Clinical trials: Tumor Microenvironment
Non Hodgkin Lymphoma
Golcadomide and Nivolumab in Patients With Non-Hodgkin Lymphoma With Refractory Disease After Chimeric Antigen T-cell Therapy
In this combined phase I/II, open label, single arm trial to study, the safety and efficacy of combination Golcadomide and nivolumab in patients with non-Hodgkin lymphoma (NHL) who have experienced refractory/residual disease, at…
- Trial name
- NCT06767956
- Testing
- GOLCADOMIDE, Nivolumab
- Sponsor
- University of Pittsburgh
To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal Carcinoma, To Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal Cancer
Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma
The purpose of this study is to evaluate the efficacy and safety of fruquintinib and pirfenidone in combination with anti-PD-1 antibody in patients with standard treatment failure of advanced or metastatic pMMR/MSS colorectal…
- Conditions
- To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal Carcinoma, To Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal Cancer, Combination of Fruquintinib and Anti-PD-1 Antibody Was Reported to Improve Patient Prognosis in Colorectal Cancer
- Trial name
- NCT06484153
- Testing
- Pirfenidone, Fruquintinib, Pembrolizumab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Myxoid Liposarcoma, Round Cell Liposarcoma
Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma
This research trial studies the immune changes following trabectedin in patients with sarcoma that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable).
- Conditions
- Myxoid Liposarcoma, Round Cell Liposarcoma, Stage III Soft Tissue Sarcoma AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7
- Trial name
- NCT03397186
- Testing
- Biopsy, Laboratory Biomarker Analysis, Trabectedin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Solid Tumor Cancer, Solid Tumor Malignancy
Pilot Study Evaluating Tumor Microenvironment Interaction in Solid Tumor Patients
This pilot study aims to compare PET/CT imaging using 68Ga-FAPI-46 to imaging results from standard MRI or CT with contrast in patients with solid tumors undergoing biologic therapy.
- Conditions
- Solid Tumor Cancer, Solid Tumor Malignancy, Cancer, Malignancy
- Trial name
- NCT06922825
- Testing
- 68Ga-FAPI-46
- Where
- United States
- Sponsor
- Eben Rosenthal
MATURE B-CELL LYMPHOIDS
Research for Resistance Factors in the Treatment of Lymphoid Hemopathy
In order to promote translational research on the molecular pathways involved in resistance to treatments for mantle cell lymphoma (MCL), the clinical haematology department of the University Hospital Center (CHU) of Nantes has…
- Trial name
- REFRACT-LyMA (NCT07385612)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Breast Cancer
Prehabilitation Exercise Program in Breast Cancer: Effects on Quality of Life and Tumor Microenvironment (PEP_BC)
To improve the health and quality of life of breast cancer (BC) patients, researchers are focusing on prehabilitation strategies like physical exercise, preparing patients both mentally and physically for clinical and surgical…
- Trial name
- PEP_BC (NCT06360809)
- Testing
- Prehabilitation exercise program
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- Institut Nacional d'Educacio Fisica de Catalunya
Pancreas Cancer
L-DOS47 Plus Doxorubicin in Advanced Pancreatic Cancer
This study will evaluate the safety and tolerability of escalating doses of L-DOS47 in combination with doxorubicin, as well as preliminary anti-tumor activity in patients with previously treated advanced pancreatic cancer.
- Trial name
- NCT04203641
- Testing
- L-DOS47, Doxorubicin
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Helix BioPharma Corporation
Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive…
- Conditions
- Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment, Radiotherapy, Adaptive Treatment
- Trial name
- PRIMO (NCT05524012)
- Testing
- Blood sample, MRI scan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Prostate Cancer
Heterogeneity of Tertiary Lymphoid Structures Predicts Distinct Malignancy and Immune Microenvironment in Prostate Cancer: a Retrospective Cohort Study
The aim of this study was to reveal the predictive value of spatial heterogeneity and maturity difference of tertiary lymphoid structure in pathological sections of prostate cancer patients for clinical features and prognosis.
- Trial name
- NCT06484127
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Lung Cancer
Decoding the Association of Imaging and Tumor Microenvironment in Lung Cancer Using Radiogenomic Approach（Radiogenomics-Lung）
This is the prospective, observational cohort study (Radiogenomics-Lung), which aims to explore the relationship between the imaging information of lung cancer patients, tumor microenvironment and the prognosis of lung cancer…
- Trial name
- NCT06500312
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Probiotic, Human Papillomavirus Infection, Pap Smear, Microbiome
The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women
A single-blind, randomized, and probiotic-treatment including adult women with vaginitis and/or HPV positive. After oral probiotics, all participants will be followd-up cervical swabs and vaginal microbiome alteration till the…
- Trial name
- NCT06001190
- Testing
- probiotic:Lactobacillus crispatus
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Solid Cancers
Monitoring of Immunological Mechanisms and Biomarkers Underlying Efficacy of Immunotherapy in Patients With Early Stage Cancer
This is a translational, multicentric, prospective cohort study aiming to identify and to monitor immunological biomarkers associated with therapeutic response to immune checkpoints blockade (ICB), and investigate the…
- Trial name
- MINER2 (NCT07427186)
- Testing
- Patients treated with immune checkpoint blockade in neo-adjuvant setting and possibly in adjuvant setting (if applicable)
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- Institut Claudius Regaud
Head and Neck Squamous Cell Carcinoma HNSCC
[68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
The trial focuses on assessing the role of [68Ga]Ga-FAPI-46 in head and neck squamous cell carcinomas (HNSCC) staging before surgery.
- Trial name
- FAPIHN (NCT06794372)
- Testing
- [68Ga]Ga-FAPI-46 PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- John O. Prior
Squamous Cell Carcinoma of Head and Neck
A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
The purpose of this study is to explore biomarker development in patients with newly diagnosed Head and neck squamous cell carcinoma (HNSCC) receiving curative therapy.
- Trial name
- HN-BIO (NCT06085781)
- Testing
- fMRI, Oral Pimonidazole
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Non-small Cell Lung Cancer, Esophageal Squamous Cell Carcinoma
Exploration of Immunodynamic Monitoring in the Population Evaluation of Neoadjuvant Chemotherapy Immunotherapy in Patients With Solid Tumors of the Chest.
Chest malignant solid tumor (mainly lung and esophageal cancer) is a common malignant tumor that seriously threatens the health of residents in China.
- Trial name
- NCT05044728
- Testing
- Anti-PD-1 antibody combined with Paclitaxel and carboplatin., Surgical treatment stage
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Advanced Solid Tumor
Less Frequent IV Dosing & Tumor Microenvironment (TME) Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy and in Combination With Pembrolizumab (ARTISTRY-3)
The study will be conducted in 2 cohorts. A single-center design for the tumor microenvironment (TME) cohort (Cohort 1), and a multicenter design for the less frequent intravenous (IV) dosing cohort (Cohort 2).
- Trial name
- ARTISTRY-3 (NCT04592653)
- Testing
- Nemvaleukin alfa, Pembrolizumab
- Where
- 6 sites in United States, Spain
- Volunteers
- 78 people
- Sponsor
- Mural Oncology, Inc
Glioma
Contribution of [18F]DPA-714 PET for Grading and Exploration of the Inflammatory Microenvironment of Glioma.
The 18-kDa translocator protein (TSPO) is a mitochondrial protein that is weakly expressed in the healthy brain. However, there is an increase in the expression of TSPO in glial tumors.
- Trial name
- INFLAGLI (NCT05672082)
- Testing
- [18F]DPA-714
- Sponsor
- Center Eugene Marquis
Gastric Cancer, Immunotherapy
The Construction of a Predictive Model for Gastric Cancer Immunotherapy Response Based on Tumor-Infiltrating Lymphocytes (TILs) and Histone H3K4me3 in the Tumor Microenvironment
Gastric cancer is one of the cancers with a high mortality rate globally, and its treatment outcomes urgently need to be improved.
- Trial name
- NCT07069842
- Testing
- Multiplex Immunofluorescence Technology, Co-Immunoprecipitation (Co-IP) Technology, Immunohistochemistry
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changzhi People's Hospital Affiliated to Changzhi Medical College
Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer
Olaptesed (NOX-A12) Alone and in Combination With Pembrolizumab in Colorectal and Pancreatic Cancer
The purpose of this study is to show that the type, number and/or distribution of tumor metastases infiltrating immune cells such as cytotoxic T cells and/or the cytokine signature in the tumor metastases can be modulated by…
- Trial name
- Keynote-559 (NCT03168139)
- Testing
- Olaptesed pegol - Monotherapy, Olaptesed pegol + Pembrolizumab - Combination Therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- TME Pharma AG
Stomach Cancer
The Effect of Immunological Heterogeneity of Tumor Microenvironment in the Prognosis of Gastric Cancer
The purpose of this study is to explore the effect of immunological heterogeneity of tumor microenvironment in the short-term outcome and long-term outcome of patients with gastric cancer.
- Trial name
- NCT04819958
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fujian Medical University