruction
- Trial name
- NUADD (NCT05652023)
- Where
- United States
- Volunteers
- 2,023 people
- Sponsor
- Mayo Clinic
Overactive Bladder, Urge Incontinence
A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)
A prospective, multicenter, single-arm study to evaluate the safety and effectiveness of the eCoin® implanted tibial nerve stimulator in subjects with urgency urinary incontinence (UUI).
- Conditions
- Overactive Bladder, Urge Incontinence, Incontinence, Urinary, Urinary Urge Incontinence
- Trial name
- RECIPE (NCT05685433)
- Testing
- eCoin Tibial Nerve Stimulation
- Where
- 22 sites in United States
- Volunteers
- 200 people
- Sponsor
- Valencia Technologies Corporation