Clinical trials: Uncontrolled Hypertension, open to volunteers
Uncontrolled Hypertension
Remote Hypertension Management for Black Patients
This study will compare two approaches for managing hypertension in Black patients with uncontrolled blood pressure (BP). One approach will include home BP telemonitoring supported by a pharmacist and a community health worker.
- Trial name
- RHYTHM-B (NCT06527794)
- Testing
- RHYTHM (Remote Hypertension Tracking Help Management), Enhanced usual care (UC)
- Where
- United States
- Volunteers
- 864 people
- Sponsor
- Wake Forest University Health Sciences
Uncontrolled Hypertension
Netrod-Pilot Study of Renal Denervation With NetrodTM Sixelectrode Radiofrequency RDN System
This single-arm, non-randomized, open-label investigation aims to collect safety and efficacy data of the CE-Marked Netrod™ RDN System in treating European patients with primary hypertension in the absence of anti-hypertensive…
- Trial name
- NCT07061054
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Uncontrolled Hypertension
Sequential Multiple Assignment Randomized Trial to Reduce Food Insecurity
Food insecurity affects 20% of the 116 million people in the US with hypertension and is associated with poor adherence to evidence-based treatments and disparities in hypertension outcomes.
- Trial name
- SMART (NCT07031739)
- Testing
- Resource information, Community Health Worker (CHW) assistance, Medically-tailored Meals (MTM)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Wake Forest University Health Sciences
Uncontrolled Hypertension
SAL0140 Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Healthy Chinese Population
The purpose of this study is to evaluate the safety, tolerability pharmacokinetics and pharmacodynamics of SAL0140 healthy Chinese population.
- Trial name
- NCT07051603
- Testing
- SAL0140
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Hypertension, Uncontrolled Hypertension
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension
- Trial name
- NCT07090161
- Testing
- iloperidone
- Where
- 28 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanda Pharmaceuticals
Uncontrolled Hypertension
Implementation of Effective Hypertension Management Approaches: OSF HealthCare
The goal of this observational pragmatic study is to learn about how evidence-based interventions and best practices for management of uncontrolled hypertension can be integrated across a large healthcare system through the use…
- Trial name
- NCT07450222
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Colleen J Klein
Normal Blood Pressure, Controlled Hypertension
Wearable Evaluation of Ambulatory Readings for Blood Pressure
The purpose of this project is to compare the performance and validity of novel wearable technologies that measure blood pressure (BP) and physical activity with a Spacelabs Ambulatory Blood Pressure Monitoring (ABPM) device.
- Conditions
- Normal Blood Pressure, Controlled Hypertension, Uncontrolled Hypertension
- Trial name
- WEAR-BP (NCT06610448)
- Testing
- ABPMPro, Spacelabs Ambulatory Blood Pressure Monitoring, Aktiia Blood Pressure
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stephen Juraschek
Hypertension, Vascular Diseases
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
The purpose of the SPYRAL SWYFT sub-study is to evaluate whether renal denervation with the Symplicity Spyral system performed in the main and first order branch renal arteries yields a shorter procedure time and is as effective…
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- SWYFT (NCT07115953)
- Testing
- Symplicity Spyral™ multi-electrode renal denervation system
- Where
- 21 sites in Australia, Belgium and 7 more
- Volunteers
- 130 people
- Sponsor
- Medtronic Vascular
ASCVD, Hyperlipidemia
Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors
This project is studying whether a team-based specialty clinic can help people with type 2 diabetes and heart disease better manage their blood pressure and cholesterol.
- Conditions
- ASCVD, Hyperlipidemia, Hypertension
- Trial name
- DUKE PREVENT (NCT07117695)
- Testing
- Referral to the Duke Cardiometabolic Prevention Clinic
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Glaucoma, Open Angle
SCTSC Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients
cyclodiode versus trabeculectomy with MMC in pseudophakic patients.
- Trial name
- NCT07152132
- Testing
- Trabeculectomy, Slow coagulation trans-scleral cyclophotocoagulation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Mild-to-moderate Essential Hypertension
A Phase III Clinical Trial Evaluating the Efficacy and Safety of Valsartan/Levamlodipine (SYH9056) Tablets In Hypertensive Patients
SYH9056 tablets are a combination of valsartan and levamlodipine maleate. This is a multicenter, randomized, double-blind, parallel-controlled phase III study, designed to validate the efficacy and safety of SYH9056 tablets in…
- Trial name
- NCT06771245
- Testing
- SYH9056, Levamlodipine, Valsartan
- Volunteers
- 606 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Hypertension
A Study to Investigate Efficacy and Safety of a TCA108 in Participants ≥18 Years With Uncontrolled Hypertension
The purpose of this study if to evaluate the efficacy and safety of TCA108 on treatment of hypertension.
- Trial name
- TRÍADE-HA (NCT07030101)
- Testing
- TCA108, Bramicar HCT, Micardis Anlo
- Volunteers
- 400 people
- Sponsor
- EMS
Hypertension,Essential, Hypertension, Uncontrolled
Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System
The CHARGE-APP project will investigate whether an innovative management strategy of hypertension based on the combination of usual care visits and ESH CARE App compared to standard care, is associated with differences in…
- Trial name
- CHARGE-APP (NCT03206814)
- Testing
- Usual care, POST-strategy
- Where
- 8 sites in Argentina, China
- Volunteers
- 480 people
- Sponsor
- Istituto Auxologico Italiano
Hypertension
Effectiveness and Cost-Effectiveness of a Digital Care Pathway and Asynchronous Communication for Patients With Hypertension
The goal of this clinical trial is to learn if digital care pathway (DCP) and digital non-real-time messaging, in other words, asynchronous communication (AC) with nurse works to treat high blood pressure in adults in primary…
- Trial name
- DEPTH (NCT07812350)
- Testing
- Digital care pathway for hypertension, Asynchronous communication with nurse
- Where
- 6 sites in Finland
- Volunteers
- 600 people
- Sponsor
- Wellbeing Services County of Pirkanmaa
Hypertension, Uncontrolled Hypertension
SMART Study in Real World
This study is a multicenter, single-arm, open-label and post-market study in a real world patient population with uncontrolled hypertension to document the long-term safety and efficacy of a renal mapping/selective renal…
- Conditions
- Hypertension, Uncontrolled Hypertension, Resistant Hypertension, Reduce Antihypertensive Drug Burden
- Trial name
- SMART-RW (NCT06780696)
- Testing
- SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- SyMap Medical (Suzhou), Ltd.
Uncontrolled Hypertension
A Phase IIIb Study to Investigate the Effect of Baxdrostat in Chinese Participants With Uncontrolled Hypertension.
This is a Phase IIIb, multicentre, randomised, double-blind, placebo-controlled, parallel group study to evaluate the effect of baxdrostat 2mg versus placebo, administered QD orally, on the reduction of ambulatory 24-hour average…
- Trial name
- BaxNoD (NCT07686120)
- Testing
- baxdrostat 2mg
- Where
- 51 sites in China
- Volunteers
- 286 people
- Sponsor
- AstraZeneca
Hypertension
CART BP Pro-Guided Blood Pressure Management for Uncontrolled Hypertension
This multicenter, prospective, open-label randomized controlled trial evaluates the efficacy and safety of CART BP Pro-guided blood pressure management in Korean patients with uncontrolled hypertension.
- Trial name
- CART-BP RCT (NCT07465549)
- Testing
- CART BP Pro, Usual Care
- Where
- 3 sites in South Korea
- Volunteers
- 400 people
- Sponsor
- Korea University Anam Hospital
Uncontrolled Hypertension, Resistant Hypertension
A Study Evaluating the Efficacy and Safety of SYH2072 Tablets In Hypertensive Patients
SYH2072 is a highly selective aldosterone synthase inhibitor. This is a multicenter, randomized, double-blind, placebo-controlled Phase II study designed to evaluate the efficacy and safety of SYH2072 tablets in patients with…
- Trial name
- NCT07911735
- Testing
- SYH2072 Tablets
- Volunteers
- 264 people
- Sponsor
- InnovStone Therapeutics Limited
Uncontrolled Hypertension
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
The purpose of this clinical trial is to measure the safety and efficacy of RTN-001 in adult participants with uncontrolled hypertension versus placebo.
- Trial name
- NCT07142356
- Testing
- RTN-001
- Where
- 44 sites in United States
- Volunteers
- 280 people
- Sponsor
- Retension Pharmaceuticals. Inc.
Uncontrolled Arterial Hypertension
Prediction of Blood Pressure Outcomes Following Renal Denervation (PREDICT-RDN)
Prospective, single arm trial to assess the effects of renal denervation on day-by-day blood pressure measurements and time in blood pressure target range, as well as establish a multivariate prediction model for blood pressure…
- Trial name
- PREDICT-RDN (NCT06845579)
- Testing
- Renal sympathetic denervation
- Where
- 2 sites in Germany
- Volunteers
- 90 people
- Sponsor
- Heart Center Leipzig - University Hospital