Clinical trials: Upper Extremity Paresis
Stroke, Stroke, Acute
Safety Evaluation of the ReWalk ReStore Device in Subjects With Mobility Impairments Due to Stroke
A multi-site, interventional, non-comparative, single-arm trial to evaluate the safety of the ReWalk ReStore device in subjects with hemiplegia/hemiparesis due to ischemic or hemorrhagic stroke.
- Conditions
- Stroke, Stroke, Acute, Stroke Hemorrhagic, Hemiparesis
- Trial name
- NCT03499210
- Testing
- ReWalk ReStore device
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- ReWalk Robotics, Inc.
Stroke, Cerebrovascular Accident (CVA)
Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke
The purpose of this study is to evaluate if multiple therapy sessions of Transcutaneous Vagus Nerve Stimulation (tVNS) combined with robotic arm therapy lead to a greater functional recovery in upper limb mobility after stroke…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis
- Trial name
- tVNS (NCT03592745)
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Northwell Health
Ischemic Stroke
Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm
The aim of the present clinical phase IV study is to estimate the influence of Cerebrolysin in combination with standard therapy on the dynamics of recovery of the paretic upper limb in patients with acute ischemic stroke.
- Trial name
- NCT02581371
- Testing
- Cerebrolysin infusion
- Where
- 2 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Clinical Institute of the Brain, Russia
Stroke, Physical Disability
Neuroplasticity With Daily Use of a Sensorimotor Priming Vibration System to Improve Hand Function After Stroke
More than 4 million stroke survivors in the U.S. suffer from post-stroke sensorimotor hand disability, which is typically permanent and difficult to treat.
- Trial name
- NCT04026399
- Testing
- peripheral vibration stimulation, therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Hemiparesis
A Music-based VR Intervention for Upper Limb Motor Rehabilitation in Hemiparetic Patients
Hemiparesis affects the majority of stroke patients in the acute phase. In post-stroke motor rehabilitation patients can re-learn motor sequences through repetitive training.
- Trial name
- NCT04977609
- Testing
- VR+MUSIC, VR, TAU
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Catholic University of the Sacred Heart
Stroke, Upper Extremity Paresis
Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study
The aim of this comparative and reliability study is to highlight a deficit in the use of vibrotactile sensory feedback (haptic effect) in the planning and execution of fine manual dexterity movements after stroke.
- Conditions
- Stroke, Upper Extremity Paresis, Manual Dexterity, Sensory Integration Dysfunction
- Trial name
- HapticS (NCT06344221)
- Testing
- Dextrain Manipulandum and haptic feedback device
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Stroke, Upper Extremity Paresis
tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia
After a stroke, it is very common to lose the ability to open the affected hand. Occupational and physical rehabilitation therapy (OT and PT) combined with non-invasive brain stimulation may help a person recover hand movement.
- Conditions
- Stroke, Upper Extremity Paresis, Hemiplegia
- Trial name
- NCT05866003
- Testing
- Active conventional tDCS montage plus CCFES, Active unconventional tDCS montage plus CCFES, CCFES with Occupational Therapy
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- MetroHealth Medical Center
Stroke, Upper Extremity Paresis
Transcutaneous Vagus Nerve Stimulation for Motor Recovery After Stroke
This study will evaluate the safety and effectiveness of Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) for improving motor recovery after stroke.
- Trial name
- NCT03292159
- Testing
- Active RAVANS concurrent with arm motor training, Inactive RAVANS concurrent with arm motor training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Stroke, Ischemic, Stroke
Validation of a Brain-Computer Interface for Stroke Neurological Upper Limb Rehabilitation
The study's main goal is to determine if clinical and physiological effects of a brain-computer interface intervention for the neurorehabilitation of stroke patients' upper limb are greater than the effects of a sham robotic…
- Trial name
- NCT04724824
- Testing
- Brain-Computer Interface
- Where
- Mexico
- Volunteers
- 23 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Stroke, Upper Extremity Paresis
The Efficacy of Upper Limb Rehabilitation With Exoskeleton in Patients With Subacute Stroke.
Loss of arm function is a common and distressing consequence of stroke. Neurotechnology-aided rehabilitation could be a promising approach to accelerate the recovery of upper limb functional impairments.
- Trial name
- PowerUPS-REHAB (NCT04697368)
- Testing
- Exoskeleton-Assisted Upper Limb Rehabilitation, Traditional Upper Limb Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 94 people
- Sponsor
- IRCCS San Raffaele Roma
Upper Extremity Paresis, Hemiplegia and/or Hemiparesis Following Stroke
Task or Virtual Reality Intervention for Improving UE Function
People with one arm that does not function well due to a stroke, head injury, or cerebral palsy, and a fully functional other arm, will be randomly assigned to receive one of the two interventions first, followed by the other…
- Conditions
- Upper Extremity Paresis, Hemiplegia and/or Hemiparesis Following Stroke, Hemiplegic Cerebral Palsy
- Trial name
- NCT03811275
- Testing
- Virtual Reality (A) then Task (B), Task (B) then Virtual Reality (A)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Idaho State University
Transcranial Magnetic Stimulation, Stroke
Investigating the Use of a Brain-computer Interface Based on TMS Neurofeedback for Upper Limb Stroke Rehabilitation
The mechanisms and effectiveness of a technique to boost the brain's recovery mechanisms will be studied. Brain-Computer Interface (BCI),based on applying magnetic pulses (Transcranial Magnetic Stimulation, TMS) to the stroke…
- Conditions
- Transcranial Magnetic Stimulation, Stroke, Stroke Rehabilitation, Upper Extremity Paresis
- Trial name
- NCT06164912
- Testing
- Transcranial Magnetic Simulation with Pseudofeedback, Transcranial Magnetic Simulation with Neurofeedback
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- University of Dublin, Trinity College
The Effectiveness of Novel Rehabilitation Device on Upper Limb Impairment Among Patients With Stroke
Usability and Effectiveness of a Novel Bilateral Upper Limb Training Device for Stroke Patients With Hemiparesis: A Preliminary Study
Background and Study Aims Stroke is a leading cause of long-term disability worldwide, affecting millions of individuals each year.
- Trial name
- Synslai (NCT06956677)
- Testing
- Novel UE rehabilitation device training, The UE functional training, Conventional occupational therapy
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke
Mirror Therapy: Effects on Functional Recuperation of Severe Upper Limb Paresis After Stroke
After stroke, patients frequently suffer from arm or hand weakness. There are numerous rehabilitation methods to stimulate recovery, amongst which mirror therapy (MT).
- Trial name
- MT (NCT02949609)
- Testing
- Mirror Therapy, Control Therapy
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Geneva
Stroke, Upper Extremity Paresis
rTMS Combined With Motor Training for the Treatment of Upper Limb Motor Dysfunction in Stroke Patients
The goal of this clinical trials is to investigate the effectiveness of online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke.
- Trial name
- NCT06752499
- Testing
- Online stimulation, Offline stimulation
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Stroke, Hemiparesis
Effectiveness of Multichannel Functional Electrical Stimulation
The purpose of this pilot study is to determine whether two weeks of multi-channel FES along with task-specific training will improve UE function when compared to traditional rehabilitation or usual care.
- Trial name
- NCT04876703
- Testing
- Multichannel Functional electrical stimulation, Standard motor training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Stroke, Stroke Hemorrhagic
Hand MOtor Rehabilitation Using a EMG-biofeedback: a Cross-sectional Study
Recovery of upper limb and hand gestures is fundamental for autonomy restoration after stroke. Innovative technologies are a valid support for the delivery of rehabilitation treatments.
- Conditions
- Stroke, Stroke Hemorrhagic, Stroke, Ischemic, Hemiparesis
- Trial name
- MORE (NCT04889586)
- Testing
- EMG-biofeedback armband (REMO)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Stroke, Upper Extremity Paresis
NIBS With mCIMT for Motor and Functional Upper Limb Recovery in Stroke Patients.
Stroke is one of the leading causes of serious long-term impairment. According to the estimates, 12,500 people suffer a new or recurrent ischemic stroke in Chile annually, which shows the magnitude of the problem.
- Conditions
- Stroke, Upper Extremity Paresis, Electric Stimulation, Occupational Therapy
- Trial name
- NCT03452254
- Testing
- Active Bihemispheric Transcranial direct current Stimulation, Modified Constraint Induced Movement Therapy
- Where
- 2 sites in Chile
- Volunteers
- 70 people
- Sponsor
- University of Chile
Cerebral Palsy, Motor Deficits
Constraint-Based Therapy to Improve Motor Function in Children With Cerebral Palsy
Pediatric Constraint-Induced (CI) Movement therapy is a rehabilitation program designed to improve motor function in children with partial paralysis.
- Trial name
- NCT00061139
- Testing
- Pediatric Constraint-Induced Movement therapy, Conventional pediatric motor rehabilitation therapy
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Stroke
Transcranial Galvanic Stimulation After Stroke
Transcranial galvanic stimulation (tDCS) seems to promote motor recovery after stroke by stimulating (anodal) or inhibiting (cathodal) neural circuits in the brain.
- Trial name
- TraGAT (NCT00407667)
- Testing
- transcranial galvanic stimulation
- Where
- 3 sites in Germany, Italy
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany