Clinical trials: Ulcerative Colitis, Unspecified
Ulcerative Colitis
Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis
The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.
- Trial name
- NCT01282905
- Where
- Belgium
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Ulcerative Colitis, Inflammatory Bowel Disease
Study Evaluating rhIL-11 in Left-Sided Ulcerative Colitis
To explore the safety of orally delivered rhIL-11 in patients with mild to moderate left-sided ulcerative colitis. To explore the effects of orally administered rhIL-11 on pharmacogenomics in blood samples and in colonic biopsy…
- Trial name
- NCT00038922
- Testing
- rhIL-11
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Inflammatory Bowel Diseases, Crohn Disease
Inflammatory Biomarkers and Disease Activity in Inflammatory Bowel Disease
This study aims to evaluate the diagnostic accuracy and clinical utility of routine blood-derived inflammatory biomarker ratios in assessing disease activity among adult patients with inflammatory bowel disease (IBD), including…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis (UC)
- Trial name
- NCT07788131
- Volunteers
- 120 people
- Sponsor
- Assiut University
Inflammatory Bowel Diseases, Periodontitis
Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)
IBD patients have a higher risk of oral diseases that affect the oral mucosa, the teeth and the tooth supporting tissues. These conditions are often associated with pain, bleeding and impaired masticatory function which may have…
- Conditions
- Inflammatory Bowel Diseases, Periodontitis, Dental Caries, Tooth Loss
- Trial name
- OQal-MICI (NCT05096897)
- Testing
- Self-administrated questionnaires
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Lille
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Pouchitis, Ulcerative Colitis
Assessment of Patients With Acute Pouchitis Treated With Antibiotics
The purpose of this study is to evaluate the reliability and responsiveness of symptoms, endoscopic, and histological items for assessing pouchitis disease activity in patients undergoing standard of care (SOC) antibiotic therapy…
- Trial name
- NCT05252273
- Testing
- Observational, No intervention
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 43 people
- Sponsor
- Alimentiv Inc.
Quality of Life, Ulcerative Colitis
Association Between Self-reported Web-based SCCAI and Health-related Quality of Life Index in UC Patients
An accurate assessment of disease activity is crucial for the treatment of patients with ulcerative colitis (UC). Recent studies have reported that the Simple Clinical Colitis Activity Index (SCCAI) correlates well with Mayo…
- Trial name
- UC (NCT04197973)
- Where
- South Korea
- Volunteers
- 225 people
- Sponsor
- YooJin Lee
Ulcerative Colitis
Etrasimod Dose-Ranging Versus Placebo as Induction Therapy Study in Adult Japanese Subjects With Moderately to Severely Active Ulcerative Colitis
The purpose of this Japan-only study is to assess the safety and efficacy of etrasimod at 2 doses in Japanese subjects with moderately to severely active ulcerative colitis (UC) when administered for 12 weeks.
- Trial name
- NCT05061446
- Testing
- Etrasimod
- Where
- 80 sites in Japan
- Volunteers
- 54 people
- Sponsor
- Pfizer
Ulcerative Colitis
(CB-01-02/04) Extension Study of Budesonide Multi-Matrix System (MMX) 6 mg in Maintenance Of Remission In Patients With Ulcerative Colitis.
Randomized, double-blind, comparative study versus placebo performed in patients from studies CB-01-02/01 (NCT00679432), CB-01-02/02 (NCT00679380), or CB-01-02/06 (NCT01100112) who achieved ulcerative colitis disease activity…
- Trial name
- NCT00801723
- Testing
- Budesonide MMX 6 mg Tablet
- Where
- 58 sites in United States, Canada
- Volunteers
- 123 people
- Sponsor
- Bausch Health Americas, Inc.
Inflamatory Bowel Disease, Crohn Disease (CD)
Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel Disease Patients
Inflammatory bowel disease patients who failed from at least two types of biologics or suffered refractory after at least twice surgery are defiened as difficult-to-treat IBD.
- Conditions
- Inflamatory Bowel Disease, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07416383
- Testing
- injection of CNK-UT009
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy, Colitis, Ulcerative
A Study of JNJ-66525433 in Healthy Participants and Participants With Ulcerative Colitis
The purpose of this study is to evaluate safety and tolerability of JNJ 66525433 compared with placebo after administration of: 1) single ascending oral doses of JNJ 66525433 administered to healthy participants (Part 1), 2)…
- Trial name
- NCT04457960
- Testing
- JNJ-66525433
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Ulcerative Colitis
Pro-active Fecal Calprotectin Monitoring PROMOTE-UC
Hypothesis: Pro-active home fecal calprotectin testing in patients with Ulcerative Colitis will allow early detection and treatment of inflammation to prevent symptomatic flares.
- Trial name
- NCT03549988
- Testing
- Fecal Calprotectin (FC) measurements with IBDocTM
- Where
- Canada
- Volunteers
- 726 people
- Sponsor
- University of British Columbia
Ulcerative Colitis
Mesalazine 4g Once Daily Versus 4g in Two Divided Doses in Active Ulcerative Colitis.
The purpose of this study was to demonstrate that mesalazine 4g orally per day once daily (QD) is non-inferior to the reference regimen, mesalazine 4g per day in two divided doses (BID) (2g x 2 per day), in patients with active…
- Trial name
- NCT00737789
- Testing
- Mesalazine slow-release granules, Mesalazine liquid enema
- Where
- 66 sites in Belgium, France and 2 more
- Volunteers
- 206 people
- Sponsor
- Ferring Pharmaceuticals
IBD, Crohn Disease
Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) are chronic diseases of the gut comprising Crohn's Disease (CD) and Ulcerative Colitis (UC). The symptoms of IBD consist of diarrhea, abdominal discomfort, weight loss, fatigue and rectal…
- Conditions
- IBD, Crohn Disease, Ulcerative Colitis
- Trial name
- VOC (NCT04827368)
- Testing
- Breath Test
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Ulcerative Colitis
Rutin Therapy Role in Reducing Ulcerative Colitis Severity
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by oxidative stress and recurring inflammation in the colon. The condition can become chronic, spread, and lead to other complications.
- Trial name
- NCT07147842
- Testing
- Rutin 500 MG, fecal calprotectin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Ulcerative Colitis
Study of Vedolizumab (MLN0002) in Patients With Moderate to Severe Ulcerative Colitis
The primary purpose of this study was to determine the effect of vedolizumab induction treatment on clinical response at 6 weeks and to determine the effect of vedolizumab maintenance treatment on clinical remission at 52 weeks.
- Trial name
- GEMINI I (NCT00783718)
- Testing
- vedolizumab
- Where
- 105 sites in United States, Canada and 1 more
- Volunteers
- 895 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Inflammatory Bowel Disease, Ulcerative Colitis
The Use of Oral Budesonide and Rectal Hydrocortisone for the Treatment of Active Ulcerative Colitis
The purpose of this study is to evaluate if the combination of oral budesonide and rectal hydrocortisone improves symptoms in patients with active ulcerative colitis.
- Trial name
- NCT00805285
- Testing
- Combination Oral Budesonide and Rectal Hydrocortisone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Maryland, Baltimore
Ulcerative Colitis
Predicting Clinical Response to Golimumab With Mucosal Barrier Dysfunction
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). UC is an ongoing disease of the colon or large intestine. Studies have shown that leakiness of the gut plays a major role in the development of UC.
- Trial name
- NCT02729233
- Testing
- patients receiving biopsies
- Sponsor
- University of Arkansas
Ulcerative Colitis, Colitis, Ulcerative
VE202 in Patients With Mild-to-Moderate Ulcerative Colitis
A Phase 2 study to evaluate the safety, efficacy, and microbiota changes of VE202 in patients with mild to moderate ulcerative colitis (UC).
- Trial name
- NCT05370885
- Testing
- VE202, Vancomycin Oral Capsule
- Where
- 49 sites in United States, Australia and 8 more
- Volunteers
- 114 people
- Sponsor
- Vedanta Biosciences, Inc.
Ulcerative Colitis
Comparison of Methotrexate vs Placebo in Corticosteroid-dependent Ulcerative Colitis
PHASE: II TYPE OF STUDY : With direct benefit DESCRIPTIVE: Multicenter, randomized, double-blind study INCLUSION CRITERIA: Steroid-dependent ulcerative colitis OBJECTIVES: To show superiority of methotrexate vs placebo in…
- Trial name
- METEOR (NCT00498589)
- Testing
- methotrexate
- Where
- 22 sites in Austria, Belgium and 4 more
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon