Clinical trials: Upper Extremity Dysfunction
Parkinson's Disease, Somatosensory Disorders
Somatosensory Dysfunction as the Underlying Mechanism of Upper Limbs Motor Blocks in People With Parkinson's Disease
Motor blocks during gait and upper limb movements (FOULs) are a disabling and common motor impairment in mild to severe stages of Parkinson's disease (PD).
- Trial name
- NCT02610257
- Testing
- Mechanical stimulus (vibration) applied on the forearm
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson Disease, Upper Extremity Dysfunction
Leap Motion Controller on the Functionality of Upper Limbs in Parkinson's Disease
Is treatment with the Leap Motion Controller device effective for upper limb functionality in individuals with Parkinson's Disease? The present study presents two hypotheses: True hypothesis: There is an improvement in the…
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Therapy-Related MDS
- Trial name
- NCT04796246
- Testing
- Leap Motion Controller, Conventional Physiotherapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Breast Cancer, Upper Extremity Dysfunction
KİNECT® - Video Games Based Physiotherapy Programme in Patients With Breast Cancer Surgery
The main objective of the study is to investigate the effects of Kinect® video based technology on pain, functionality, muscle strength, fatigue and quality of life in patients with breast cancer surgery and axillary node…
- Conditions
- Breast Cancer, Upper Extremity Dysfunction, Mastectomy
- Trial name
- NCT03618433
- Testing
- study group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Acibadem University
Allografts, Rejection; Transplant, Kidney
A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant
The purpose of this study is to evaluate the efficacy, safety and tolerability of dual costimulation blockade with VIB4920 in combination of belatacept in adult male or female recipients of a renal allograft from a deceased…
- Conditions
- Allografts, Rejection; Transplant, Kidney, Transplant Rejection, Kidney Transplantation
- Trial name
- NCT04046549
- Testing
- Belatacept, VIB4920, Thymoglobulin
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Amgen
Breast Cancer, Upper Extremity Dysfunction
Exercise Rehabilitation Via a Mobile Application for Individuals With Breast Cancer Undergoing Chemotherapy
The primary purpose of this study is to determine the feasibility of our proposed intervention approach involving (1) an integrated physiotherapy and exercise intervention for individuals with breast cancer who are undergoing…
- Trial name
- Empower (NCT05254678)
- Testing
- general exercise
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Postoperative Delirium, Postoperative Recovery in Elderly Patients
Recovery After Upper Extrimety Surgery
The goal of this randomized clinical trial is to determine whether Bispectral Index (BIS)-guided general anesthesia improves postoperative cognitive recovery and overall quality of recovery in adults undergoing elective hand or…
- Conditions
- Postoperative Delirium, Postoperative Recovery in Elderly Patients, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- Recovery (NCT07714928)
- Testing
- BIS-Guided General Anesthesia, Clinically Guided General Anesthesia
- Where
- Sweden
- Volunteers
- 112 people
- Sponsor
- Region Örebro County
Upper Extremity Dysfunction, Traumatic Brain Injury
Targeted Noninvasive Brain Stimulation (T-NIBS) to Improve Hand Motor Functions in Acquired Brain Injury
Acquired Brain Injury (TBI) is a serious medical and health problem in the US. Individuals with an acquired brain injury due to stroke and Traumatic Brain Injury (TBI) commonly suffer from upper extremity physical impairments…
- Trial name
- NCT04057105
- Testing
- Active High-definition Transcranial Direct Current Stimulation (HD-tDCS), MusicGlove
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Kessler Foundation
Upper Extremity Dysfunction, Stroke
taVNS Paired With Motor Training for Upper-extremity Rehabilitation in Stroke Patients
Background: Recently, there has been increasing attention on the application of transcutaneous auricular vagus nerve stimulation (taVNS) in ischemic stroke.
- Trial name
- NCT05943431
- Testing
- paired taVNS, Unpaired taVNS
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Qiuyou Xie
Multiple Sclerosis, Urinary Bladder, Overactive
Wearables for the Bladder: an In-home Treatment Feasibility Pilot Study
The goal is to investigate the feasibility and effects of adding "wearables for the bladder" devices to conventional pelvic floor physical therapy (PFPT) to bladder function, in people with multiple sclerosis (MS).
