Clinical trials: Tuberculosis, completed
Pulmonary Tuberculosis
Safety, Efficacy and Pharmacokinetics of OPC-67683 in Patients With Pulmonary Tuberculosis
The purpose of this trial is to evaluate the safety, efficacy and pharmacokinetics of 100mg, 200mg , 300mg and 400mg once daily of OPC-67683, administered orally for 14 consecutive days, in patients with uncomplicated…
- Trial name
- NCT00401271
- Testing
- OPC-67683, Rifafour e-275
- Where
- 3 sites in South Africa
- Volunteers
- 54 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Tuberculosis, Meningeal
Adjunctive Linezolid for the Treatment of Tuberculous Meningitis
This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at Masaka Regional Referral Hospital…
- Trial name
- ALTER (NCT04021121)
- Testing
- LZD, High dose RIF, Standard dose RIF
- Where
- Uganda
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Tuberculosis, Tuberculosis, Pulmonary
Study to Evaluate Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects
A Phase 1, Partially-Blinded, Placebo-Controlled, Randomized, Multiple Ascending Dose Study to Include A Single Dose Food-Effect Study to Evaluate the Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects
- Trial name
- NCT04865536
- Testing
- TBI-223 1800 mg, TBI-223 2400mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Sporotrichosis, Chromomycosis
A Study on Rare Dermatological Infections Conducted at Three Major Reference Hospitals in Costa Rica.
In Costa Rica there are some descriptive studies of some of these rare infectious diseases (sporotrichosis, chromomycosis and mycetomas); however, there are no recent published reports.
- Conditions
- Sporotrichosis, Chromomycosis, Actinomycosis, Nocardiosis
- Trial name
- NCT06523998
- Where
- 3 sites in Costa Rica
- Volunteers
- 95 people
- Sponsor
- Caja Costarricense de Seguro Social
Tuberculosis
Phase I Clinical Trial to Evaluate the Safety of Recombinant Mycobacterium Tuberculosis Fusion Protein (EEC) in Healthy Adults Aged 18-65 and Patients With Pulmonary Tuberculosis
The study is to enroll 60 participants aged 18-65 years old, including 30 healthy subjects and 30 tuberculosis patients. Low-dose (2.5 μg/ml), medium-dose (5 μg/ml), and high-dose (10 μg/ml) studies will be conducted separately…
- Trial name
- NCT06224608
- Testing
- Recombinant Mycobacterium Tuberculosis Fusion Protein (EEC)
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chengdu CoenBiotech Co., Ltd
HIV Infections, Tuberculosis
Efficacy of Tenofovir-Emtricitabine and Efavirenz in HIV Infected Patients With Tuberculosis (ANRS129)
Successful therapy of both tuberculosis and HIV disease share similar problems: pill burden, drug interaction, adherence challenge and toxicity.
- Trial name
- NCT00115609
- Testing
- efavirenz, tenofovir DF, emtricitabine
- Where
- France
- Volunteers
- 70 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Vitamin D Deficiency, Tuberculosis
Role of Vitamin D in Innate Immunity to Tuberculosis
The investigators proposed a pilot study preparatory to developing a randomized trial of vitamin D for the prevention of TB infection. The specific aims are presented below: 1.
- Trial name
- NCT01244204
- Testing
- Vitamin D
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Moderate Hepatic Impairment
A Study of TMC207 in Patients With Moderately Impaired Hepatic Function
The purpose of this study is to assess the pharmacokinetics (what the body does to the medication), safety and tolerability of TMC207 and its N-monodesmethyl metabolite (M2) in healthy participants and in patients with moderate…
- Trial name
- NCT01012284
- Testing
- TMC207
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Tuberculosis, Pleural Effusion
Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion
Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis (EPTB) seen in clinical practice after tuberculosis (TB) lymphadenitis.
- Trial name
- NCT01560078
- Where
- India
- Volunteers
- 360 people
- Sponsor
- All India Institute of Medical Sciences
Tuberculosis
Phenotyping of High Dose Rifampicin
Higher doses of rifampicin as a means of more efficient use of this pivotal TB drug has shown promising results and might become standard in future.
- Trial name
- PHENORIF (NCT04525235)
- Testing
- phenotyping cocktail, rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
HIV Infection, MDR-TB
HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes
This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran.
- Trial name
- NCT06671808
- Testing
- Examination of HIV Infection in Patients with Multi-Drug Resistant Tuberculosis (MDR-TB)
- Where
- Iran
- Volunteers
- 222,128 people
- Sponsor
- Zahedan University of Medical Sciences
Latent Tuberculosis Infection, Tuberculosis
Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis
This is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease.
- Trial name
- NCT01622140
- Where
- 10 sites in United States
- Volunteers
- 21,334 people
- Sponsor
- Centers for Disease Control and Prevention
Tuberculous Pleurisy
Drainage of Tuberculous Pleural Effusions
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to…
- Trial name
- NCT00524147
- Testing
- Pigtail drainage
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Taipei Medical University Hospital
Diagnosis of Tuberculosis in People Living With HIV
FujiLAM Prospective Evaluation Trial
This is a prospective, multicentre cohort study in which the accuracy and the diagnostic yield of the FujiLAM test will be assessed using a microbiological reference standard, an extended microbiological reference standard and a…
- Trial name
- NCT04089423
- Testing
- Fujifilm SILVAMP TB LAM
- Where
- 7 sites in Malawi, South Africa and 5 more
- Volunteers
- 1,731 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
MDR-TB
A Study of Ultrashort PRS Regimen V in the Treatment of MDR-TB
This is an exploratory, prospective, randomized, active control, and open label clinical trial to evaluate the efficacy and safety of 6-9 months treatment with the ultrashort PRS Regimen V.
- Trial name
- NCT05278988
- Testing
- PRS Regimen V, MDR-TB Treatment Regimen(WHO)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
HIV Infection, Tuberculosis
Screening for Tuberculosis in HIV-infected Patients Eligible for Antiretroviral Treatment
Background: Increased access to antiretroviral therapy (ART) in Africa will require decentralization to primary health care. For this purpose, adapted methods for management of patients co-infected with tuberculosis (TB) and HIV…
- Trial name
- NCT01433796
- Where
- 5 sites in Ethiopia
- Volunteers
- 812 people
- Sponsor
- Lund University
Chronic Kidney Disease, Tuberculosis
A Pilot Study for Pharmacokinetic Parameter of Colchicine in Patient Taking Rifampin
The purpose of this study is to examine the colchicine concentration before and after the administration of rifampicin.
- Trial name
- NCT01932268
- Testing
- Rifampicin
- Volunteers
- 2 people
- Sponsor
- Seoul National University Hospital
Mycobacterium Tuberculosis
A Cluster-Randomized Trial of DOTS vs DOTS Plus Active Case Finding
The purpose of the study is to see if one plan for identifying and treating tuberculosis (TB) works better than another in reducing new cases of TB.
- Trial name
- NCT00414882
- Where
- Brazil
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
First Time in Human (FTIH) Safety and Pharmacokinetics (PK) Study of GSK3036656 in Healthy Subjects
GSK3036656 is being developed by GSK for the treatment of tuberculosis (TB). This is the FTIH study for GSK3036656 to evaluate the safety, tolerability and PK of single ascending and repeat oral doses of GSK3036656 in healthy…
- Trial name
- NCT03075410
- Testing
- GSK3036656
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Tuberculosis
Using Biomarkers to Predict TB Treatment Duration
Background: Tuberculosis (TB) is a bacterial lung infection. Typical treatment using anti-TB drugs lasts about 6 months. Some people with less severe TB might not need to take the drugs that long.
- Trial name
- NCT02821832
- Testing
- Saliva collection, Urine collection, Sputum collection
- Where
- South Africa
- Volunteers
- 946 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)