Clinical trials: Upper Gastrointestinal Bleeding
Gastro Intestinal Bleeding
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding
This study is conducted to evaluate the effectivity of hypertonic dextrose spray as an endoscopic topical hemostatic agent, compared to conventional agent (adrenaline injection, followed by hemoclip or thermocoagulation), in…
- Trial name
- NCT04979273
- Testing
- Dextrose 40 % in Water, Adrenaline 1 Mg/mL Solution for Injection, argon plasma coagulation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Cirrhosis, Liver, Acute Upper Gastrointestinal Hemorrhage
Risk Assessment After Acute Upper Gastrointestinal Haemorrhage in Cirrhosis
In previous studies, the investigators used retrospective analysis of cases of acute upper gastrointestinal bleeding in patients with liver cirrhosis from the Fifth Medical Center of the General Hospital of Beijing PLA, China…
- Trial name
- NCT04235166
- Testing
- Current risk scores, New risk scores
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Acute Gastrointestinal Bleeding
Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute…
- Trial name
- TREET (NCT06188585)
- Testing
- UI-EWD, Conventional therapy
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 278 people
- Sponsor
- Medtronic - MITG
Peptic Ulcer
Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy
To evaluate if intravenous PPI infusion, when administered prior to endoscopy, hastens resolution of bleeding stigmata and thereby facilitates endoscopic examinations and reduces the need for endoscopic treatment.
- Trial name
- NCT00164866
- Testing
- Omeprazole
- Where
- China
- Volunteers
- 638 people
- Sponsor
- Chinese University of Hong Kong
Upper GI Bleeding
Inhalation of Sevoflurane Versus Intravenous Midazolam,Ketamine,Propofol For Pediatrics Undergoing Upper GI Endoscopy
In the field of pediatric gastroenterology, upper gastrointestinal endoscopy has established itself as a diagnostic and therapeutic tool. In order to increase patient tolerance during this procedure, deep sedation is essential.
- Trial name
- NCT05474937
- Testing
- Sevoflurane Inhalation Solution, Midazolam, Ketamine and Propofol
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Zagazig University
Bleeding UGI (During or Post-ERCP)
Incidence and Predictors of Bleeding During and Following ERCP
The incidence of bleeding during ERCP and following ERCP has been estimated using retrospective sources, but granular predictors of bleeding remain unknown, including the use of direct-acting anticoagulants and discontinuation…
- Trial name
- NCT05929404
- Where
- Canada
- Volunteers
- 5,872 people
- Sponsor
- University of Calgary
Upper Gastrointestinal Bleeding
Side Effects of Transesophageal Echocardiography
Transesophageal echocardiography is commonly used during cardiac surgery. Complications of transesophageal echocardiography are rare (1,2%), but are often underestimated and can lead to unrecognized blood loss and site of…
- Trial name
- NCT03432559
- Testing
- endoscopy
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Acute Upper Gastrointestinal Bleeding, Effect of Drug
Metoclopramide for Acute Upper GI Bleeding
The presence of blood clot in stomach limited quality of endoscopic view ,which affect successful rate of hemostatic endoscopy in patient with acute upper gastrointestinal bleeding.
- Trial name
- NCT04771481
- Testing
- Metoclopramide, Normal Saline 10 mL Injection
- Where
- 2 sites in Thailand
- Volunteers
- 68 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastrointestinal Hemorrhage
Effectiveness Study of the BioVac Direct Suction Device in Upper Gastrointestinal Bleeding
Upper endoscopy is performed for upper gastrointestinal bleeding (bleeding in the esophagus, stomach, or part of the duodenum) to identify and potentially treat the cause of bleeding.
- Trial name
- NCT02150941
- Testing
- BioVac Direct Suction Device, Standard Endoscopy Suction
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Volatile Organic Compound, Gastrointestinal Hemorrhage
Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath.
- Trial name
- VOCsAUGIB (NCT06877507)
- Testing
- Gastroscopy, Gas Chromatography - Mass Spectrometry
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital
Ulcer Bleeding, Upper Gastrointestinal Tract Bleeding
The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers
Non-variceal acute gastrointestinal bleeding is a common and potentially life-threatening problem. The conventional treatment of this condition is for esophagogastroduodenoscopy (OGD) for haemostasis.
