Clinical trials: Upper Gastrointestinal Symptoms
Upper Gastrointestinal Bleeding
Single-use Versus Reusable Gastroscopes in Patients With Upper Gastrointestinal Bleeding.
Controlled-randomized trial evaluating single-use versus reusable gastroscopes in patients with upper gastrointestinal bleeding.
- Trial name
- OneScopeII (NCT06192355)
- Testing
- Endoscopic hemostasis using a Esophagogastroduodenoscopy
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Augsburg
Gastroparesis
The Use Of Domperidone For The Relief Of Refractory Upper Gastrointestinal GI Symptoms
To prescribe oral domperidone for patients with upper GI symptoms who have failed or suffered adverse effects from standard medical therapy.
- Trial name
- NCT03810287
- Testing
- Domperidone
- Where
- United States
- Sponsor
- Yale University
Peptic Ulcer, Gastric Cancer
WEI NASAL JET for The Sedation of Outpatient Upper Gastrointestinal Endoscopy
Low pulse oximetry is the most common adverse events during sedation for upper gastrointestinal endoscopy. The main reason is the glossoptosis after sedation.
- Conditions
- Peptic Ulcer, Gastric Cancer, Esophagus Cancer, Oesophagitis
- Trial name
- NCT02436018
- Testing
- WEI NASAL JET, Nasopharyngeal airway without jet ventilator
- Where
- 3 sites in China
- Volunteers
- 1,800 people
- Sponsor
- RenJi Hospital
Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage
TEAS for Variceal Bleeding Endoscopy in Cirrhosis
This randomized controlled trial evaluates whether transcutaneous electrical acupoint stimulation (TEAS) improves procedural success and patient tolerance in cirrhotic patients undergoing urgent unsedated endoscopy for suspected…
- Conditions
- Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage, Variceal Bleeding, Cirrhosis
- Trial name
- TEAS-VBE-C (NCT07106658)
- Testing
- TEAS + Urgent Endoscopy, Urgent Endoscopy Only
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing 302 Hospital
Esophageal Stricture, Eosinophilic Esophagitis
EndoFLIP Use in Upper GI Tract Stenosis
The purpose of this study is to investigate the use of a functional luminal imaging probe to characterize benign esophageal luminal strictures before and after dilation and identify predictors of response to therapy.
- Conditions
- Esophageal Stricture, Eosinophilic Esophagitis, Zenkers Diverticulum, Schatzki Ring
- Trial name
- EndoFLIP (NCT02354716)
- Testing
- EndoFLIP
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Cough, Cough Variant Asthma
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
The aim of the study is to assess the prevalence of bronchial hyperresponsiveness (BHR) in non-smoking adults with chronic cough and the prevalence of BHR in patients with upper airway cough syndrome (UACS) and gastroesophageal…
- Conditions
- Cough, Cough Variant Asthma, Upper-Airway Cough Syndrome, GERD
- Trial name
- NCT03363698
- Testing
- Cough variant asthma treatment
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Esophageal Motility Disorders
Prevalence of IEM Among Upper GIT Symptoms
detect the prevalence of IEM among upper git symptom . clarify the role of HRM in diagnosis of refractory upper GIT symptoms.
- Trial name
- NCT05913011
- Volunteers
- 50 people
- Sponsor
- Assiut University
Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB), Gastrointestinal Hemorrhage (Clinically Important, Upper), Drug-Related Side Effects and Adverse Reactions
- Trial name
- FENOX (NCT07497893)
- Testing
- Fexuprazan, NOAC therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Peptic Ulcers, Upper Gastrointestinal Bleeding
High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
- Trial name
- NCT00374101
- Testing
- omeprazole, pantoprazole
- Where
- 10 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Acute Upper Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding
Trimebutine Maleate for Enhancing Gastric Visualization in Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding is a medical emergency that requires an urgent upper endoscopy to locate and treat the source of the bleeding.
