Clinical trials: Upper Gastrointestinal Disorder
Osteoporosis
Upper GI Handling of Branded vs. Generic Alendronate
To compare upper GI handling of fosamax and generic, because the main AE profile of alendronate is before systemic absorption in the esophagus; differences could be relevant to the side effect profile.
- Trial name
- NCT00400530
- Testing
- MK0217, alendronate sodium / Duration of Treatment: 1 Month, Comparator: Alendronate-Teva / Duration of Treatment: 1 Month
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
Gastrointestinal Disease, Signs and Symptoms, Digestive
Nexium Dyspepsia/AST
The aim is to evaluate if the resolution of upper abdominal symptoms (pain or burning) during an acid suppressive test trial of esomprazole given daily for 7 days predicts symptoms resolution at the end of a subsequent treatment…
- Conditions
- Gastrointestinal Disease, Signs and Symptoms, Digestive, Dyspepsia
- Trial name
- NCT00251914
- Testing
- Esomeprazole
- Where
- 215 sites in Argentina, Belgium and 15 more
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
Metastatic Colorectal Cancer
A Study Assessing Adverse Events and Disease Activity of Intravenously (IV) Infused Telisotuzumab Adizutecan in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer
Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide and in China. The purpose of this study is to assess adverse events and change in disease activity of intravenously (IV) infused telisotuzumab…
- Trial name
- NCT06614192
- Testing
- Telisotuzumab Adizutecan
- Where
- 51 sites in United States, Australia and 5 more
- Volunteers
- 74 people
- Sponsor
- AbbVie
Peptic Ulcer
AGN 201904 Versus Esomeprazole in the Prevention of Aspirin-induced Stomach or Upper Intestinal Damage in Healthy Volunteers
AGN 201904, a proton pump inhibitor, versus esomeprazole in the prevention of stomach or upper intestinal damage following administration of high-dose aspirin in healthy volunteers
- Trial name
- NCT00325715
- Testing
- AGN 201904, esomeprazole
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Allergan
UGI Bleed, Upper Gastrointestinal Bleeding
PillSense System for Detecting UGI Bleed
This is a prospective, non-randomized, open-label clinical investigation to evaluate feasibility, effectiveness and safety of the PillSense System, the transit of the PillSense Capsule through the GI tract, patient tolerability…
- Conditions
- UGI Bleed, Upper Gastrointestinal Bleeding, Upper Gastrointestinal Bleed
- Trial name
- NCT05385224
- Testing
- PillSense
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- EnteraSense Limited
Hepatitis A Vaccine
To Evaluate the Immunogenicity and Safety of Inactivated Hepatitis A Vaccine (VITHA-A)
The objective of this study is to evaluate the safety and immunogenicity after one primary dose and one additional dose (administered twice at an interval of 6 months) of inactivated hepatitis A vaccine are administered in…
- Trial name
- NCT03654677
- Testing
- inactivated hepatitis A vaccine, Havrix Inj
- Where
- 12 sites in South Korea
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Gastrointestinal Diseases
Exploratory Study of Upper and Lower Endoscopic Fuse System
Single-Center, Exploratory Study of EndoChoice's Upper and Lower Gastrointestinal Endoscopic Systems Utilizing EndoChoice's Full Spectrum Optical Technology
- Trial name
- NCT02651857
- Testing
- Fuse® Colonoscope, Fuse® Gastroscope
- Volunteers
- 1,000 people
- Sponsor
- EndoChoice Inc.
Acute Gastrointestinal Bleeding
Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute…
- Trial name
- TREET (NCT06188585)
- Testing
- UI-EWD, Conventional therapy
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 278 people
- Sponsor
- Medtronic - MITG
Chronic Gastrointestinal Graft vs Host Disease
Study of orBec® as Monotherapy in the Treatment of Patients With Upper GI Symptoms Caused by Chronic Graft Versus Host Disease (GVHD)
Use of an oral topically-active glucocorticoid with limited side effects may control the gastrointestinal inflammatory process of GVHD and minimize glucocorticoid exposure.
- Trial name
- NCT01925950
- Testing
- orBec
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Soligenix
Gastrointestinal Diseases
A Study of EndoChoice's Upper&Lower Endoscopic Systems Utilizing a Full Spectrum Optical Technology
EndoChoice's FUSE System enables a wider view range via 1-2 additional cameras (depending on the model). These optical properties are to be examined and reviewed in this trial (mainly usability and safety)
- Trial name
- FUSE (NCT02143284)
- Testing
- Endoscopy exploratory single arm (EndoChoice FUSE(TM) System)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- EndoChoice Innovation Center, Ltd.