Clinical trials: Upper Limb Function
Hand Function, Stroke
TheraBracelet Phase I
This project aims to test a new technology that may improve hand function impaired from a stroke, thereby improving independence and quality of life.
- Conditions
- Hand Function, Stroke, Upper Extremity, Hemiparesis
- Trial name
- NCT03318341
- Testing
- Real Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- TheraBracelet, Inc.
Partial Nephrectomy, Kidney Cancer
Use of Human Dehydrated Amnion/Chorion (DHACM) Allograft in Partial Nephrectomy
After partial nephrectomy, kidney function decreases by about 10% overall and by about 20% in the operated kidney. This is primarily due to the loss of healthy parenchymal volume during resection of the tumor.
- Conditions
- Partial Nephrectomy, Kidney Cancer, Renal Function Aggravated
- Trial name
- NCT03323021
- Testing
- Dehydrated human amnion/chorion membrane, Standard of Care
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- MiMedx Group, Inc.
Parkinson's Disease
Randomized Evaluation of the 24-Hour Coverage: Efficacy of Rotigotine
The objective of this trial is to assess the effects of transdermal rotigotine on the control of early morning motor function and sleep disorders compared to placebo in subjects with idiopathic Parkinsons´s disease.
- Trial name
- RECOVER (NCT00474058)
- Testing
- Rotigotine
- Where
- 47 sites in United States, Australia and 10 more
- Volunteers
- 287 people
- Sponsor
- UCB Pharma
Heart Transplantation
A Study of Daclizumab (Zenapax) in Combination With Mycophenolate Mofetil (CellCept) and Sirolimus in Prevention of Acute Rejection in Heart Transplant Participants
This study will evaluate the efficacy and safety of intravenous daclizumab in combination with oral mycophenolate mofetil and oral sirolimus in participants receiving a heart transplant, and at risk of impaired kidney function.
- Trial name
- NCT02554955
- Testing
- Daclizumab, Mycophenolate mofetil, Silrolimus
- Where
- 14 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Healthy
The ILLUMINATE Study
The research study will be conducted to obtain baseline, or "normative" information to compare an air charged HRAM catheter to traditional solid catheter measures using the IAPWG standardized testing protocol and London…
- Trial name
- ILLUMINATE (NCT06805240)
- Testing
- Air Charged Catheter ARM Procedure, Solid State Catheter ARM Procedure
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Laborie Medical Technologies Inc.
Functional Mitral Regurgitation
Safety and Effectiveness Study of SQ-Kyrin TMVr System for Functional Mitral Regurgitation
To verify the safety and effectiveness of transcatheter mitral valve clip delivery system and steerable guide catheter produced by Shanghai Shenqi Medical Technology Co., Ltd.
- Trial name
- NCT05988450
- Testing
- SQ-Kyrin Transcatheter Mitral Valve Repair System
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Shanghai Shenqi Medical Technology Co., Ltd
Functional Tricuspid Regurgitation
Evaluation of Safety and Efficacy of Pivot Balloon to Monitoring Acute RV Failure and Reduction of FTR
Pivot Balloon to monitoring acute RV failure and reduction of Functional Tricuspid Regurgitation
- Trial name
- NCT05648838
- Testing
- Pivot Balloon Catheter
- Where
- 10 sites in South Korea
- Volunteers
- 7 people
- Sponsor
- Tau-MEDICAL Co., Ltd.
Asthma
Efficacy and Safety of CHF 1535 200/6µg in Not Adequately Controlled Asthmatic Patients
Primary objective To show the superiority of CHF 1535 (BDP/FF) pMDI (800/24 μg per day) over BDP HFA pMDI (800 μg per day) in terms of change from baseline to the entire treatment period in average pre-dose morning peak…
- Trial name
- FORCE (NCT01577082)
- Testing
- CHF1535 200/6 µg pMDI, BDP HFA 100 µg pMDI
- Where
- 66 sites in Bulgaria, Czechia and 7 more
- Volunteers
- 542 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Cirrhosis, Portal Hypertension
A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis
Endothelin is a human hormone which has been associated with increased portal pressure in patients with liver cirrhosis (also called portal hypertension). Ambrisentan blocks the effects of endothelin.
- Conditions
- Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT03827200
- Testing
- Ambrisentan
- Where
- 6 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Noorik Biopharmaceuticals AG
Irritable Bowel Syndrome-IBS
Evaluate the Safety of Linaclotide in IBS-C Patients in China
This is a Multi-center, single arm, observational study to evaluate the safety of linaclotide in IBS-C patients in China. Enrolls approximately 3,000 Chinese patients from 30 participating sites around China and followed up for…
- Trial name
- Liberty (NCT04462900)
- Where
- 29 sites in China
- Volunteers
- 3,028 people
- Sponsor
- AstraZeneca
Stroke
The Effectiveness of Occupation-based Bilateral Arm Training on Motor Functions and Activity Participation Among Stroke Survivors During Inpatient Rehabilitation.