- Trial name
- WeB (NCT05715268)
- Testing
- WeB, Standard pelvic floor physical therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Stroke
The Impact of App-based Cognitive Training on Post-stroke Upper Extremity Rehabilitation
To find out the impact of app-based cognitive training on upper extremity function in patients with sub-acute stroke.
- Trial name
- NCT05951530
- Testing
- traditional physical therapy, mobile app-based cognitive training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Schizophrenia
A Study of the Effect of RO4917838 on Biomarker Measures of Cognitive Dysfunction in Participants With Schizophrenia and Schizoaffective Disorder
This randomized, double-blind, placebo-controlled parallel group study will assess the effect on biomarkers measures of cognitive dysfunction, the clinical efficacy and safety of RO4917838 in participants with schizophrenia and…
- Trial name
- NCT01116830
- Testing
- RO4917838, Standard Antipsychotic Therapy
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hoffmann-La Roche
Cerebral Palsy Infantile, Chronic Pain
Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children
The goal of this clinical trial is to test the effectiveness of a trunk and upper extremities exercise program. The main questions it aims to answer are: Whether the program decreases compensation patterns in unilateral cerebral…
- Conditions
- Cerebral Palsy Infantile, Chronic Pain, Upper Extremity Dysfunction
- Trial name
- TUPEX (NCT06069765)
- Testing
- TUPEX
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundacio Aspace Catalunya
Stroke, Transcranial Magnetic Stimulation
Effects of Individualized Accurate Positioning TMS Based on Task fMRI Activation on Upper Extremity Function After Stroke
Stroke is a global health problem and a leading cause of disability. Limitation of upper limb function occurs in 55 -75% of patients after stroke.
- Conditions
- Stroke, Transcranial Magnetic Stimulation, Functional Magnetic Resonance Imaging, Upper Extremity Dysfunction
- Trial name
- NCT05440292
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cancer of the Prostate, Cancer
Cognitive Remediation Therapy (CRT) for Adults Treated for Cancer
This study is to determine the safety, feasibility and acceptability of an 8-week cognitive remediation training (CRT) in patients treated for cancer.
- Trial name
- CaCRT (NCT03285048)
- Testing
- Cognitive Remediation Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Stroke, Amyotrophic Lateral Sclerosis
Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation
This interventional, multicenter, low-intervention clinical trial aims to evaluate the usability, feasibility, safety, and preliminary clinical impact of a robotic rehabilitation system designed for upper limb rehabilitation in…
- Conditions
- Stroke, Amyotrophic Lateral Sclerosis, PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)
- Trial name
- ASULDAR (NCT07636538)
- Testing
- Auto-calibrating System for Upper Limb disability Assessment, neurological and occupational Rehabilitation, conventional therapy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Mild Cognitive Impairment (MCI)
Effects of Hydroxytyrosol-Rich Olive Polyphenol Dietary Supplement Combined With Mediterranean Diet Adherence on the Cognitive Health of Patients With Mild Cognitive Impairment
Nutrition is an important modifiable risk factor of human cognitive health. Increasing data suggests that certain nutrients or food ingredients, such as plant polyphenols, have the potential to benefit cognitive abilities even in…
- Trial name
- MEDIPHENO-HT (NCT07672938)
- Testing
- Low-Dose Hydroxytyrosol-Rich Olive Juice Polyphenol Supplement, High-Dose Hydroxytyrosol-Rich Olive Juice Polyphenol Supplement
- Where
- Greece
- Volunteers
- 141 people
- Sponsor
- Panhellenic Federation of Alzheimer's Disease and Related Disorders
Breast Cancer
Non-Invasive Imaging for Cording in Breast Cancer Patients
To date, the scientific literature has yet to provide sufficient evidence regarding the pathophysiology of cording. The objective of this protocol is to evaluate the utility of non invasive vascular imaging for assessing the…
- Trial name
- NCT01427166
- Testing
- Non invasive venous ultrasound
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Erectile Dysfunction
Study the Effect of Avanafil on the Pharmacodynamics and Pharmacokinetics of Warfarin in Healthy Male Subjects
This study is designed to look into the effect of avanafil on blood levels of warfarin and to investigate its effect on prothrombin time/international normalized ratio (INR) in healthy men.
- Trial name
- NCT01095588
- Testing
- 200 mg Avanafil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC