Clinical trials: Upper Limb Surgery, open to volunteers
Recurrent Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer
BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy Progression
This is a multicenter, single-arm, phase II clinical study evaluating the efficacy and safety of neoadjuvant finotonlimab (anti-PD-1), cetuximab (anti-EGFR), and docetaxel in patients with resectable recurrent head and neck…
- Trial name
- BRIDGE (NCT07618624)
- Testing
- Finotonlimab, Cetuximab, Docetaxel
- Where
- 9 sites in China
- Volunteers
- 42 people
- Sponsor
- Sun Yat-sen University
Acute Kidney Injury, Surgery Complications
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial
This investigator-initiated, pragmatic trial evaluates whether displaying a machine learning (ML)- derived perioperative AKI risk score-alone or paired with an interruptive Best/Our Practice Advisory (BPA/OPA)-improves…
- Conditions
- Acute Kidney Injury, Surgery Complications, Anesthesia
- Trial name
- ML-AKI (NCT07604662)
- Testing
- EHR-Embedded AKI Risk Score, EHR-Embedded AKI Risk Score with Best Practice Advisory
- Where
- United States
- Volunteers
- 25,518 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Supraspinatus Tear
Treatment of the Biceps With Concomitant Supraspinatus Tears
The long head of the biceps (LHB) tendon is thought to be a common source of shoulder pain and dysfunction in patients with rotator cuff pathology.
- Trial name
- NCT05660031
- Testing
- LHB Tenotomy, LHB Tenodesis
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- La Tour Hospital
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Dry Eye Disease (DED)
Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery
To review how patients report using a hyaluronate crosslinked canalicular gel placed before cataract surgery
- Trial name
- LaReCa (NCT07155057)
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction
Prehabilitation in Breast Cancer Surgery
This prospective, randomized, assessor-blinded, parallel-group clinical trial evaluates the effectiveness of a home-based upper extremity-focused prehabilitation program in women undergoing breast cancer surgery.
- Conditions
- Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction, Lymphedema Arm, Cancer Rehabilitation
- Trial name
- NCT07425379
- Testing
- Home-Based Prehabilitation Exercise Program, Usual Care
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Head and Neck Squamous Cell Carcinoma
Neoadjuvant Toripalimab or Toripalimab in Combination With Carboplatin and Nab-paclitaxel in Untreated HNSCC (HNSCC-002)
This proposed study will evaluate the efficacy and safety of preoperative administration of Toripalimab or Toripalimab combined with nab-paclitaxel and carboplatin in Head and Neck Squamous Cell Carcinoma (HNSCC) who are about to…
- Trial name
- NCT04807140
- Testing
- Toripalimab, nab-paclitaxel, carboplatin, Toripalimab, Surgical resection
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer Invasive
A Phase II Clinical Trial of Artificial Intelligence-assisted One-stop Radiotherapy for Breast Cancer After Breast-conserving Surgery
Background: Breast cancer became the most prevalent cancer globally in 2020, and post-surgery radiotherapy is crucial for most patients. Traditional radiotherapy is complex and time-consuming, affecting patient experience.
- Trial name
- BC-AIO (NCT06686459)
- Testing
- ALL-in-one radiotherapy, IMRT
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Sun Yat-sen University
Lung Cancer, Carcinoma, Squamous Cell
Neoadjuvant Targeted Therapy in Patients With Resectable EGFR-mutated Lung Squamous Cell Carcinoma
Previous trials, such as ADURA and CTONG, have demonstrated the benefits of neoadjuvant targeted therapy in patient with EGFR mutations , which can effectively reduce the extent of tumors and improve the survival outcomes.
- Trial name
- GALAXY-02 (NCT06383728)
- Testing
- Osimertinib
- Where
- China
- Volunteers
- 51 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Solid Tumors, Adult
PANK-003 Cell Injection Combined with Standard Adjuvant Chemotherapy After Surgery in Patients with Solid Tumors
A single-center, single-arm, dose-escalation exploratory clinical trial on the safety and efficacy of PANK-003 cell injection(Peripheral blood-derived allogeneic natural killer cells )combined with standard adjuvant chemotherapy…
- Trial name
- NCT06897228
- Testing
- PANK-003 cell injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shenzhen Celconta Life Science Co., Ltd.
Nasopharyngeal Cancer Recurrent, Nasopharyngeal Cancinoma (NPC)
Perioperative Chemotherapy and Immunotherapy for Locally Recurrent Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is an endemic malignancy in Southern China and southeast Asia. Despite intensive radical therapy, between 15% and 30% of NPC patients develop relapse.
- Trial name
- NCT07129772
- Testing
- Gemcitabine (GEM), Cisplatin, PEMBROLIZUMAB (alone or when added to a regimen above)
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- The University of Hong Kong
Non-small Cell Lung Cancer Stage III
Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node or Other High Risk Features
The goal of this clinical trial is to learn about neoadjuvant cemiplimab with histology-specific chemotherapy followed by resection and adjuvant cemiplimab in stage 3 non-small cell lung cancer (NSCLC) with select N3 lymph node…
- Trial name
- NEO-SURG (NCT06449313)
- Testing
- Cemiplimab-Rwlc
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Georgetown University
Melanoma
PROSECCO: A Phase 2, Single Arm, Neoadjuvant Study Evaluating Combination Cemiplimab, Fianlimab, And Ipilimumab In Patients With Surgically Resectable Melanoma
This is a phase II study testing the safety and preliminary efficacy of triplet ICB in treatment naïve patients with clinical stage III or oligometastatic stage IV melanoma with resectable disease.
- Trial name
- NCT07511036
- Testing
- Cemiplimab, Lpilimumab, Fianlimab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia
Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture
The goal of this clinical trial is to learn whether suzetrigine (Journavx®), when added to standard multimodal pain management, can reduce opioid use while providing adequate pain control in adults undergoing surgery for an acute…
- Trial name
- STRIDE-HIP (NCT07905404)
- Testing
- Suzetrigine (Journavx)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Beth Israel Deaconess Medical Center
Laparotomy
Abdominal Wall Closure After Laparotomy in Oncologic Surgery
The REBUILD Study is a first-in-human evaluation of the safety and performance of REBUILD Bioabsorbable.
- Trial name
- REBUILD (NCT05041530)
- Testing
- REBUILD Bioabsorbable
- Where
- 2 sites in Colombia
- Volunteers
- 30 people
- Sponsor
- AbSolutions Med Inc.
Lung Non-Small Cell Carcinoma, Stage IB Lung Cancer AJCC v8
Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer
This phase II trial tests how well a fixed dose combination (FDC) of cemiplimab and fianlimab before surgery (neoadjuvant) works in treating patients with stage IB-IIIB non-small cell lung cancer (NSCLC).
- Conditions
- Lung Non-Small Cell Carcinoma, Stage IB Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
- Trial name
- N-PLANC (NCT06918132)
- Testing
- Biospecimen Collection, Cemiplimab, Fianlimab
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Distal Radius Fractures
Impact of Early ADL Education on Outcomes Post DRF ORIF
This study is a randomized controlled trial (RCT). This RCT which will study the effect of performing daily activities early after a distal radius fracture being treated with surgical intervention of open reduction and internal…
- Trial name
- NCT06251206
- Testing
- ADL/Postoperative Instruction, Postoperative Instruction
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- George Washington University
Benign Prostatic Hyperplasia
Transperineal Irreversible Electroporation for Benign Prostatic Hyperplasia
This clinical trial focuses on men with benign prostatic hyperplasia (BPH), a condition in which an enlarged prostate causes urinary problems.
- Trial name
- NCT06867315
- Testing
- Composite steep-pulse therapeutic device (CNP-III)
- Where
- 10 sites in China
- Volunteers
- 99 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Tibial Fracture
Assessment of the Verus Frame in Tibial Intramedullary Nailing
This prospective, single-arm Post-Market Clinical Follow-Up (PMCF) study, utilizing a registry-based control group, will assess the Verus frame's effectiveness in achieving precise tibial rotation and alignment during…
- Trial name
- NCT07362121
- Testing
- Verus frame to stabilize tibia
- Where
- Finland
- Volunteers
- 25 people
- Sponsor
- Hemitec Finland Oy
Muscle Spasticity, Spinal Cord Injury
Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study
Spasticity is a common complication following central nervous system injuries. Left untreated, spasticity can lead to various complications, hindering activities of daily living and diminishing independence.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Traumatic Brain Injuries
- Trial name
- NCT06733025
- Testing
- Tendon lengthening surgery, BoNT Injections
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region