Clinical trials: Upper Limb Amputation
Amputation
A Unique Body-Powered Terminal Device With Enhanced Grasping Capabilities for Individuals With Upper Limb Loss
We have developed a novel terminal device for a prosthetic arm that eliminates the functional tradeoffs seen in body-powered voluntary open devices.
- Trial name
- NCT07254247
- Testing
- Novel Prosthetic Hook, Control Hook (Light Spring), Control Hook (Heavy Spring)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Little Room Innovations, LLC
Upper Limb Amputation
Functional Performance of Voluntary Opening and Closing Body Powered Prostheses
This study will compare the functional performance of voluntary opening (VO) and voluntary closing (VC) body powered prostheses.
- Trial name
- NCT02136238
- Testing
- Hosmer 5XA voluntary opening hook, TRS Grip 3 voluntary closing hook
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Amputation, Traumatic
Human Upper Extremity (Hand and Forearm) Allotransplantation
Overall Goal To establish hand transplantation as a safe and effective reconstructive strategy for the treatment of upper extremity amputations.
- Trial name
- NCT00722280
- Testing
- Hand Transplantation
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Amputation
Enhanced Auto-Diagnostic Adaptive Precision Trainer for Myoelectric Prosthetic Users
The eADAPT training consists of a variety of mobile games played on a mobile app (phone or tablet). A band is worn on the residual limb. Participants use muscle activation to send signals to execute certain movements in the game.
- Trial name
- eADAPT (NCT04238533)
- Testing
- eADAPT training, Conventional training
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Amputation, Prosthesis User
Myoelectric Game Training and Outcomes
The purpose of this study is to evaluate the effects of myo-electric training tools on prosthesis functional outcomes.
- Conditions
- Amputation, Prosthesis User, Prosthesis
- Trial name
- NCT04354493
- Testing
- Myo-electric Gaming Interface
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Traumatic Amputation of Upper Limb, Level Unspecified
Development of a Simulation Tool for Upper Extremity Prostheses
Amputees often choose not to wear prostheses due to marginal performance or may settle for a prosthesis that offers only cosmetic improvement, but lacks function.
- Trial name
- NCT01622530
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Prosthesis User, Amputation
Prosthetic Limb Movement Feedback for Upper and Lower Extremity Amputees
To assess the functional characteristics and utility of upper and lower limb prosthetic devices (advanced bionic and current clinical standard-of-care) that incorporate physiologically relevant touch and/or movement feedback.
- Trial name
- NCT03135847
- Testing
- Tactor
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Neuroma Amputation
Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees
Background: The formation of neuromas, a fusiform swelling of a nerve or nerve ending, is a well documented response to limb amputation.
- Trial name
- NCT00686764
- Testing
- Observational
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Amputation, Amputation; Traumatic, Hand
Dexterous Partial Hand Prosthesis Outcomes
Liberating Technologies, Inc. (LTI) has developed a dexterous prosthetic fingertip that will be fit onto an i-Digits™ partial hand prosthesis and allow for an additional fine grasp.
- Conditions
- Amputation, Amputation; Traumatic, Hand, Limb; Absence, Congenital, Upper, Prosthesis User
- Trial name
- NCT05038566
- Testing
- Pointdexter
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Amputation, Traumatic
Studying Electromyographic Activity in Patients With Upper Limb Amputations
The primary purpose of this study is to determine the extent to which the Regenerative Peripheral Nerve Interface ( i.e. reinnervation of partial muscle grafts by residual peripheral nerves) enables both the generation of…
- Trial name
- NCT02956603
- Testing
- Fine wire EMG electrodes
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Upper Limb Amputees
The Effect of Amputation on Spatial Visual Representation in Peripersonal Space
In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space.
- Trial name
- NCT00458757
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Upper Limb Amputation, Healthy Subjects
Microneurography and Intraneural Microstimulation for Upper Limb Sensory Investigation in Healthy and Amputee Subjects
The goal of this experimental study is to investigate the somatosensory system through intraneural recording and stimulation of the median nerve in healthy volunteers and participants with upper-limb amputation.
- Trial name
- MICROAMP (NCT07691957)
- Testing
- Microneurography, Intraneural Microstimulation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Amputation, Surgical
Improving Prosthetic Arms for Amputee: A Better Fit and More Functionality
This research and development will improve upon and investigate the potential validity of an innovative new transradial socket and harness design (the KSH system) that offers an alternative to standard hard sockets and rubber…
- Trial name
- KSH (NCT05990062)
- Testing
- K-Socket-Harness
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amputation, Congenital, Upper Limb; Amelia
CNS Changes Following Upper Limb Loss
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following congenital upper limb loss.
- Trial name
- NCT06043518
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lower Limb Amputation Above Knee (Injury)
Decoding Motion Planning Using Cortical Potentials
The team will investigate the user's intention to move by using cortical activity during a sit to stand movement performance in people with a transfemoral amputation and able-bodied individuals.
- Trial name
- NCT04325516
- Testing
- Daily activities
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Phantom Limb Pain
Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation
The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using…
- Trial name
- NCT06813937
- Testing
- Procedure: Peripheral Magnetic Stimulation (PMS), Electroencephalography (EEG)
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Below Elbow Amputation
Enhancing Upper Limb Prostheses With Radio Frequency Identification
The purpose of this study is to determine if Radio Frequency Identification (RFID) can lead to greater prosthesis function and control.
- Trial name
- RFIDIBT (NCT01967004)
- Testing
- Morph
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Infinite Biomedical Technologies
Amputation; Traumatic, Arm, Upper
Teleoperation Experimental Comparison With Able-bodied Subjects
To compare the use of the semi-autonomous control algorithm (condition 1) with the standard of care myoelectric system used with the TASKA prosthetic hand (condition 2).
- Trial name
- NCT05048394
- Testing
- Semi-autonomous myoelectric control algorithm, Standard-of-care myoelectric control algorithm
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Point Designs
Amputation, Amputation; Traumatic, Leg, Lower
Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees
The goal of this proposed project is to gather community-based data from the K4-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to…
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User
- Trial name
- NCT05267639
- Testing
- Power Knee
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Amputation
Investigation of Embodiment for Upper Limb Amputees
Today, prosthetic hands are numb. They provide no tactile or proprioceptive sensory information back to the user. The lack of sensory feedback has been shown to reduce the utility of a prosthesis by half.
- Trial name
- NISRL (NCT04578327)
- Testing
- Prosthetic hand, Peripheral Nerve Interface
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development