Clinical trials: Upper Limb
Arthritis Knee
Quantitative Assessment of Walking (Squawk) With the Canary canturioTM te (CTE) Tibial Extension
The objective of this prospective study is to demonstrate accuracy of a limp detection model using a healthcare provider assessment as the non-reference standard.
- Trial name
- NCT05693818
- Testing
- Clinical Limping Evalution
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Canary Medical
Hepatocellular Carcinoma, Adult
PIN in Combination With Anti-PD1 in Previously Treated Primary Hepatocellular Carcinoma
In this single-center,open-label, phase I study, the safety and efficacy of PIN in combination with programmed cell death protein antibody (anti-PD1) therapeutic regimen will be evaluated in patients with refractory primary…
- Trial name
- NCT07018518
- Testing
- PIN +anti-PD1
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Chinese PLA General Hospital
Breast Cancer (Early Breast Cancer)
ADC Based Therapy Accroding to HER2 Heterogeneous
This study adopts a single-center, open-label, single-arm interventional design. It will enroll 88 patients with histologically confirmed HER2-positive early breast cancer who are suitable for surgery and neoadjuvant therapy, and…
- Trial name
- HER2level (NCT07844018)
- Testing
- HER2 target therapy
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Peking University People's Hospital
Diabetes Mellitus, Type 2
The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone)
The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in patients with type 2 diabetes mellitus who are receving treatment with metformin and pioglitazone and…
- Trial name
- NCT01106690
- Testing
- Canagliflozin, Sitagliptin, Metformin
- Where
- 83 sites in United States, Canada and 9 more
- Volunteers
- 344 people
- Sponsor
- Janssen Research & Development, LLC
Stroke
Effect of Transcranial Magnetic Stimulation on Recovery of Upper Limb Among Stroke Survivors
Approximately two thirds of stroke survivors have profoundly impaired function of the upper limb. Currently the main stay of the treatment for upper limb motor function is rehabilitation therapy focusing on repetitive and…
- Trial name
- NCT01938690
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Lymphoma. Non-Hodgkin
Study of Nivolumab in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) That Have Either Failed or Are Not Eligible for Autologous Stem Cell Transplant (CheckMate 139)
The purpose of this study is to determine whether Nivolumab is effective in the treatment of DLBCL in patients that have failed or are ineligible for ASCT
- Trial name
- NCT02038933
- Testing
- Nivolumab
- Where
- 46 sites in United States, Australia and 10 more
- Volunteers
- 121 people
- Sponsor
- Bristol-Myers Squibb
Germ Cell Neoplasms, Testicular Neoplasms
Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors
This is an open label, multi-institutional, single arm phase II trial of pembrolizumab in patients with incurable platinum refractory germ cell tumors. No randomization or blinding is involved.
- Conditions
- Germ Cell Neoplasms, Testicular Neoplasms, Non Seminomatous Germ Cell Tumors, Mediastinal Neoplasms
- Trial name
- NCT02499952
- Testing
- Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Nasser Hanna, M.D.
Pressure Injury, Skin Lesions
Paraffin Oil for Preventing Tourniquet-Related Skin Lesions in Upper Extremity Surgery
This randomized controlled trial aims to evaluate the effectiveness of topical paraffin oil application in preventing tourniquet-related skin lesions in patients undergoing upper extremity surgery.
- Conditions
- Pressure Injury, Skin Lesions, Skin Injury
- Trial name
- PARA-TOUR (NCT07523958)
- Testing
- Paraffin Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Medipol University Hospital
Elbow Injury
MDR ExploR Radial Head System PMCF
The objective of this retrospective and prospective consecutive series PMCF study is to collect long-term data confirming safety, performance and clinical benefits of the ExploR Radial Head System (implants and instrumentation)…
- Trial name
- NCT05583448
- Testing
- ExploR Radial Head
- Where
- 2 sites in United States, Norway
- Volunteers
- 93 people
- Sponsor
- Zimmer Biomet
Small Cell Lung Carcinoma
First-line Chemotherapy Followed by Toripalimab Combined With Anlotinib for Maintenance in ES-SCLC
Our aim in this study was to evaluate the efficacy and safety of etoposide combined with cisplatin or carboplatin (EC/EP) chemotherapy regimens followed by toripalimab combined with anlotinib for maintenance in extensive small…
- Trial name
- NCT04363255
- Testing
- Etoposide Injection, Carboplatin Injection, Cisplatin injection
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Taizhou Hospital
Prostate Cancer, Castration-resistant Prostate Cancer
A Biomarker Study of Standard-of-care Radium-223 Chloride for Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to look for markers of how Ra-223 improves the lives of men with prostate cancer. This study makes use of Ra-223 in the standard FDA-approved way, but adds non-standard testing in an attempt to gain…
- Conditions
- Prostate Cancer, Castration-resistant Prostate Cancer, Castration-resistant Prostate Cancer Metastatic to Bone
- Trial name
- NCT02346526
- Testing
- Blood Tests, CT scan, FACBC PET/MRI in a subset of participants
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2
A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Saudi Arabia, as Part of Local Clinical Practice
The purpose of the study is to collect information on how Rybelsus® works in people with type 2 diabetes and to see if Rybelsus® can lower their blood sugar levels.
- Trial name
- PIONEER REAL (NCT05230589)
- Testing
- Oral semaglutide
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 194 people
- Sponsor
- Novo Nordisk A/S
HER2-positive Breast Cancer
A Trial of Eribulin in Combination With HP Neoadjuvant Therapy in Patients With for HER2-Positive BC
To evaluate the pathology complete response rate (pathology Complete Response, pCR) of eribulin combined with trastuzumab + pertuzumab in neoadjuvant therapy for HER-2 positive early or locally advanced breast cancer.
- Trial name
- NCT05945368
- Testing
- Eribulin mesylate injection、Pertuzumab、Trastuzumab
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Shoulder Impingement, Frozen Shoulder
Relationship of Patient-Specific Functional Scale With Shoulder Functions: A Prospective Study
The aim of the study is to examine the relationship between the Patient- Specific Functional Scale (PSFS) and shoulder functions in the physiotherapy and rehabilitation program applied to patients with shoulder problems.
- Conditions
- Shoulder Impingement, Frozen Shoulder, Humeral Fractures, Rotator Cuff Tears
- Trial name
- NCT04538118
- Testing
- Shoulder disability, Shoulder Range of Motion, Pain Intensity
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Ankara Yildirim Beyazıt University
Epicondylitis, Lateral
Prevention of Lateral Epicondylalgia in Handgun Olympic Shooting Athletes
Lateral epicondylalgia is one of the most common pathologies suffered by Olympic gun shooting athletes. In Spain, there is hardly any research carried out in this sport, so there are no injury prevention protocols available.
- Trial name
- NCT06494332
- Testing
- Exercise and stretching programe
- Where
- Spain
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Hemiplegic Cerebral Palsy
Effect of Extracorporeal Shock Wave and Peripheral Magnetic Stimulation on Spastic CP Children
Hypotheses: There will be an effect of radial extracorporeal shock wave therapy and peripheral magnetic stimulation on the following parameters, in children with spastic hemiplegia: Wrist flexors spasticity.
- Trial name
- NCT05607134
- Testing
- selected physical and occupational therapy program, Radial Extracorporeal Shock Wave, Peripheral magnetic stimulation
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Hypoparathyroidism
A Study to Test the Effects and Safety of Palopegteriparatide in Adolescents With Long-term Hypoparathyroidism
This trial will enroll adolescents between ages of ≥12 and <18 years with clinically diagnosed hypoparathyroidism . The purpose of the study is to see how well treatment with once-daily palopegteriparatide works and how safe it…
- Trial name
- NCT07706764
- Testing
- Palopegteriparatide
- Where
- 3 sites in France, Poland
- Volunteers
- 12 people
- Sponsor
- Ascendis Pharma A/S
Chronic Obstructive Pulmonary Disease
Efficacy and Safety Study of Beclometasone/Formoterol Single Inhaler in Patients With COPD
To evaluate the 1-year efficacy and safety of the fixed combination beclometasone/formoterol pMDI in a twice daily regimen in patients with stable severe COPD.
- Trial name
- NCT00476099
- Testing
- Beclomethasone 100 µg plus formoterol 6 µg (CHF1535) pMDI, Budesonide 200 µg plus formoterol 6 µg DPI, Formoterol 12 µg DPI
- Where
- France
- Volunteers
- 828 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Recurrent Glioblastoma
HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma
This phase II trial studies how well HIF-2 alpha inhibitor PT2385 works in treating patients with recurrent glioblastoma. HIF-2 alpha inhibitor PT2385 may stop the growth of tumor cells by blocking some of the enzymes needed for…
- Trial name
- PT2385 (NCT03216499)
- Testing
- HIF-2alpha Inhibitor PT2385, Pharmacological Study, Laboratory Biomarker Analysis
- Where
- 10 sites in United States
- Volunteers
- 24 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Shoulder Proprioception, Open Capsular Shift
Shoulder Proprioception Following Open and Arthroscopic Instability Repair
Shoulder dislocations are common and may result in functionally disabling instability. Disruption of the shoulder capsuloligamentous complex during shoulder dislocation is related to poor proprioceptive and stabilizing…
- Conditions
- Shoulder Proprioception, Open Capsular Shift, Arthroscopic Bankart Repair, Unrestricted Arm Movement
- Trial name
- NCT00889109
- Testing
- Three dimensional unrestricted arm movements
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center