Clinical trials: Tuberculosis Infection
Tuberculous Meningitis
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC)…
- Trial name
- NCT05383742
- Testing
- Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD)
- Where
- 18 sites in Brazil, India and 10 more
- Volunteers
- 330 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Aerosol BCG Challenge Study in Historically BCG-vaccinated Volunteers
The purpose of this study is to evaluate the human clinical response to BCG challenge in historically BCG-vaccinated healthy adult volunteers. It will involve 12 participants in a controlled dose escalation.
- Trial name
- NCT04777721
- Testing
- BCG Danish
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis Infection
Development of Automated Molecular Diagnostic Platform for Tuberculosis Diagnosis (New Assay TB)
It is intended for patients who have been admitted to the outpatient or emergency room or are hospitalized For patients who diagnose pulmonary tuberculosis or extrapulmonary tuberculosis using Xpert TB/RIF, additionally, diagnose…
- Trial name
- New Assay TB (NCT04988984)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Advanced Cancer
Latent Tuberculosis Infection in Cancer Patients
Primary Objective: 1. To evaluate the performance of the new T-SPOT.TB test and the conventional TST for screening of Latent Tuberculosis infections in patients with cancer and those undergoing Hematopoietic Stem Cell Transplant.
- Trial name
- NCT00507754
- Testing
- T-SPOT TB test
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Tuberculosis
Pharmacokinetic and Therapeutic Adaptation of Linezolid in the Treatment of Multi-Resistant Tuberculosis
Linezolid, primary treatment for MDR-TB combination therapy anti. Until it is the dose of 600 mg x1 / day, rather sensible for most patients is more, which was unanimous.
- Trial name
- LINEZOLIDE (NCT02778828)
- Testing
- Linezolid
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Tuberculosis
Diagnosing of Acute Tuberculosis
Sweat proteins are analysed to investigate differences in protein markers in patients with acute tuberculosis and other pulmonary diseases (pneumonia, Bronchitis, chronic obstructive pulmonary disease (COPD)) and healthy…
- Trial name
- SwEaTB (NCT03667742)
- Testing
- analysis of sweat and serum samples for protein markers
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people
- Sponsor
- University Hospital, Basel, Switzerland
Lymphadenopathy, Lymphnode Metastasis
Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes
Lymph nodes are one of the most important components of the human immune system, and superficial lymph node enlargement lacks specificity.
- Conditions
- Lymphadenopathy, Lymphnode Metastasis, Lymphoma, Lymphatic Tuberculosis
- Trial name
- NCT07155954
- Testing
- SRUS imaging of the lymph nodes before surgery or biopsy
- Where
- China
- Volunteers
- 779 people
- Sponsor
- Peking University Third Hospital
Tuberculosis
A Phase I Study of the Safety and Immunogenicity of a Recombinant MVA Vaccine Encoding a Secreted Antigen From M. Tuberculosis, Antigen 85A, Delivered Intradermally by a Needle Injection in Healthy Volunteers Who Have Previously Received BCG
This is a phase I study to examine the safety and immunogenicity of MVA85A delivered intradermally into the deltoid region in volunteers who have recieved BCG in the past 20 years.
- Trial name
- NCT00427830
- Testing
- MVA85A
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Safety and Efficacy of High Dose Rifampicin in Tuberculosis (TB)-HIV Co-infected Patients on Efavirenz- or Dolutegravir-based Antiretroviral Therapy
Higher doses of rifampicin has been associated with a faster drop in bacterial load over time, and shorter treatment regimens with high dose rifampicin are being proposed.
- Trial name
- SAEFRIF (NCT03982277)
- Testing
- Rifampin 300 Mg Oral Capsule
- Where
- Uganda
- Volunteers
- 130 people
- Sponsor
- Makerere University
Latent Tuberculosis, HIV
Quantiferon Gold Test for Detecting Tuberculosis (TB) Infection in HIV/AIDS Patients in South Africa
The purpose of this study is to use a cluster randomized trial to compare the effectiveness of linking the Quantiferon-gold in-tube test (QGIT) with routine CD4 testing to the routine use of the tuberculin skin test (TST), the…
- Trial name
- NCT02119130
- Testing
- QGIT
- Where
- 14 sites in South Africa
- Volunteers
- 3,506 people
- Sponsor
- Johns Hopkins University
Tuberculosis, HIV
Dolutegravir/Lamivudine Dual Therapy for ART-naïve People With HIV and TB Receiving Rifampin-based TB Treatment
This will be a Phase IIIb Clinical Trial, an international multicenter, randomized, three-arm, non-comparative trial of efficacy, safety, and tolerability of the dual therapy regimen dolutegravir plus lamivudine either twice…
- Trial name
- DOVETAIL (NCT06497465)
- Testing
- Dolutegravir 50mg Tab, Dolutegravir/Lamivudine 50 MG-300mg Oral Tablet [DOVATO], Dolutegravir plus Tenofovir disoproxil fumarate (TDF)/ lamivudine (3TC)
- Where
- 5 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Tuberculosis, Pulmonary
Study on the Management Model of "Home Treatment" for Tuberculosis Patients
This project aims to standardize the management of "home treatment" for tuberculosis patients, improve the compliance of patients with treatment, reduce the risk of transmission, and study the establishment of "home treatment"…
- Trial name
- NCT03967353
- Testing
- New management mode intervention
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Beijing Chest Hospital
Tuberculosis
Treatment of Latent TB Infection for Jailed Persons
The purpose of this study is to determine whether an alternative drug, (rifampin) given daily, is better at treating tuberculosis (TB) and more tolerable than the usual drug treatment, isoniazid (INH).
- Trial name
- NCT00128206
- Testing
- Isoniazid, Rifampin
- Where
- United States
- Volunteers
- 364 people
- Sponsor
- University of California, San Francisco
Tuberculosis, Pulmonary, Interferon-gamma Release Tests
IGRA and Mantoux Response in Children With Suspected Latent or Active TB Infection
The aim of this project is to analyze the potential contribution of IGRA test QuantiFERON-TB Gold In Tube test (QTF-GIT, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent)…
- Conditions
- Tuberculosis, Pulmonary, Interferon-gamma Release Tests, Tuberculin Test
- Trial name
- TBTubercolar (NCT02653404)
- Testing
- IGRA test (QTF-GIT)
- Where
- 3 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Siena
Tuberculosis Infection, Chronic Obstructive Pulmonary Disease
COPD Co-infection With Tuberculosis on Th17 Cell Differentiation
This project will observe and follow up the changes of pulmonary function and CT in patients with smoking combined with pulmonary tuberculosis, and measure the ratio of Th1 cells, Th17 cells, macrophages and neutrophils and the…
- Trial name
- NCT04966052
- Testing
- No intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
HIV and Tuberculosis Co-infection
Nutritional Support for HIV-Tuberculosis Co-infected Adults in Senegal, West Africa
Food insecurity can contribute to poor adherence to both tuberculosis treatment and antiretroviral therapy (ART). Interventions that target food insecurity have the potential to improve treatment adherence and decrease mortality.
- Trial name
- NCT03711721
- Testing
- Food basket, Ready-to-Use Therapeutic Food
- Volunteers
- 26 people
- Sponsor
- University of Washington
Tuberculosis, Extrapulmonary Tuberculosis
Biomarker Analysis for Diagnosing and Treatment Monitoring in Extrapulmonary Tuberculosis Patients in Nairobi, Kenya
Tuberculosis (TB) remains a global health threat with high incidence, especially in Africa. The proportion of extrapulmonary TB (EPTB) can escalate up to 36% in areas with a high HIV prevalence.
- Conditions
- Tuberculosis, Extrapulmonary Tuberculosis, Mycobacterium Tuberculosis
- Trial name
- BioTube (NCT07901387)
- Where
- 2 sites in Kenya
- Volunteers
- 700 people
- Sponsor
- Nagasaki University
Rifampicin-Resistant Pulmonary Tuberculosis Patients
Drug-Drug Interaction and Food Effect of Sudapyridine(WX-081) With Itraconazole and Rifampin in Healthy Chinese Adults
The goal of this clinical trial is to learn how Sudapyridine (WX-081) tablets interact with other drugs and how food intake affects its pharmacokinetics in healthy Chinese adults.
- Trial name
- WX081-DDI (NCT06701136)
- Testing
- Sudapyridine, Itraconazole, Rifampin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiatan Pharmatech Co., Ltd
HIV Infections, Tuberculosis
Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings
Tuberculosis (TB), a bacterial infection common in HIV infected people, is a major problem in developing countries. The purpose of this study is to test the effectiveness of a combined treatment strategy using directly observed…
- Trial name
- NCT00091936
- Testing
- Didanosine, Efavirenz, Lamivudine
- Where
- 2 sites in South Africa
- Volunteers
- 592 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis Infection
1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam
Introduction: Tuberculosis (TB) infection is a key driver of the TB pandemic, with over 10.6 million people fell ill with TB disease in 2022.
- Trial name
- NCT06191692
- Testing
- Isoniazid, Rifapentine, Rifampicin
- Where
- 2 sites in Vietnam
- Sponsor
- Freundeskreis Für Internationale Tuberkulosehilfe e.V