Clinical trials: Uncontrolled Hypertension
Hypertension
Efficacy/Safety of Amlodipine Plus Losartan Versus Amlodipine in Patients With Essential Hypertension
The purpose of this study is to evaluate of efficacy and safety of amlodipine plus losartan and amlodipine alone in patients with essential hypertension inadequately controlled on amlodipine monotherapy.
- Trial name
- NCT00940667
- Testing
- Amlodipine plus Losartan, Amlodipine
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension, Hypertension, Resistant to Conventional Therapy
RADIANCE Continued Access Protocol
RADIANCE CAP is a non-randomized study designed to allow for continued access to ultrasound renal denervation therapy via the Paradise System, and to allow for the on-going collection of safety and effectiveness data in subjects…
- Conditions
- Hypertension, Hypertension, Resistant to Conventional Therapy, Vascular Diseases, Cardiovascular Diseases
- Trial name
- RADIANCE CAP (NCT05017935)
- Testing
- Renal Denervation
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- ReCor Medical, Inc.
Uncontrolled Hypertension, Cardiovascular Risk Factor
Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease
The largest epidemiologic study of Hispanic/Latino participants thus far, i.e., the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) documented that 80% of men and 71% of women have at least one major cardiovascular…
- Trial name
- NCT03221114
- Testing
- Positive Psychological Intervention
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Illinois at Urbana-Champaign
Resistant Hypertensive Patients
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
The ENSURE study is a multi-center, prospective, single-blind, randomized, controlled study of the effect of renal denervation on arterial stiffness and haemodynamics in subjects with uncontrolled hypertension.
- Trial name
- ENSURE (NCT02102126)
- Testing
- Renal denervation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 10th People's Hospital
Primary Open Angle Glaucoma
EXTERNAL SLT Treatment in Patients With Uncontrolled OPEN ANGLE GLAUCOMA
The purpose of this study is to evaluate the advantages and disadvantages of external selective laser trabeculoplasty (SLT) in treating open angle glaucoma,compared to traditional SLT.
- Trial name
- ETSG (NCT01384149)
- Testing
- external slt, standard slt
- Where
- 3 sites in Israel
- Volunteers
- 32 people
- Sponsor
- Meir Medical Center
Uncontrolled Hypertension
Uncontrolled Hypertension Management (TEAM-HTN)
Current guideline directed medical therapies (GDMT) for hypertension (HTN) endorse a trial and error approach based on drug class.
- Trial name
- TEAM-HTN (NCT03281772)
- Testing
- Clinical Decision Software - provider portal, Clinical Decision Software - patient portal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Hypertension
Renal Denervation for Uncontrolled Hypertension
This is a study investigating the safety and usefulness of the Renal Denervation Procedure in reducing high blood pressure in people whose blood pressure is not adequately controlled despite already being treated with 2 blood…
- Trial name
- RDNP-2012-02 (NCT02016573)
- Testing
- Renal Denervation
- Sponsor
- Baker Heart and Diabetes Institute
Hypertension, Uncontrolled, Hypertension, Resistant
INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Trial (INFORM)
Our previous study (Huang HC, Pan HY, Wang TD, Circ Cardiovasc Interv 2023;16:e012779) demonstrated that when renal artery stimulation continues to trigger systolic blood pressure increases (>=20 mmHg increase compared to…
- Conditions
- Hypertension, Uncontrolled, Hypertension, Resistant, Hypertension
- Trial name
- INFORM (NCT06676553)
- Testing
- Radiofrequency ablation alone, re-denervation to main and/or branch renal artery, Radiofrequency ablation alone, no further renal denervation
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- National Taiwan University Hospital
Hypertension
Amlodipine And Olmesartan Medoxomil In Hypertensive Filipino Patients
The purpose of this study is to determine the safety, tolerability and efficacy of Amlodipine and Olmesartan medoxomil among Hypertensive Filipino patients.
- Trial name
- NCT01200407
- Testing
- Amlodipine + Olmesartan medoxomil
- Where
- 51 sites in Philippines
- Volunteers
- 615 people
- Sponsor
- Pfizer
Hypertension, Uncontrolled Hypertension
SMART Study in Real World
This study is a multicenter, single-arm, open-label and post-market study in a real world patient population with uncontrolled hypertension to document the long-term safety and efficacy of a renal mapping/selective renal…
- Conditions
- Hypertension, Uncontrolled Hypertension, Resistant Hypertension, Reduce Antihypertensive Drug Burden
- Trial name
- SMART-RW (NCT06780696)
- Testing
- SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- SyMap Medical (Suzhou), Ltd.
Arterial Hypertension
"Community-based, eHealth Supported Management of Cardiovascular Risk Factors by Lay Village Health Workers (ComBaCaL aHT TwiC 1 & ComBaCaL aHT TwiC 2)
ComBaCaL aHT TwiC 1 and aHT TwiC 2 are two cluster-randomized controlled trials that are identical in intervention, design and endpoints.
- Trial name
- NCT05684055
- Testing
- First-line antihypertensive single-pill combination (SPC), Standardized counselling and referral to the closest health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- 1,354 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiovascular Disease
Evaluation of Patients With Heart Disease Not Eligible for Research Protocols
An important mission of the National Institutes of Health (NIH) is to develop and carry out research studies designed to improve understanding of disease processes and treatments.
- Trial name
- NCT00001458
- Where
- United States
- Volunteers
- 7,829 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Uncontrolled Hypertension
REGN5381 in Adult Participants With Uncontrolled Hypertension
This study is researching an experimental drug called REGN5381 (called "study drug"). The study is focused on uncontrolled hypertension (high blood pressure despite being on one or more antihypertensive drugs).
- Trial name
- NATRIX-SBP (NCT06833190)
- Testing
- REGN5381
- Where
- 3 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- Regeneron Pharmaceuticals
Hypertension
WIreless Monitoring and Financial Incentives for Uncontrolled HYpertension (WIFHY) Study
Hypertension is a major risk factor for cardiovascular morbidity and mortality. Despite the risks of hypertension and availability of effective treatment, a substantial number of patients have uncontrolled Blood Pressure (BP).
- Trial name
- WIFHY (NCT03368417)
- Testing
- Usual Care, Wireless HBPM System, BP Monitoring Incentives
- Where
- 2 sites in Singapore
- Volunteers
- 42 people
- Sponsor
- Duke-NUS Graduate Medical School
Hypertension
Developing an Integrated System Approach for the Management of Hypertension: A Pilot Study
Hypertension has become a public health concern worldwide due to its significant contribution to the global health burden and its role as a prominent risk factor for the development of a number of chronic diseases such as…
- Trial name
- NCT02186067
- Testing
- Referral System
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- Aga Khan University
Hypertension
BP-EASE -Effectiveness of Losartan 50 mg/Hydrochlorothiazide (HCTZ) 12.5 mg Versus Valsartan 80 mg/HCTZ 12.5 mg Titrated as Needed in Patients With Essential Hypertension Not Controlled on Monotherapy (0954A-333)
To evaluate the blood pressure efficacy between losartan and valsartan at equivalent dosage during a 3 months treatment.
- Trial name
- EASE (NCT00546754)
- Testing
- losartan potassium (+) hydrochlorothiazide, Comparator: Valsartan (+) Hydrochlorothiazide
- Volunteers
- 808 people
- Sponsor
- Organon and Co
Uncontrolled Hypertension
Adrenal Artery Ablation for Uncontrolled Hypertension
The activation of the renin-angiotensin-aldosterone system (RAAS) plays a key role in uncontrolled hypertension or resistant hypertension.
- Trial name
- NCT03660397
- Testing
- Selective endovascular chemical ablation of adrenal gland, Traditional triple antihypertensive treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Third Military Medical University
Hypertension
Management of Uncontrolled Hypertension (HTN)
In this study, investigators will compare chronotherapy to ABPM. Data collected will include hypertension drug therapy regimen prior to and during the study, timing of medication administration, and dose, along with the patient's…
- Trial name
- NCT02922023
- Testing
- Ambulatory blood pressure monitor (ABPM), Chronotherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Essential Hypertension
A Clinical Study to Evaluate Efficacy and Safety of Fimasartan/Hydrochlorothiazide Combination-therapy
The purpose of this study is to evaluate the antihypertensive efficacy and safety of Fimasartan/Hydrochlorothiazide combination 60/12.5mg~120/12.5mg in patients with essential hypertension who are not controlled by fimasartan…
- Trial name
- NCT01258673
- Testing
- Fimasartan/HCTZ combination, Fimasartan
- Where
- South Korea
- Volunteers
- 263 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension
Study of Efficacy and Safety of LCZ696/Amlodipine in Grade 1 and 2 Hypertension Patients Uncontrolled by LCZ696 Monotherapy
This CLAZ696B11302 study is composed of two parts; the Core part including double-blind period, and the open-label extension (OLE) part which is an open-label extension of the Core part.
- Trial name
- NCT06236061
- Testing
- LCZ, LCZ/AML 200 mg/2.5 mg, LCZ/AML 200 mg/5 mg
- Where
- 43 sites in Japan
- Volunteers
- 718 people
- Sponsor
- Novartis Pharmaceuticals