Clinical trials: Ulcerative Colitis (UC), open to volunteers
Diarrhea Chronic, UC - Ulcerative Colitis
ND-12 Combined With H-6 for Adult Chronic Inflammatory Diarrhea
This is a randomized controlled trial to explore the efficacy and safety of ND-12 combined with H-6 for patients with chronic inflammatory diarrhea
- Trial name
- NCT07767370
- Testing
- mesalazine, ND-12, ND-12/H-6
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Ulcerative Colitis (UC), Crohn Disease
Evaluation of the Accuracy of Immunostaining of Claudin 2 to Detect Active or Inactive Inflammation in Endoscopic Biopsies of IBD
In view of the increasing evidence of the importance of mucosal healing as a combination of endoscopic and histologic healing, and the complexity and lack of complete agreement of the evaluation of histologic healing in IBD, the…
- Trial name
- LOGIC-2 (NCT07710287)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Ulcerative Colitis
Naturopathic Approaches to Ulcerative Colitis
Ulcerative colitis (UC) is a long-term condition that causes inflammation in the large intestine. People with UC often have symptoms such as diarrhea, abdominal pain, and fatigue.
- Trial name
- NCT07521904
- Testing
- Naturopathic medicine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National University of Natural Medicine
Ulcerative Colitis (UC)
Study to Evaluate the Efficacy and Safety of Ponesimod (VSP-128) in Patients With Moderately to Severely Active Ulcerative Colitis
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Ponesimod (VSP-128) in patients with moderately to severely active ulcerative colitis
- Trial name
- NCT07686081
- Testing
- Ponesimod
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Vanda Pharmaceuticals
Inflammatory Bowel Diseases, Crohn Disease
Utility of Random Biopsies in Patients With Inflammatory Bowel Disease
The proposed study is a multicenter parallel group clinical trial that will include 821 evaluable patients per group who will be randomly assigned to either high definition white light colonoscopy (HDWLC) with targeted biopsies…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- URBI (NCT06560021)
- Testing
- Biopsy strategy
- Where
- 21 sites in United States
- Volunteers
- 1,642 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Ulcerative Colitis, Inflammatory Bowel Diseases
Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population
This is a multi-centre, randomised controlled trial comparing fecal microbiota transplantation to placebo in an expanded ulcerative colitis population: a feasibility study (FRONTIER-UC) to determine whether a full-scale…
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Clostridioides Difficile Infection
- Trial name
- FRONTIER-UC (NCT07401680)
- Testing
- Lyophilized Fecal Microbiota Transplantation (LFMT)
- Where
- 2 sites in Canada
- Volunteers
- 85 people
- Sponsor
- University of Alberta
Ulcerative Colitis (UC), Ulcerative Colitis (Disorder)
A Phase I Study to Evaluate the Safety/Tolerability of BDHK-2009 Tablets in Healthy Adult
A Phase 1, 2-part, randomised, double-blind, placebo-controlled, FIH study to determine the safety, tolerability, and PK of single, ascending oral doses (SAD) of BDHK-2009 (Part 1) and multiple oral doses (Part 2) of BDHK-200 in…
- Conditions
- Ulcerative Colitis (UC), Ulcerative Colitis (Disorder), Ulcerative Colitis Acute, IBD (Inflammatory Bowel Disease)
- Trial name
- NCT07632573
- Testing
- BDHK-2009 Tablets
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Benethera (Shaoxing) Biotechnology Co., Ltd.
Crohn Disease (CD), Ulcerative Colitis (UC)
Leucine-rich α2-glycoprotein Correlation With Clinical, Endoscopic and Histological Disease Activity of IBD in a EuRopean Context
Prospectively study the correlation between Leucine-rich α2-glycoprotein (LRG) and clinical/endoscopic/histological disease activity in patients with inflammatory bowel disease (IBD) in Europe.
- Trial name
- LEADER (NCT07621783)
- Testing
- Leucine-rich α2-glycoprotein
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Imelda GI Clinical Research Center
Ulcerative Colitis (UC)
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative Colitis
A study to investigate the safety, tolerability, and pharmacokinetics (PK) of ONO-6414 orally in healthy adult participants and in patients with active ulcerative colitis (UC).
- Trial name
- NCT07749768
- Testing
- ONO-6414
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Crohn Disease (CD), Ulcerative Colitis (UC)
TIDHI Mental Health in IBD Patients Study
The purpose of this study is to test the impact of Healing Circuits™; a structured mental health support model on IBD patients. The eligible study participants will be randomly divided into two groups: 1.
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
- Trial name
- NCT07013578
- Testing
- Healing Circuits™ sessions, self-directed Healing Circuits™ curriculum
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- TIDHI Innovation Inc.
Ulcerative Colitis (UC), Crohns Disease
Prospective Evaluation of the Carbon Footprint and Clinical Utility of IBUS Compared to Colonoscopy and Enterography in UC and CD
Healthcare contributes approximately 4.4% of global GHG emissions, with diagnostic imaging and endoscopic services being substantial contributors.
- Trial name
- NCT07431983
- Where
- 2 sites in India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn, Ulcerative Colitis (UC)
Research and Follow-up of the Determinants of the Progression and Complications of Inflammatory Bowel Diseases Treated or Not With Immunosuppressants.
Inflammatory Bowel Diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic, disabling conditions affecting young adults, marked by flare-ups and remissions.
- Conditions
- Crohn, Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- SUIVITHEQUE2 (NCT07172945)
- Testing
- Blood, fecal, saliva, intestinal content samples and biopsies
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ulcerative Colitis (UC), Indeterminate Colitis
CEDUR - German IBD Registry
The CEDUR registry systematically collects real-world data on inflammatory bowel disease (IBD) patients in Germany. The registry aims to assess quality of care, disease activity, treatment effectiveness, safety, and…
- Conditions
- Ulcerative Colitis (UC), Indeterminate Colitis, Crohn Disease (CD)
- Trial name
- CEDUR (NCT07319442)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- ImmunoRegister gUG
Ulcerative Colitis (UC)
FirST Lines of Biologics in pAtients With ulceRaTivE Colitis: a Randomised Controlled Trial
Ulcerative colitis (UC) is a chronic bowel disease. It causes inflammation of the rectum and sometimes the colon. This disease can also affect other parts of the body. It can be very difficult to live with on a daily basis.
- Trial name
- STARTER (NCT07576452)
- Testing
- 1: infliximab 2: filgotinib 3: ustekinumab 4: vedolizumab, 1: ustekinumab 2: vedolizumab 3: infliximab 4: filgotinib, 1: vedolizumab 2: infliximab 3: filgotinib 4: ustekinumab
- Where
- 13 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Clermont-Ferrand
Crohn's Disease, Ulcerative Colitis
A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
Crohn's Disease and Ulcerative Colitis are two types of inflammatory bowel disease (IBD), which is a serious, long-term condition in the gut (intestine) that can cause pain and swelling (inflammation) in the bowel.
- Trial name
- NCT06764615
- Testing
- Zasocitinib
- Where
- 16 sites in United States, China and 6 more
- Volunteers
- 192 people
- Sponsor
- Takeda
Ulcerative Colitis (UC), Inflammatory Bowel Disease
Fecal Microbiota Transplantation for Ulcerative Colitis Using Dai and Han Donors
This study is a randomized clinical trial evaluating fecal microbiota transplantation (FMT) for ulcerative colitis (UC) using healthy donors from two ethnic groups in Yunnan, China.
- Trial name
- NCT07814456
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Inflammatory Bowel Diseases, Crohn Disease
Validation and Clinical Impact of GLIM Criteria in Patients With Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic inflammatory conditions of the digestive tract that frequently lead to malnutrition.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative (UC), Malnutrition
- Trial name
- NCT07888023
- Volunteers
- 210 people
- Sponsor
- Assiut University
Ulcerative Colitis
Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue…
- Trial name
- HBOT-UC (NCT05987852)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 13 sites in United States
- Volunteers
- 126 people
- Sponsor
- Northwestern University
Inflammatory Bowel Disease (IBD), Crohn Disease (CD)
PROactive and Early Infliximab Monitoring and OPTimization in Inflammatory Bowel Disease
Infliximab (IFX) is a Food and Drug administration (FDA)-appoved monoclonal antibody medication targeting tumor necrosis factor (TNF) widely used in inflammatory bowel disease (IBD) to treat intestinal inflammation and improve…
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PROMPT-IBD (NCT06758024)
- Testing
- Infliximab
- Where
- Chile
- Volunteers
- 72 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Colitis, Ulcerative
Comparison of Medical RESCUE Strategies for Patients With Steroid-refractory Acute Severe Ulcerative Colitis
This study aims to examine patients with acute severe UC who are refractory to intravenous corticosteroids and determine whether a strategy of using upadacitinib first followed by infliximab in upadacitinib non-responders is…
- Trial name
- RESCUE UC (NCT06660693)
- Testing
- Upadacitinib Oral Product
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- McMaster University