People with stroke often experience limitations in motor functions and activity participation. Occupation-based bilateral upper limb training (OBBT) using occupations as meaningful daily activities, and as part of the therapy.
- Trial name
- NCT07164612
- Testing
- Occupation-Based Bilateral Upper Limb Training (OBBT), Conventional therapy group
- Where
- Qatar
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Stress, Dyspepsia
Clinical Study of De-Stress & Happy Gut Powder for Stress and Indigestion in Adults.
The current study focuses on clinical validation of efficacy of nutraceutical product in relieving stress and functional dyspepsia symptoms in adults for gut health.
- Conditions
- Stress, Dyspepsia, Indigestion
- Trial name
- NCT06568965
- Testing
- De-stress & happy gut powder-U001, De-Stress & Happy Gut powder-I001
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Herbolab India Pvt. Ltd.
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Functional Constipation (FC)
Efficacy of Notrande Shuhuajun Probiotic Supplement on Lmproving Constipation in Preschool Children
The goal of this interventional study is to evaluate the effectiveness of Notrande Shuhuajun Probiotic Supplement intake on the improvement of functional constipation in preschool children (3-6 years old).
- Trial name
- NCT07002489
- Testing
- Nuotelande Shuhuajun Study Product
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Shandong Sibote Biotechnology Co., Ltd.
Pulmonary Arterial Hypertension
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
The primary objective of this study is to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in…
- Trial name
- ARTISAN (NCT05203510)
- Testing
- Parenteral Treprostinil, Oral Treprostinil
- Where
- 28 sites in United States
- Volunteers
- 52 people
- Sponsor
- United Therapeutics
Atrial Functional Mitral Regurgitation, Heart Failure
Atrial Functional Mitral Regurgitation Response In Mitral Loop Cerclage Annuloplasty (AFRICA Study)
To evaluate second stage safety and feasibility of Mitral Loop Cerclage(MLC) Annuloplasty with CSTV for repair of functional mitral regurgitation.
- Trial name
- AFRICA (NCT03453853)
- Testing
- Mitral Loop Cerclage Annuloplasty
- Where
- 7 sites in South Korea
- Volunteers
- 1 people
- Sponsor
- Tau-MEDICAL Co., Ltd.
Moderate Arm Paresis, Ischemic Stroke
Comparison of Four-Channel Functional Electrical Stimulation vs. One-Channel Electrical Stimulation on Moderate Arm/Hand Paresis in Subacute Stroke Patients
This study will compare two treatments that may help participants recover after having suffered from stroke. Persons who experience weakness or paralysis of their arms/hands will be randomly placed in one of two groups.
- Trial name
- MKES2 (NCT07098572)
- Testing
- Cyclic single channel neuromuscular stimulation, Electromyogram-triggered 4 channel neuromuscular stimulation
- Where
- 3 sites in Austria
- Volunteers
- 44 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Joint Diseases, Arthritis
A Study to Compare the Frequency of Constipation Symptoms With Tapentadol Immediate Release (IR) Treatment Versus Oxycodone IR Treatment in Patients With End-stage Joint Disease
The purpose of this study is to compare bowel function/constipation that occurs during tapentadol treatment with that occuring during oxycodone treatment, as measured by the frequency of spontaneous bowel movements per week.
- Conditions
- Joint Diseases, Arthritis, Osteoarthritis
- Trial name
- NCT00784277
- Testing
- oxycodone CR, oxycodone IR, Tapentadol ER (CG5503)
- Volunteers
- 597 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Stroke, Hemiparesis
Safety and Effectiveness of Cortical Stimulation in the Treatment of Stroke Patients With Upper Extremity Hemiparesis
The purpose of this study is to assess the safety and effectiveness of cortical stimulation delivered concurrent with rehabilitation activities to enhance motor recovery in patients suffering from hemiparesis affecting the upper…
- Trial name
- EVEREST (NCT00170716)
- Testing
- Cortical Stimulation and rehabilitation, Rehabilitation
- Where
- 21 sites in United States
- Volunteers
- 174 people
- Sponsor
- Northstar Neuroscience
Prosthesis, Amputation
Functional Outcomes of Voice Recognition Prosthesis
The purpose of this study is to evaluate the use of a voice activated prosthesis interface controller for functional outcomes as compared to standard prosthesis control.
- Conditions
- Prosthesis, Amputation, Prosthesis User
- Trial name
- NCT04595071
- Testing
- Voice Activated Prosthetic Interface (VAPI) Controller
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.