Clinical trials: Troponin
Cyanosis
Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery
This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.
- Trial name
- NCT01311310
- Testing
- RIPC (remote ischemic preconditioning)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Cancer, Immune Checkpoint Inhibitor
Troponin to Detect Major Cardiovasculaire Advserse Events on Immune Checkpoint Inhibitors
Recent guidelines suggest the use of troponin to detect immnune related cardiovascular advserse events in patients treated by immune checkpoint inhibitors for cancer.
- Conditions
- Cancer, Immune Checkpoint Inhibitor, Cardiovascular Biomarkers
- Trial name
- TILT (NCT06007274)
- Testing
- No intervention
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut Mutualiste Montsouris
Acute Myocardial Infarction (AMI)
SpinChip Hs-cTnI Multisite Precision
During a heart attack, the protein troponin I is released from the heart muscle into the bloodstream. Measurements of cardiac troponin in blood are used as an aid in the diagnosis of heart attack.
- Trial name
- HEAT-1 (NCT06851013)
- Testing
- SpinChip hs-cTnI
- Where
- 3 sites in Norway
- Volunteers
- 37 people
- Sponsor
- SpinChip Diagnostics ASA
Hip Fracture
Troponin Elevation in the Elderly Patient With Hip Fracture
Elevated troponin is powerful and independent adverse prognostic marker in patient with ACS. However, non specific (non cardiac) troponin elevation is a common finding among hospitalized patients and worse prognosis too.
- Trial name
- NCT00647309
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Myocardial Infarction, Myocardial Injury
Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality
The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin.
- Trial name
- DIGNITY (NCT03630237)
- Where
- United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Coronary Artery Disease, Myocardial Infarction
Mi-RNAs and Specificity of Hs-TnT in Symptomatic ED Patients
Biomarkers play a key role in the diagnostic workup of patients presenting to an emergency department (ED). European and American guidelines recommend cardiac Troponin (T or I) as the biomarker gold standard for the diagnosis of…
- Trial name
- NCT02116153
- Sponsor
- University Hospital Heidelberg
Diagnoses Disease
Reference Interval Validation of High-Sensitivity Cardiac Troponin T Assay in Thai Population
The investigators aimed to study the cut-off of high sensitivity troponin T using SYSMEX HLSCL Machine in Thai population at percentile 99.
- Trial name
- NCT03968016
- Testing
- SYSMEX HLSCL
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Evaluation of Troponin I Levels
Prospective Analysis and Comparison of Stress Echo to Real-Time Myocardial Contrast Stress Echo
The purpose of this study is to prospectively analyze and compare conventional stress echocardiograms and real-time myocardial contrast stress echocardiograms; and to determine the effect of contrast agents used during real-time…
- Trial name
- NCT00575549
- Testing
- Dobutamine: Perflutren Lipid Microsphere
- Where
- United States
- Sponsor
- University of Nebraska
Acute Chest Pain, NSTEMI - Non-ST Segment Elevation MI
Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department.
- Trial name
- PRESC1SE-MI (NCT05649384)
- Testing
- European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm, European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm
- Where
- 20 sites in United States, Australia and 9 more
- Volunteers
- 64,374 people
- Sponsor
- University Hospital, Basel, Switzerland
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
The purpose of this study is to determine possible alterations in cardiac function in patients with Rheumatoid Arthritis and Ankylosing Spondylitis under anti-TNF therapy, without clinical heart disfunction at baseline, using…
- Trial name
- NCT01072058
- Testing
- TNF blockers (infliximab, adalimumab, etanercept)
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Extremity Orthopedic Surgery
Perioperative Cardiac Troponin Levels in Healthy Adults
This study will determine the extent of high-sensitivity cardiac troponin (hs-cTn) release in patients without cardiac risk factors undergoing extremity orthopedic surgery.
- Trial name
- NCT02394288
- Testing
- Extremity orthopedic or trauma surgery
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Myocardial Infarction, Sex Differences
Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women
The project is focussed on evaluating the impact of using a female-specific threshold in the diagnosis of myocardial infarction. This female threshold is lower than the overall hs-cTn threshold currently in use.
- Conditions
- Myocardial Infarction, Sex Differences, High Sensitivity Troponin
- Trial name
- CODE-MI (NCT03819894)
- Testing
- Introduction of a lower female hs-cTn threshold
- Where
- Canada
- Volunteers
- 24,000 people
- Sponsor
- BC Centre for Improved Cardiovascular Health
Myocardial Injury
Study of Ticagrelor Versus Aspirin Treatment in Patients With Myocardial Injury Post Major Non-cardiac Surgery
The purpose of this pilot study is to establish the rate of cardiovascular events in patients with elevated troponins levels after major, non-cardiac surgery and to evaluate the efficacy and safety of FDA approved study drug…
- Trial name
- INTREPID (NCT02291419)
- Testing
- ticagrelor, aspirin
- Where
- 24 sites in United States
- Volunteers
- 6 people
- Sponsor
- The Cleveland Clinic
Acute Coronary Syndrome
A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.
One proposed strategy is the stratification of troponin-negative patients with biomarker testing at presentation to facilitate the clinically-appropriate rapid discharge from the emergency department of patients who present with…
- Trial name
- NCT03218007
- Testing
- blood samples
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Perioperative Myocardial Injury
Anesthesia Induced Myocardial Injury in Non-cardiac Surgery (AIMY)
Myocardial injury during non-cardiac surgery (PMI) affects up to 16% of high-risk patients and represents a significant burden on healthcare systems.
- Trial name
- AIMY (NCT07179029)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Dengue Shock Syndrome, Children, Only
NT-proBNP and Troponin I in Dengue Children
To discribe concentration of NT-proBNP and Troponin I in Dengue hemorrhagic shock children, in correlation between concentration of NT-proBNP and troponin I with total fluid admission, respiratory support, using inotrope and…
- Trial name
- NCT04837430
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- Le Phuoc Truyen
Myocardial Injury, Surgery--Complications
Myocardial Injury Following Non-cardiac Surgery
It is estimated that > 200 million patients in the world undergo surgery each year of which approximately 10 million will suffer from a myocardial injury in the perioperative period.
- Trial name
- EMINENT (NCT03317561)
- Where
- Sweden
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Coronary Artery Disease
TREAT Study - Improving the Interpretation of Troponin Concentrations Following Exercise and Their Clinical Significance
The goal of this observational study is to learn about cardiac biomarker release following exercise in amateur athletes. The main questions it aims to answer are: Question 1: What are the reference values for exercise-induced…
- Trial name
- TREAT (NCT06295081)
- Testing
- Exercise exposure
- Where
- Netherlands
- Volunteers
- 1,015 people
- Sponsor
- Radboud University Medical Center
Traumatic Brain Injury
Ischemia Modified Albumin in Traumatic Brain Injury
In the current study the investigators intend to evaluate the role of Ischemia modified albumin (IMA) in the prediction of poor outcome in patients with traumatic brain injury (TBI).
- Trial name
- NCT03637101
- Testing
- Ischemia modified albumin (IMA)
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Kasr El Aini Hospital
Acute Coronary Syndrome
Assessment of Biomarkers for Diagnosis in Geriatric Patients
Elderly patients are often admitted to hospital because of chest pain that is atypical for angina pectoris. In case of inconclusive electrocardiograms, determination of troponin is important for the diagnosis of an acute coronary…
- Trial name
- BOSCH1 (NCT01370395)
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- University of Erlangen-Nürnberg Medical School