Clinical trials: Type 2 Diabetes Mellitus (T2DM)
Type 2 Diabetes
The Impact of Food Order on Glycemic Excursions in Type 2 Diabetes Assessed by Continuous Glucose Monitoring
The purpose of this study is to explain the effect of food order/nutrient sequencing on glycemic excursions over a 2 week period, utilizing a device known as a continuous glucose monitor (CGM), for people who have been diagnosed…
- Trial name
- NCT04738799
- Testing
- Carbohydrate-Last Meal Sequence, Carbohydrate-First Meal Sequence
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Type 2 Diabetes Mellitus (T2DM)
A Telenursing Program to Support Diabetes Self-Management
This randomized controlled trial aims to develop and evaluate a telenursing-based Diabetes Self-Management Education and Support (DSMES) program with uncontrolled type 2 diabetes mellitus in Thailand.
- Trial name
- NCT07366775
- Testing
- Telenursing-Based Diabetes Self-Management Education and Support
- Where
- Thailand
- Volunteers
- 128 people
- Sponsor
- Chiang Mai University
Diabetes Mellitus Type 2
Diastolic Dysfunction and Pulmonary Hypertension in T2DM With Microalbuminuria
This is a cross-sectional observational study comparing echocardiographic markers of left ventricular diastolic function and pulmonary artery systolic pressure among healthy controls and patients with type 2 diabetes mellitus…
- Trial name
- NCT07839208
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 2 Diabetes
Mediterranean Diet vs DASH and MIND in T2DM
In our study, we aimed to comparatively evaluate the relative effects of the Mediterranean, DASH, and MIND diets on metabolic parameters in individuals with type 2 diabetes.
- Trial name
- NCT07310225
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Diabetes Mellitus, PreDiabetes
Effect of Low-Calorie Diet and Lifestyle Intervention on Reversal of T2DM
An increase in body fat, even when within the normal BMI range is one of the essential drivers of T2DM in Asian Indians. In this context, the relationship between excess hepatic fat and pancreatic fat appears to be necessary.
- Conditions
- Diabetes Mellitus, PreDiabetes, Diet Habit
- Trial name
- CURE-DM (NCT05925946)
- Testing
- CURE-DM
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Type 2 Diabetes (T2DM)
Clinical Evaluation of Salivary 1,5-Anhydroglucitol in Diabetes
The goal of this observational study is to evaluate the clinical value of salivary 1,5-anhydroglucitol (1,5-AG) and assess a novel noninvasive detection approach in individuals with and without type 2 diabetes.
- Trial name
- NCT07781683
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai 6th People's Hospital
Obesity & Overweight, Type 2 Diabetes (T2DM)
Effect of Ajwa Seed Powder on HbA1c and Body Composition in Overweight and Obese Patients With Type 2 Diabetes Mellitus
The goal of this interventional study (clinical trial) is to check if ajwa seed powder can treat type 2 diabetes mellitus in overweight and and obese patients with type 2 diabetes mellitus including both male and female of the…
- Trial name
- NCT07702097
- Testing
- Ajwa Seed powder
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Healthy Participants
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants
The purpose of this study is to measure the pharmacokinetics (PK-how the body processes the study drug) of elecoglipron in healthy participants when taken by mouth as different formulations.
- Trial name
- NCT07723833
- Testing
- Elecoglipron Reference Formulation Dose A, Elecoglipron Test formulation 1 Dose A, Elecoglipron Reference Formulation Dose B
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)
The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes.
- Trial name
- OASIS (NCT06003634)
- Testing
- Peer Coaching - Peer Participants A, Peer Coaching - Peer Participants B, Peer Coaching - Peer Participants C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 2 Diabetes Mellitus (T2DM)
Effectiveness of and Implementation Strategies for 'Disfrutando'.
Despite much research that has focused on enhancing type 2 diabetes mellitus (T2DM) health outcomes for high burden populations, more remains to be done.
- Trial name
- Disfrutando 2 (NCT07023406)
- Testing
- Disfrutando
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Missouri-Columbia
NASH - Nonalcoholic Steatohepatitis, NAFLD
Assessment of the Safety of Foralumab, an Oral Anti-CD3 Antibody, in Patients With NASH and T2DM
This is a randomized, placebo-controlled, four-arm, double-blind study. Subjects will be randomized (1:1:1:1) to receive either a daily oral placebo solution or a daily oral dose of 0.5 mg, 2.5 mg or 5.0 mg Foralumab Solution for…
- Conditions
- NASH - Nonalcoholic Steatohepatitis, NAFLD, T2DM (Type 2 Diabetes Mellitus)
- Trial name
- NCT03291249
- Testing
- Foralumab, Omeprazole 20mg
- Sponsor
- Tiziana Life Sciences LTD
Type 2 Diabetes
Renal Effects of DPP-4 Inhibitor Linagliptin in Type 2 Diabetes
The aim of this study is to detail the (mechanisms underlying the) actions of the DPP-4 inhibitor linagliptin on the renal system in patients with type 2 diabetes mellitus.
- Trial name
- RENALIS (NCT02106104)
- Testing
- Linagliptin 5 mg QD (N=24), Glimepiride 1 mg QD (N=24)
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Amsterdam UMC, location VUmc
Diabetes Mellitus, Type 2, Antioxidative Stress
Dietary Antioxidants and Thiol Disulfide Homeostasis in T2DM
This observational study was planned to determine the relationship between dietary antioxidant intake and thiol disulfide homeostasis of individuals with type 2 diabetes.
- Trial name
- NCT05688631
- Testing
- Dietary antioxidant intake
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Type 2 Diabetes Mellitus
A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus
The primary objective of this study is to determine the effect of maridebart cafraglutide relative to placebo on insulin sensitivity in participants with Type 2 Diabetes Mellitus (T2DM) treated with stable dose of metformin.
- Trial name
- NCT07160257
- Testing
- Maridebart cafraglutide
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Amgen
Type 2 Diabetes Mellitus
A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Sulfonylurea With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-253)
A study to compare safety and efficacy of sitagliptin and placebo therapy when added to stable sulfonylurea alone or in combination with metformin in participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01590771
- Testing
- Sitagliptin, Gliclazide, Glimepiride
- Volunteers
- 498 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Effect of Treatment With Finerenone on Cardio-Renal Target Organ Damage in Patients With Type 2 Diabetes.
The global prevalence of diabetes is increasing substantially. Around 40 % of patients with type 2 diabetes develop chronic kidney disease.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease Due to Type 2 Diabetes Mellitus, Cardiovascular Diseases
- Trial name
- FineCaRe (NCT07026539)
- Testing
- Finerenone (BAY 94-8862)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Diabetes Mellitus in Pregnancy, Type 2 Diabetes Mellitus (T2DM)
RCT Glargine vs NPH for Treatment of DM in Pregnancy
We are asking you to take part in this research study because you are diagnosed with pregestational Type 2 Diabetes Mellitus or Gestational Diabetes Mellitus requiring insulin therapy in pregnancy.
- Conditions
- Diabetes Mellitus in Pregnancy, Type 2 Diabetes Mellitus (T2DM), Gestational Diabetes Mellitus, Class A2
- Trial name
- NCT06619301
- Testing
- Insulin glargine, insulin NPH
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Loyola University
Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM)
Population Health Management for KPNC Members With Newly Diagnosed Diabetes: A Randomized Trial of a Proactive and Augmented Initial Care Strategy
This study is a 2-arm randomized trial of Augmented Initial Type 2 Diabetes (T2D) Care vs. Usual Initial T2D Care among adults (18-74 years) with newly diagnosed T2D who have risk factors (defined by age and diagnosis HbA1c…
- Conditions
- Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes (T2D)
- Trial name
- NCT06906653
- Testing
- Augmented Initial Type 2 Diabetes Care
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Kaiser Permanente
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia
This study aims to investigate the effects of a 12-week multimodal exercise intervention on middle-aged and older adults (aged 45~85 years) with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT07398495
- Testing
- Multimodal Exercise Program
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- yueh chu wu