- Trial name
- NCT03160911
- Testing
- Over-the-scope clip (OTSC), Conventional Endoscopic Haemostasis
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Non-variceal Upper Gastrointestinal Bleeding
Keverprazan vs Pantoprazole for the Treatment of ANVUGIB
Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a common medical emergency requiring hospitalization. The cornerstone of ANVUGIB management is effective gastric acid suppression.
- Trial name
- NCT07776730
- Testing
- Pantoprazole, Keverprazan
- Where
- China
- Volunteers
- 908 people
- Sponsor
- General Hospital of Shenyang Military Region
Upper Gastrointestinal Bleeding (UGIB)
Evaluation of ClearPlasma in Patients With Upper Gastrointestinal Bleeding.
Upper gastrointestinal hemorrhage (UGIH) is one of the most common gastrointestinal emergencies, and is associated with significant morbidity and mortality. Plas-Free aims to evaluate ClearPlasma safety in patients with UGIH.
- Trial name
- CLearPlasma (NCT06761430)
- Testing
- ClearPlasma
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- PlasFree Ltd.
Upper Gastrointestinal Bleeding
Risk Stratification of Patients Presenting With Upper Gastrointestinal Bleeding to the Emergency Department Using AIMS65 Score and Red Cell Distribution Width
The rationale of this study in UGIB patients is to assess whether the prediction of mortality and morbidity using AIMS65 score improves when used in combination with RDW in the emergency department setting.
- Trial name
- RUGBE (NCT04825977)
- Testing
- RISK STRATIFICATION USING AIMS65 SCORE AND RDW
- Where
- India
- Volunteers
- 348 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Upper Gastrointestinal Variceal Bleeding in Cirrhotic Patients
Predictive and Prognostic Significance of Age,Blood Tests,Comorbidities(ABC) Score,Cologne Watch(C-watch)Score and Rockall Score for Risk of Variceal Re-bleeding Among Cirrhotic Patients
Introduction Portal hypertension is a common complication of liver cirrhosis and is often underestimated in clinical diagnosis. The incidence of portal hypertension is approximately 20% to 98% in patients with cirrhosis (Wu et…
- Trial name
- NCT06335186
- Testing
- upper endoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Acute Upper Gastrointestinal Bleeding
Factors Predicting the Need for Endoscopic Intervention in Non-variceal Upper Gastrointestinal Bleeding
Gastrointestinal system bleedings are medical emergencies and the most common cause of hospital admissions related to digestive system diseases.
- Trial name
- NCT05979025
- Where
- Turkey (Türkiye)
- Volunteers
- 262 people
- Sponsor
- Ankara City Hospital Bilkent
Pancreatic Ductal Adenocarcinoma
Prevention of Upper Gastrointestinal Hemorrhage Using Albis® in the Patients of Locally Advanced Pancreatic Cancer Who Underwent Concurrent Chemoradiotherapy
Pancreatic ductal adenocarcinoma is the fourth cause of death in the Western world. About 40% of pancreatic cancer patients were diagnosed as locally advanced unresectable status without distant metastasis.
- Trial name
- NCT02570529
- Testing
- Albis®
- Sponsor
- Yonsei University
Gastrointestinal Hemorrhage (Clinically Important, Upper)
Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial
Patients who are critically ill in the in the Intensive Care Unit (ICU), especially those who need a breathing machine, can develop ulcers in the stomach that bleed.
- Trial name
- REVISE (NCT03374800)
- Testing
- Pantoprazole
- Where
- 67 sites in United States, Australia and 6 more
- Volunteers
- 4,800 people
- Sponsor
- McMaster University
Tumor of Pancreas, Surgical Blood Loss
Enucleation of Pancreatic Tumor by Blocking Abdominal Trunk and Superior Mesenteric Artery
Pancreatic enucleation could preserve more healthy pancreatic tissues and functions with a low recurrence risk. However, conventional enucleation can cause significant intraoperative bleeding, especially in which tumors in the…
- Trial name
- NCT06164769
- Testing
- blocking both the abdominal trunk and superior mesenteric artery in the pancreatic enucleation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Upper Gastrointestinal Bleeding
Randomized Trial of Outpatient vs. Inpatient Management of Low-risk Patients With Upper Gastrointestinal Bleeding.
Patients presenting to the emergency room with upper gastrointestinal bleeding and a Glasgow Blatchford score of zero will be randomly assigned to further care in the inpatient vs. outpatient setting.
- Trial name
- NCT02005705
- Testing
- Outpatient Management of Low-risk Patients, Inpatient Management of Low-risk Patients
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University