- Conditions
- Acute Upper Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding, Gastrointestinal Hemorrhage
- Trial name
- NCT07749300
- Testing
- Trimebutine Maleate
- Volunteers
- 100 people
- Sponsor
- Assiut University
Frailty, Surgery--Complications
Protocol for Patients Above 75 Years Undergoing Emergency Laparotomy
In the ProPEL study the effect of a protocol designed for elderly patients about to undergo emergency abdominal surgery will be investigated. The protocol addresses issues of both frailty and ceiling-of -care decisions.
- Conditions
- Frailty, Surgery--Complications, Outcome, Fatal, Frail Elderly Syndrome
- Trial name
- (ProPEL) (NCT04293653)
- Testing
- Protocol for patients above 75 undergoing emergency laparotomy or laparoscopy
- Where
- Norway
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
GERD
Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study is a randomised, double-blind, parallel-group and placebo controlled study comparing the efficacy of esomeprazole 40 mg orally qd vs. placebo and esomeprazole 20 mg orally qd vs.
- Trial name
- NCT00241540
- Testing
- Esomeprazole
- Where
- 119 sites in United States, Belgium and 4 more
- Volunteers
- 808 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Prevalence of Gastroesophageal Reflux Disease in Primary Care Patients With Upper Gastrointestinal Symptoms
The purpose of this study is to provide data on the gastroesophageal reflux disease (GERD) prevalence as percentage of patients with upper gastrointestinal (GI) symptoms that are identified with GERD using the Gerd-Q…
- Trial name
- NCT01020890
- Where
- 12 sites in Bulgaria
- Volunteers
- 2,210 people
- Sponsor
- AstraZeneca
Gastrointestinal Bleeding
Prospective Assessment of the Rockall Risk ScoringSystem in Patients With Upper Gastrointestinal Hemorrhage
This study aimed to Assess the validity of the Rockall score for the prediction of rebleeding and death in patients with upper gastrointestinal bleeding.
- Trial name
- NCT02405286
- Testing
- Upper gastrointestinal endoscopy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2, Obesity
Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy
To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Gastroparesis
- Trial name
- NCT06533527
- Testing
- GLP-1 medication
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Dyspepsia, Malabsorption Syndrome
Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
There is some controversy in the medical literature regarding the effectiveness of topical lidocaine in children as an adjuvant drug to upper gastrointestinal endoscopy.
- Conditions
- Dyspepsia, Malabsorption Syndrome, Gastroesophageal Reflux Disease, Abdominal Pain
- Trial name
- NCT00521703
- Testing
- Lidocaine, Tannic acid
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Infantil Cândido Fontoura
Acute Upper Gastrointestinal Hemorrhage, Acute Upper Gastrointestinal Bleeding
Clinical Investigation of Safety and Performance of a Medical Device (ClearPlasma) for the Treatment of Patients With Acute Upper Gastrointestinal Hemorrhage.
Pre-market, multi-center, international, double-blind, randomized, controlled, prospective, first-in-human clinical investigation of a Class IIb Investigational Medical Device, in which Patients presenting with acute upper…
- Trial name
- NCT04174989
- Testing
- Plasma treated with ClearPlasma (Extra-corporeal plasma filtration device), Regular fresh-frozen plasma (not treated)
- Where
- 8 sites in Czechia, Israel and 1 more
- Volunteers
- 53 people
- Sponsor
- PlasFree Ltd.
Chronic Gastrointestinal Graft vs Host Disease
Study of orBec® as Monotherapy in the Treatment of Patients With Upper GI Symptoms Caused by Chronic Graft Versus Host Disease (GVHD)
Use of an oral topically-active glucocorticoid with limited side effects may control the gastrointestinal inflammatory process of GVHD and minimize glucocorticoid exposure.
- Trial name
- NCT01925950
- Testing
- orBec
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Soligenix
Barrett Esophagus, Gastroesophageal Reflux
Demographics and Findings of Upper Endoscopy Patients
The purpose of this study is to evaluate the demographics, patients symptoms, and findings during endoscopy. Patients presenting for an endoscopy procedure to the KCVA GI endoscopy suite, will be asked to fill out questionnaires…
- Trial name
- NCT00576992
- Where
- United States
- Volunteers
- 1,177 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research