Clinical trials: Trigeminal Autonomic Cephalalgia
Chronic Cluster Headache
A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH)
The main goal of this trial is to inform about long-term safety and tolerability of eptinezumab in participants with chronic cluster headache.
- Trial name
- CHRONICLE (NCT05064397)
- Testing
- Eptinezumab
- Where
- 31 sites in United States, Denmark and 7 more
- Volunteers
- 131 people
- Sponsor
- H. Lundbeck A/S
Cluster Headache
Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache
Multi-center, prospective, double-blind, randomized, sham-controlled pivotal study of non-invasive vagus nerve stimulation with the GammaCore® device for the acute treatment of cluster headache.
- Trial name
- CH (NCT01792817)
- Testing
- GammaCore
- Where
- 20 sites in United States
- Volunteers
- 150 people
- Sponsor
- ElectroCore INC
Cluster Headache, Trigeminal Autonomic Cephalalgias
Efficacy of Erenumab in Chronic Cluster Headache
The main purpose of this study is to evaluate the efficacy of erenumab in participants with chronic cluster headache.
- Conditions
- Cluster Headache, Trigeminal Autonomic Cephalalgias, Headache Disorders, Primary, Brain Disease
- Trial name
- CHERUB01 (NCT04970355)
- Testing
- Erenumab
- Where
- 11 sites in Germany
- Volunteers
- 101 people
- Sponsor
- Charite University, Berlin, Germany
Migraine, Cluster Headache
Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache
This is an observational, longitudinal cohort pilot study measuring physiological signals through wearable sensors combined with machine learning algorithms to detect behaviour, stress and headaches in patients with migraine and…
- Trial name
- COPIMAC (NCT04949204)
- Testing
- Wearable sensor detection
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Ghent
Chronic Cluster Headache
Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks
The goal of this clinical trial is to evaluate the efficacy of low sodium oxybate (LXB) (brand name Xywav) in the treatment of (nocturnal) cluster headache attacks in subjects with chronic cluster headache.
- Trial name
- SUNCET (NCT06950281)
- Testing
- Low Sodium Oxybate
- Volunteers
- 52 people
- Sponsor
- Leiden University Medical Center
Cluster Headache
Atrioventricular Block and Cluster Headache (SEVA)
Verapamil is a calcium channel blocker widely used to treat cardiovascular diseases however it is also the first line treatment in the prevention of cluster headaches.
- Trial name
- SEVA (NCT04406259)
- Testing
- Verapamil
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cluster Headache, Episodic
Exploration of Cluster Headache in a PET-MRI Study
Observational study in PET-MRI using the 5-HT1A agonist PET radiotracer [18F]F13640.
- Trial name
- F13640-AVF (NCT05084469)
- Testing
- PET-MRI in pain-free remission period
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Chronic Cluster Headache
A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.
The purpose of this clinical trial is to evaluate the safety and effectiveness of the Occipital Nerve Stimulation System (ONSS) in treating chronic cluster headache in adults.
- Trial name
- ONFIELD (NCT07677137)
- Testing
- Occipital Nerve Stimulation System
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Man and Science, SA
Migraine Disorders
Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan
This study will be conducted to collect cases treated by self-injection of sumatriptan 3mg kit product for the treatment of migraine or cluster headache attacks in clinical settings, to demonstrate the efficacy, and to examine…
- Trial name
- NCT00356603
- Testing
- Sumatriptan Succinate
- Where
- 4 sites in Japan
- Volunteers
- 75 people
- Sponsor
- GlaxoSmithKline
Chronic Cluster Headache
Response to Combined Trigeminal and Occipital Nerve Stimulation for the Preventive Treatment in Chronic Cluster Headache
This is a limited open-label study being performed at two centers in the Netherlands. All participants will receive the same treatment, and both the patients and doctors will know what that treatment is.
- Trial name
- SalviaBio (NCT07113470)
- Testing
- The Salvia PRIMUS implantable neurostimulator System
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Salvia BioElectronics
Cluster Headache
Efficacy and Safety of Zolmitriptan by Sublingual Administration
The purpose is to evaluate the effectiveness and safety profile of zolmitriptan by Sublingual administration for the acute treatment of Cluster headache.
- Trial name
- NCT03377257
- Testing
- zolmitriptan by sublingual administration, zolmitriptan by oral
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Headache Disorders, Primary, Migraine
China HeadAche DIsorders RegiStry
It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected.
- Conditions
- Headache Disorders, Primary, Migraine, New Daily Persistent Headache, Medication Overuse Headache
- Trial name
- CHAIRS (NCT05334927)
- Testing
- Medicine Overuse Headache/New Daily Persistent Headache, Episodic Migraine and Chronic Migraine, Patients with other types of primary headache
- Where
- 61 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
Cluster Headache, Trigeminal Autonomic Cephalgia
Detection of Local Field Potentials in the Ventral Tegmental Area of the Midbrain in Chronic Cluster Headache Patients
The physiopathology of trigeminal-autonomic cephalalgia, and more particularly of cluster headache (CH) is still partially unknown.
- Trial name
- DETECT (NCT05857098)
- Testing
- Local Field potential recording
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cluster Headache
An Open Label Study Using Consecutive Intravenous Depacon With Oral Depakote ER for the Treatment of Cluster Headaches.
The purpose of this study is to collect and evaluate information on the use of Depakote Extended Release (ER) and Depacon Intravenous (IV) in patients with cluster headaches.
- Trial name
- NCT00203242
- Testing
- Depacon IV and Depakote ER
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Thomas Jefferson University
Cluster Headache
A Close Examination of Patient Experiences in Cluster Headache Clinical Research
Historically, participation in clinical studies is highly skewed towards particular demographic groups of people. This research will invite several participants to gather a wide range of information on clinical trial experiences…
- Trial name
- NCT05978258
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Episodic Cluster Headache
Civamide Nasal Solution for Cluster Headache
The purpose of this study is to evaluate the safety and efficacy of intranasally administered civamide nasal solution in the prevention of cluster headaches during an episodic cluster headache period.
- Trial name
- ECH (NCT01341548)
- Testing
- Civamide nasal solution 0.01%
- Volunteers
- 180 people
- Sponsor
- Winston Laboratories
Cluster Headache
Cluster Headache Treatment Survey
The objective of this study is to survey patients with cluster headache about treatment effectiveness and their views on treatments. Participants will complete one brief questionnaire online.
- Trial name
- NCT06011811
- Where
- United States
- Volunteers
- 2,487 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cluster Headache
Cluster Headache, Addictions and Vascular Function
Cluster headache (CH) is one of the most painful primitive headaches. Developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions.
- Trial name
- CHAD (NCT02640105)
- Testing
- Neurological clinical examination, Psychological clinical examination, Questionnaires
- Where
- France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Bordeaux
Primary Headache Disorders
A Prospective Observational Registry of Primary Headache Patients Treated With Ausanil
This study is an observational study with the primary objective to assess the safety and tolerability of Ausanil in the treatment of primary headache disorders.
- Trial name
- NCT02392273
- Testing
- Ausanil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VR1 Corporation
Cluster Headache
Cluster Headache Treatment With Rimegepant
The purpose of this research is to explore the efficacy of rimegepant as a preventative therapy for cluster headache.
- Trial name
- NCT05264714
- Testing
- Rimegepant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic