Clinical trials: Type2 Diabetes
Type 2 Diabetes Mellitus
A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)
This study will evaluate the effect of a single dose of sitagliptin on glucose dependent insulin secretion using a meal tolerance test (MTT) during a hyperglycemic clamp (HCG) procedure.
- Trial name
- NCT00888238
- Testing
- sitagliptin
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Metronom Continuous Glucose Monitoring System
The aim of the present study is to investigate the clinical performance of the Metronom CGM system in patients with type 1 diabetes over a period of 14 days.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabete Mellitus
- Trial name
- NCT03341026
- Testing
- Metronom CGM device
- Where
- 2 sites in Austria, Denmark
- Volunteers
- 20 people
- Sponsor
- Metronom Health
Type 2 Diabetes
Generic Drugs (Dapagliflozin and Saxagliptin) Treat Type 2 Diabetes Patients With Controlled Cancers
Use Dapagliflozin 10 mg, Saxagliptin 5 mg, Metformin 500 mg treat type 2 diabetes patients with controlled cancers
- Trial name
- GD-T2D (NCT07033585)
- Testing
- Farxiga® (dapagliflozin) + Onglyza® (saxagliptin) + Metformin Oral Mix Treat type 2 diabetes, China Import (dapagliflozin) + China Import (saxagliptin) + Metformin Oral Mix Treat type 2 diabetes
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Medical Director,, IRB Chair
Diabetes Mellitus, Type 2
Digital, Blended Lifestyle Intervention for Type 2 Diabetes Remission
410 Dutch type 2 diabetes patients will be randomized using a 5:1 ratio to intervention group versus control, to a lifestyle intervention program given via a mobile application and digital platform.
- Trial name
- IBIDEM (NCT05346614)
- Testing
- Lifestyle intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 410 people
- Sponsor
- Ancora Health B.V.
Diabetes Mellitus
COMPARISON BETWEEN TWO SUB-TYPES OF HIGH INTENSITY INTERVAL TRAINING
Recently, HIIT has been recommended by the American diabetes association for type 2 diabetes. The high-volume HIIT has been studied extensively in patients with type 2 diabetes, however, little is known about the effectiveness of…
- Trial name
- NCT05110404
- Testing
- The high-volume HIIT, The low-volume HIIT
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Cardiovascular Risk Factor, Diabetes Mellitus, Type 2
Metabolic Syndrome in Diabetic Smokers Using Cigarettes & Combustion-Free Nicotine Delivery Systems
Very little is known about the impact of combustion-free nicotine delivery systems (C-F NDS) on cardiovascular risk factors in T2DM patients who smoke.
- Trial name
- DIASMOKE (NCT04231838)
- Testing
- TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS)
- Where
- United Kingdom
- Volunteers
- 576 people
- Sponsor
- Eclat Srl.
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes
The goal of this 16-week clinical trial is to assess the health benefits of a low-fat vegan diet on insulin sensitivity and glycemic control in type 2 diabetes.
- Trial name
- NCT06106035
- Testing
- low-fat vegan diet
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Physicians Committee for Responsible Medicine
Hyperlipemia, Hypertension
A Text Message Intervention to Promote Health Behaviors in Cardiac Risk Conditions
This is a randomized pilot trial to examine the feasibility, acceptability, and preliminary efficacy of an adaptive text message intervention (TMI) to promote well-being and health behavior adherence in 60 patients with two or…
- Conditions
- Hyperlipemia, Hypertension, Type2 Diabetes
- Trial name
- NCT04382521
- Testing
- Text Message Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
Periodontitis, Adult, Prediabetes / Type 2 Diabetes
HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis
This study will evaluate whether HbA1c screening can be performed in dental care to detect elevated blood glucose in patients with advanced periodontitis and support referral to primary care.
- Trial name
- DENT-PC (NCT07688278)
- Testing
- Point-of-care HbA1c screening, Conditional standardized primary care referral
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane
Type 2 Diabetes
Effect of Meal Frequency and Timing on Insulin Dose and Clock Gene in Type 2 Diabetic Patients
This study is undertaken to explore in patients with uncontrolled T2D treated with insulin, whether a diet with large breakfast and lunch with small dinner (Bdiet) will enhance CG expression and will be more effective for weight…
- Trial name
- Bdiet-6Mdiet (NCT02709915)
- Testing
- Breakfast Diet (Bdiet), 6Meal Diet (6Mdiet
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Tel Aviv University
Overweight, Obesity
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with…
- Trial name
- NCT07589608
- Testing
- Macupatide, Eloralintide
- Where
- 40 sites in United States
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company
Diabetes, Diabetes Mellitus, Type 2
Observational Study to Evaluate Safety, Efficacy and Convenience of Using NovoMix® 30 FlexPen® in Type 2 Diabetes
This study is conducted in Asia. The aim of this observational study is to evaluate safety, efficacy and convenience in using NovoMix® 30 FlexPen® in type 2 diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00715663
- Testing
- biphasic insulin aspart 30
- Where
- Indonesia
- Volunteers
- 1,584 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus
Effect of Sitagliptin on Endothelial Progenitor Cells
Endothelial progenitor cells (EPCs) are involved in cardiovascular homeostasis, through angiogenesis and endothelial healing. Diabetic patients have a high risk of cardiovascular events and low levels of circulating EPCs.
- Trial name
- NCT00968006
- Testing
- Sitagliptin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Diabetic Nephropathies
Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy
This study was designed to assess the efficacy of adding pentoxifylline to losartan in comparison with increasing dose of losartan in type 2 diabetes patients with nephropathy.
- Trial name
- NCT03006952
- Testing
- Pentoxifylline, Losartan
- Where
- Iran
- Volunteers
- 59 people
- Sponsor
- Tehran University of Medical Sciences
Overweight, Type 2 Diabetes Mellitus
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans
This study is designed to evaluate whether epigenetic markers in overweight men with type 1 diabetes (T1D) or type 2 diabetes (T2D) can be improved with a 3 month lifestyle intervention or program focused in glycemic intervention.
- Conditions
- Overweight, Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus
- Trial name
- NCT03860558
- Testing
- Lifestyle Intervention, No Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Type 2 Diabetes
Effects of Different Types of Exercise Interventions in Patients With Type 2 Diabetes
The purposes of the study are to determine which kind of supervised exercise intervention (aerobic endurance training versus strength endurance training versus combined aerobic endurance and strength endurance training) is more…
- Trial name
- NCT01377558
- Testing
- Aerobic endurance training intervention, Strength endurance training intervention, Combined aerobic endurance and strength endurance training
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- University of Giessen
Type 2 Diabetes Mellitus (T2DM), Insulin Resistance
Therapeutic Strategies for Type 2 Diabetes Based on Lifestyle Changes: Plant-based Diet and Physical Exercise
The study evaluates the impact of a strict vegetarian diet combined with regular physical exercise and the use of probiotics on metabolic, inflammatory, and epigenetic parameters in patients with type 2 diabetes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Insulin Resistance, Inflamation, Gut Microbiomes
- Trial name
- NCT06959043
- Testing
- Probiotic Supplementation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Maria Elizabeth Rossi da Silva
Diabetes Mellitus Non-insulin-dependent
Effects of Low Power Laser Therapy on Muscle Performance Isokinetic Pre-exercise in Individuals With Diabetes Mellitus Type II
The low level laser therapy is able to improve immediately and long term (after 4 weeks of treatment, 3 days per week resulting in 12 applications of low level laser therapy) isokinetic muscle performance of the quadriceps…
- Trial name
- NCT01925443
- Testing
- Low level laser therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Metabolic Syndrome
Effect of a Low Advanced Glycation End Products (AGE) Diet in the Metabolic Syndrome
The investigators have previously demonstrated that Advanced Glycation End products (AGEs) are associated with several chronic diseases in humans and that blood AGE levels can be significantly reduced by simply changing the way…
- Trial name
- NCT01363141
- Testing
- Regular AGE Diet, Low AGE Diet
- Where
- United States
- Volunteers
- 383 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabete Type 2, Regurgitation
Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors
Treatment with semaglutide slows down gastric emptying , food remains in the stomach for a longer period of time. This slowing has important implications for anesthesia management.
- Conditions
- Diabete Type 2, Regurgitation, Pulmonary Aspiration During Anaesthetic Induction
- Trial name
- SAGUSE (NCT07506356)
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University Hospital, Geneva