Clinical trials: Type1 Diabetes Mellitus
Diabetes Mellitus, Type 1, Progression
Defining the Decline in Endogenous Insulin Secretion in Type 1 Diabetes Diagnosed After 30 Years of Age.
The study aims is to find out if people with type 1 diabetes diagnosed in later life (after age 30) have the same rapid loss of insulin secretion (measured using C-peptide) that occurs in younger adults with type 1 diabetes.
- Trial name
- DROPLeT (NCT04682457)
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Diabete Mellitus, Insulin Dependent Diabetes
Therapeutic Education Consultations With Diabetic Patients Treated With Intensified Insulin Therapy
Diabetes is a chronic condition that affects around 8% of the French population, and is associated with severe complications. Maintaining a constant blood glucose level of between 0.7 and 1.80 g/l is the day-to-day objective of…
- Trial name
- DIABETE COACH (NCT06167499)
- Testing
- Diabetes Therapeutic Education conducted by nurses
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Hopital Nord Franche-Comte
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Hypo-unawareness, Type 1 Diabetes Mellitus
Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Insulin treatment often causes the blood glucose levels to fall too low (hypoglycemia). Hypoglycemia can be associated with confusion and disorientation as well as other symptoms such as palpitations, sweating and tremors.
- Trial name
- NCT01315171
- Testing
- Medium chain triglycerides
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Type1diabetes
The Impact of a Predictive Hypoglycaemia Alert Function in Physical Activity for People With T1DM
Observational, within-subject, crossover study To assess the impact of Dexcom G6 RT-CGM with a predictive hypoglycaemia alert function on the frequency, duration and severity of hypoglycaemia occurring before, during and after…
- Trial name
- PACE (NCT04142944)
- Testing
- Dexcom G6 with alert, Dexcom G6 without alert
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 1
The Bio-Inspired Artificial Pancreas for the Home
The purpose of the study is to evaluate the safety and effectiveness of a closed-loop insulin delivery system (also known as an artificial pancreas) which is made up of three components that communicate with each other: 1.
- Trial name
- BiAP@home (NCT03740698)
- Testing
- BiAP, ABC4D
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Imperial College London
Type 1 Diabetes
Automated Structured Education Based on an App and AI in Chinese Patients With Type 1 Diabetes
In recent years, more and more attention has been paid to diabetes self-management. Glycemic control and self-management skills of patients with type 1 diabetes (T1DM) in China are poor.
- Trial name
- NCT04016987
- Testing
- Automated structured education intervention based on an app and artificial intelligence
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Second Xiangya Hospital of Central South University
Depression
Ability to Cope With Type 1 Diabetes
The purpose of this study is to learn about the relationship that exists between coping skills and blood glucose control. In addition to this, we will study the effect of type 1 diabetes on coping skills in different age groups…
- Trial name
- NCT00206362
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor College of Medicine
Type 1 Diabetes
Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes
Up to 40% of adults with type 1 diabetes have insufficient sleep which is associated with negative health consequences including poor blood glucose control and greater diabetes complications.
- Trial name
- SOPT (NCT04506151)
- Testing
- Sleep-Opt, Healthy Living
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Illinois Chicago
Type 1 Diabetes, Eating Disorder
Eating Disorders in Type 1 Diabetes: Mechanisms of Comorbidity
The purpose of the study is to investigate how people with type 1 diabetes experience and manage their diabetes, eating, and weight.
- Trial name
- NCT01513746
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Duke University
Type 1 Diabetes
Sigi Insulin Management System - A First-in-Human Study in Adults With Type 1 Diabetes
This early feasibility first-in-human study is a prospective single-arm single-center study of Sigi insulin patch pump. After a 1st day and night under medical surveillance during a hotel stay, Sigi system will be evaluated…
- Trial name
- SigiFIH (NCT05973422)
- Testing
- SIGI Insulin Management System
- Volunteers
- 10 people
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetes Mellitus, Type 1
Physical Activity Monitoring Paediatric Type 1 Diabetes
Physical activity (PA) can have positive health outcomes for children with type 1 diabetes (T1DM), yet being physically active can have unwanted side effects due to fluctuations in blood glucose (BG) level.
- Trial name
- NCT03144869
- Testing
- physical activity monitor and feedback
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Sheffield Hallam University
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes
Qingdao: Insulin Pump Follow-Up Program
The purpose of the study is to observe/ collect clinical data, subject users' feedback, and device data to better understand the real-life usage and acceptance of the 722 Pump in type 1 diabetes subjects,<18 years of age, and the…
- Trial name
- NCT02655666
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes
The purpose of this research study is to evaluate a transition preparation program designed for adolescents and young adults (AYAs) with type 1 diabetes (T1D).
- Trial name
- SHIFT2 (NCT05639088)
- Testing
- Transition preparation program, Educational materials
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Research Study to Compare a New Medicine "Fast-acting Insulin Aspart" to Another Medicine "Insulin Aspart" in Chinese People With Diabetes
Fast-acting insulin aspart (faster aspart) will be tested to see how well it works and if it is safe. The study compares 2 medicines for type 1 and type 2 diabetes - faster aspart (a new medicine) and insulin aspart (a medicine…
- Trial name
- NCT04588259
- Testing
- Faster aspart, Insulin aspart, Insulin degludec
- Where
- 40 sites in China, Hong Kong
- Volunteers
- 331 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Comparison of Two Closed-Loop Strategies for Glucose Control in Type 1 Diabetes The DREMED Trail- 2
The purpose of the study is to compare two closed-loop strategies in terms of glycemic control in Type 1 Diabetes during a camp setting. The proposed study is a four-segment feasibility study.
- Trial name
- NCT02776696
- Testing
- Advanced Hybrid Closed Loop System, Hybrid Closed Loop System
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes Mellitus, Hypoglycemia
Anti-Thymocyte Globulin, Cyclosporine, and RAD in Islet Transplantation
This study was designed to test the safety and efficacy of up to 3 pancreatic alloislet transplants in type 1 diabetic patients with hypoglycemia unawareness.
- Trial name
- NITA (NCT00286624)
- Testing
- Allogeneic Islets of Langerhans, Everolimus, anti-thymocyte globulin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Minnesota
Type 1 Diabetes
Investigation of the Impact of Different Application Volumes of Insulin Aspart in Subjects With Type 1 Diabetes
Rationale: For the development of a closed loop system, faster insulin absorption after bolus administration could help to reduce the system's delay and thus increase patient safety.
- Trial name
- NCT01399346
- Testing
- Insulin aspart
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Graz
Diabetes Mellitus, Type 1, Diabetic Nephropathy
Study of Alagebrium in Patients With Insulin-Dependent Type 1 Diabetes and Microalbuminuria
Based upon the preclinical evidence in models of diabetic nephropathy under conditions approximating both type I and II diabetes, treatment with alagebrium appears to have favorable and advantageous effects on the biochemical…
- Trial name
- NCT00557518
- Testing
- Alagebrium
- Where
- 6 sites in Australia, Denmark
- Volunteers
- 80 people
- Sponsor
- Synvista Therapeutics, Inc
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