Clinical trials: Upper Extremity
Head and Neck Squamous Cell Carcinoma, Neoadjuvant Therapy
Neoadjuvant PD-1 Inhibitor Combined With Cetuximab in Operable Locally Advanced HNSCC
This is a single-center, single-arm, phase II clinical study to evaluate the efficacy and safety of PD-1 inhibitor combined with cetuximab in neoadjuvant therapy for locally advanced HNSCC.
- Trial name
- PC-1 (NCT05993858)
- Testing
- 3cycles (Toripalimab + cetuximab), Surgery, Radiotherapy or chemoradiotherapy
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Stroke
Active Somatosensory Exercise for Chronic Stroke
The current work aims to examine whether the proposed rehabilitation training or exercise will eventually yield improvements in both motor and somatosensory aspects at one goal.
- Trial name
- ActSens (NCT04490655)
- Testing
- Active somatosensory training, Motor-based training
- Where
- 2 sites in Singapore
- Volunteers
- 9 people
- Sponsor
- Nanyang Technological University
Immune Thrombocytopenia, Autoantibodies
Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies
This prospective, open-label, single-center, one-arm clinical trial aims at evaluating the efficacy and safety of avatrombopag in Chinese adult Immune Thrombocytopenia (ITP) patients with autoantibodies fail (due to intolerance…
- Conditions
- Immune Thrombocytopenia, Autoantibodies, Evan Syndrome, Connective Tissue Diseases
- Trial name
- NCT04993885
- Testing
- Avatrombopag
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Psychological Stress, Sleep Disturbance
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceived stress, sleep disturbance, mood, anxiety, depressive symptoms, happiness, and occupational burnout in…
- Conditions
- Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms
- Trial name
- NM90 (NCT07717385)
- Testing
- Neuralli Mood
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Esophageal Squamous Cell Carcinoma
Combination of Toripalimab and Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Radical resection is thought to be the mainstay of esophageal cancer treatment. Neoadjuvant chemoradiotherapy (CRT) followed by surgery has become the standard treatment option for locally advanced esophageal squamous cell cancer…
- Trial name
- NCT04644250
- Testing
- Toripalimab, Paclitaxel liposome/Carboplatin, Intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Wei Ren
Homozygous Familial Hypercholesterolemia HoFH
Safety and Tolerability of Repatha® (Evolocumab) in Indian Participants With Homozygous Familial Hypercholesterolemia
To describe the safety and tolerability of evolocumab in participants with homozygous familial hypercholesterolemia (HoFH) in India. All participants will receive evolocumab over an 8-week period.
- Trial name
- RAMAN (NCT03403374)
- Testing
- evolocumab
- Where
- 12 sites in India
- Volunteers
- 30 people
- Sponsor
- Amgen
Parkinson's Disease
An Unblinded, Single Arm, Pilot Observational Study to Test the Safety, Tolerability, Immunogenicity and the Biological Effects of TRB-001 Vaccination.
An unblinded, single arm, pilot observational study to test the safety, tolerability, immunogenicity and the biological effects of TRB-001 vaccination in individuals who have previously undergone aSyn immunotherapy
- Trial name
- NCT07777484
- Testing
- TRB-001
- Where
- Austria
- Volunteers
- 6 people
- Sponsor
- Tridem Bioscience FlexCo
HCV
A Clinical Trial of 16 Weeks of Duration to Evaluate Retreatment With Elbasvir/Grazoprevir Plus Sofosbuvir and Ribavirin in Patients With Chronic Hepatitis C Genotypes 1,4 Who Have Failed to Treat With a Regime Based on an Inhibitor of the NS5A
This is a phase 4 clinical trial to treat patients who have failed to treat with regimen based on an inhibitor of the NS5A
- Trial name
- C-RESCUE (NCT03105349)
- Testing
- elbasvir/grazoprevir, Sofosbuvir, Ribavirin
- Where
- 5 sites in Spain
- Sponsor
- Fundacion SEIMC-GESIDA
Atopic Dermatitis
Safety, PK, PD, and Clinical Activity of Orally Administered KT-621 in Adult Patients With Atopic Dermatitis (AD)
This is a study to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of orally administered KT-621 in adult male and female patients with moderate to severe atopic dermatitis (AD).
- Trial name
- BroADen (NCT06945458)
- Testing
- KT-621
- Where
- 12 sites in United States
- Volunteers
- 22 people
- Sponsor
- Kymera Therapeutics, Inc.
Arteriovenous Fistula, Ultrasound
Relationship Between Arterial Variations and Patency of Arteriovenous Fistulae
In 2019, KDOQI considered that uremic patients with a life expectancy of more than one year should require hemodialysis as an effective renal replacement therapy before preparation of kidney transplantation.
- Conditions
- Arteriovenous Fistula, Ultrasound, Artery
- Trial name
- NCT04613115
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Atrial Septal Defect
Cera™ ASD Occluder Post-Market Clinical Follow-Up Study
The objective of this post-market study is to: collect real-word clinical data and confirm the long-time safety and performance of the Lifetech Cera™ ASD Occluder identify previously unknown side-effects
- Trial name
- NCT06849635
- Where
- 6 sites in Poland
- Volunteers
- 139 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Soft Tissue Sarcoma
Apatinib Mesylate Combined With Doxorubicin and Ifosfamide in Advanced Soft-tissue Sarcoma
Apatinib mesylate is a multitarget receptor tyrosine kinase inhibitor. This trial is to evaluate the efficacy and safety of apatinib mesylate combined with doxorubicin and ifosfamide in the treatment of advanced soft tissue…
- Trial name
- NCT04012827
- Testing
- Apatinib Mesylate, doxorubicin, ifosfamide
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sun Yat-sen University
Infertility
Diafert® for Embryo Selection and Fertility Improvement
Prospective, single-center, single-blind, randomized, controlled, two-arm, interventional study.
- Trial name
- DESTINy (NCT02593461)
- Testing
- Daifert, Control Group
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Forest Laboratories
Dementia
Memory Study of Youngest Women Enrolled in the Women's Health Initiative Hormone Therapy (HT) Arm
WHIMS-Y provides valuable information on the long-term effects on risk of cognitive impairment of hormone therapy in a subset of WHI participants in the WHI Hormone Trials.
- Trial name
- WHIMS-Y (NCT01124773)
- Where
- United States
- Volunteers
- 1,362 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Tennis Elbow, Epicondylitis, Lateral Humeral
Relationships Between Ultrasound Data and the Impact of Lateral Epicondylar Pain
Our primary objective is to study the relationship between ultra sound data and the pain associated with tennis elbow.
- Trial name
- EPICORE (NCT01390454)
- Testing
- Ultrasound of the elbow 1, days 7 to 15, Ultrasound of the elbow 2, days 7 to 15, Ultrasound of the elbow 3, days 45 to 90
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Myelomonocytic Leukemia (CMML)
Thiotepa-Containing Conditioning Regimen for Allogeneic HSCT in Chronic Myelomonocytic Leukemia
This is a prospective, single-arm clinical study. It aims to evaluate the effectiveness and safety of a conditioning regimen containing thiotepa (in combination with busulfan and fludarabine, with or without ATG) of allogeneic…
- Trial name
- NCT07588594
- Testing
- TBF regimen
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Peking University People's Hospital
Dermatitis Atopic
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis
This is a parallel group, Phase 3, multinational, multicenter, randomized, double blind, placebo-controlled, 3-arm monotherapy study for treatment of participants diagnosed with moderate to severe atopic dermatitis (AD), whose…
- Trial name
- COAST 1 (NCT06130566)
- Testing
- Amlitelimab
- Where
- 148 sites in United States, Argentina and 13 more
- Volunteers
- 601 people
- Sponsor
- Sanofi
Stroke, Spinal Cord Injuries (Complete and Incomplete)
EMG-Directed Virtual-Reality Training for Motor Stroke Rehabilitation
This study is testing whether rehabilitation using muscle activity signals can help improve arm and hand movement in people after stroke or spinal cord injury.
- Trial name
- NCT07705256
- Testing
- Visual EMG feedback with vibrotactile feedback, Visual EMG feedback
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Vomiting, Nausea Post Chemotherapy
Aprepitant for Nause and Vomiting Induced by Chemoradiotherapy in HNSCC
To evaluate the safety and efficacy of aprepitant combined with ondansetron and dexamethasone to prevent nausea and vomiting induced by Intensity-modulated Radiotherapy (IMRT) cisplatin-chemotherapy regimen in locally advanced…
- Conditions
- Vomiting, Nausea Post Chemotherapy, Head Neck Cancer
- Trial name
- NCT03572829
- Testing
- Aprepitant
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Chinese Academy of Medical Sciences
Arthroscopic Rotator Cuff Repair
Comparison Between Abduction External Rotation Brace and Arm Sling After Arthroscopic Rotator Cuff
Comparison between Abduction External Rotation Brace and Arm Sling after Arthroscopic Rotator Cuff : A Randomized Controlled Trial Comparison of primary outcome : range of motion (at pre-operative , post-operative) , pain score …
- Trial name
- ARCR (NCT05948995)
- Testing
- Abduction external rotation brace
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand