Clinical trials: Ulcerative Colitis
Ulcerative Colitis
An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Participants with UC have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon.
- Trial name
- NCT05791526
- Where
- 114 sites in Japan
- Volunteers
- 308 people
- Sponsor
- AbbVie
Crohn's Disease, Ulcerative Colitis
A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)
The purpose of this study is to evaluate the safety and tolerability of long-term treatment with ontamalimab in participants with moderate to severe Ulcerative Colitis (UC) or Crohn's disease (CD)
- Trial name
- NCT03283085
- Testing
- 25 mg Ontamalimab, 75 mg Ontamalimab
- Where
- 419 sites in United States, Argentina and 35 more
- Volunteers
- 557 people
- Sponsor
- Shire
Crohn's Disease, Ulcerative Colitis
Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis
The aim of this study is to determine the tolerability and potential efficacy of dietary therapy, the Specific Carbohydrate Diet (SCD), in pediatric patients with Crohn's disease (CD) and Ulcerative Colitis (UC).
- Trial name
- SCD (NCT02213835)
- Testing
- Specific Carbohydrate diet (SCD)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- David Suskind
Colitis, Ulcerative
An Analysis of the Relationship Between the Genetic Polymorphisms of Plasminogen Activator Inhibitor-1 and Ulcerative Colitis in Chinese Patients
From January 2019 to February 2025, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT06961435
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Ulcerative Colitis
Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis
Phase 2b study to evaluate the efficacy and the safety of 3 dose-levels of ABX464, administered daily in patients with moderate to severe Ulcerative Colitis.
- Trial name
- NCT03760003
- Testing
- ABX464 100 mg, ABX464 50 mg, ABX464 25 mg
- Where
- 130 sites in United States, Austria and 15 more
- Volunteers
- 355 people
- Sponsor
- Abivax S.A.
Microbiota, Probiotic Therapy
Microbiota and Probiotic Therapy in Ulcerative Colitis Patients
This study aimed to evaluate the role of microbiota and probiotics in Egyptian patients with ulcerative colitis.
- Conditions
- Microbiota, Probiotic Therapy, Ulcerative Colitis
- Trial name
- NCT07180186
- Testing
- Mesalamine, Probiotics (Bacillus Clausii), Mesalamine and probiotics (Bacillus Clausii)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Ulcerative Colitis
Phase III Study of MLN0002 (300 mg) in the Treatment of Ulcerative Colitis
The purpose of this study is to evaluate efficacy, safety and pharmacokinetics of the vedolizumab (MLN0002) induction and maintenance therapy in Japanese participants with moderate or severe ulcerative colitis (UC).
- Trial name
- NCT02039505
- Testing
- Vedolizumab
- Where
- 59 sites in Japan
- Volunteers
- 292 people
- Sponsor
- Takeda
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Study of Inflammatory Markers (VNN1) in Crohn Disease and Ulcerative Colitis.
Inflammatory Bowel diseases (IBD) include Crohn's disease and ulcerative colitis. IBD's precise origin is unknown until now. Today, the current hypothesis of the disease pathogenesis is that IBD result from a dysregulated mucosal…
- Trial name
- VANIN (NCT02304666)
- Testing
- Colonoscopy for biopsies samples
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Inflammatory Bowel Disease (IBD)
IBD Pregnancy Registry
Data collected through the registry may be used to address a range of research questions and objectives, including but not limited to the following: Research question: Is there an increased risk of adverse maternal, fetal, or…
- Trial name
- IBD-PR (NCT06910553)
- Testing
- Non-exposed group, Exposed to IBD pharmacotherapy during pregnancy
- Where
- United States
- Volunteers
- 832 people
- Sponsor
- CorEvitas
Crohn's Disease (CD), Ulcerative Colitis (UC)
Supplementation of Vitamin D3 in Patients With Inflammatory Bowel Diseases and Hypovitaminosis D
This study aims to evaluate the effect of vitamin D3 supplementation on disease activity and quality of life in IBD patients deficient in vitamin D, and also help determine the optimal dose of vitamin D3 for them.
- Trial name
- NCT01877577
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Inflammatory Bowel Disease, Ulcerative Colitis
Assessment of Colonic Permeability by Confocal Laser Endomicroscopy
The purpose of this study is to evaluate the efficacy of confocal laser endomicroscopy in assessment of colonic permeability against conventional sugar absorption test.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Irritable Bowel Syndrome
- Trial name
- NCT00883077
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Ulcerative Colitis, Histology Remission
FIT Combining FC for Predicting MH and Histology Remission in UC
Investigaters will perform a clinical trial to asess the abilitiy of qFIT and FC on predicting UC MH and histology remission.
- Conditions
- Ulcerative Colitis, Histology Remission, Fecal Calprotetin, FIT
- Trial name
- NCT05447572
- Testing
- FIT + FC
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Ulcerative Colitis
Multistrain Probiotics Reduces UC Depression and Anxiety Scores
This pilot study aims to evaluate the effect of a 16-week duration of multistrain probiotic product (De Simone Fomulation (DSF), previously known as VSL#3 and now available as Vivomixx in EU and Visbiome in USA to reduce anxiety…
- Trial name
- NCT04006977
- Testing
- a multistrain probiotic product (DSF)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcerative Colitis
Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis
The purpose of this study is to determine whether RPC1063 is effective in the treatment of Ulcerative Colitis (UC).
- Trial name
- NCT02435992
- Testing
- RPC1063
- Where
- 372 sites in United States, Argentina and 28 more
- Volunteers
- 1,012 people
- Sponsor
- Celgene
Crohn's Disease, Ulcerative Colitis
Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.
The purpose of this study is to evaluate the incidence, prevalence, clinical characteristics and prognosis of Crohn's disease and ulcerative colitis over time in a district of Seoul, Korea.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Epidemiology, Korea
- Trial name
- NCT01731665
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Asan Medical Center
Ulcerative Colitis, Unspecified
Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis
The research aims to evaluate the efficacy and safety of that mesalazine with hydrocortisone sodium succinate for the induction of clinical remission during a 4-week double-blind treatment period in active UC (define as total…
- Trial name
- NCT03110198
- Testing
- Mesalazine, hydrocortisone sodium succinate, Mesalazine with hydrocortisone sodium succinate
- Where
- China
- Volunteers
- 528 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcerative Colitis
Controlling the Mental Health for a Better Response to Treatment in Patients With Ulcerative Colitis
The project aims to implement the Internet Of Thing (IoT) platform of the San Raffaele Hospital (OSR) with data from stress conditions perceived by the patient through the synergistic collaboration between patients…
- Trial name
- TIMAEUS (NCT06306261)
- Testing
- questionnaire
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases, Diet Modification
Fermented Food-Supplemented Diet in Ulcerative Colitis
The purpose of this study is to see how a diet that supplements fermented foods effects inflammation and quality of life in patients with mild to moderate Ulcerative Colitis (UC).
- Conditions
- Inflammatory Bowel Diseases, Diet Modification, Ulcerative Colitis
- Trial name
- NCT04401605
- Testing
- Fermented Food-supplemented Diet, Regular Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Colitis, Ulcerative
Optimization of Golimumab Treatment in Ulcerative Colitis
This is a multicenter, prospective study of dose adjustment of golimumab in patients with ulcerative colitis who will initiate golimumab treatment (naïve to anti-TNF) or after failure (or exposure) to one anti-TNF, which aims to…
- Trial name
- NCT03669029
- Testing
- Golimumab 50 mg in patients <80 kg and Golimumab 100 mg in patients >80 kg, Golimumab treatment optimization.
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital de Manises
Colitis, Ulcerative, Inflammatory Bowel Diseases
Digital Holographic Microscopy: Evaluation of Histological Disease Activity in Patients With Ulcerative Colitis
Ulcerative colitis (UC) belongs to the group of inflammatory bowel disease (IBD) and is characterized by a chronic relapsing disease course.
- Trial name
- NCT03464474
- Testing
- digital holographic microscopy
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- University Hospital Muenster