Clinical trials: Trigeminal Autonomic Cephalalgia
Episodic Cluster Headache
A Study Of Galcanezumab In Participants With Episodic Cluster Headache
The main purpose of this study is to evaluate the efficacy and safety of the study drug known as Galcanezumab in participants with episodic cluster headaches.
- Trial name
- NCT02397473
- Testing
- Galcanezumab
- Where
- 47 sites in United States, Belgium and 10 more
- Volunteers
- 109 people
- Sponsor
- Eli Lilly and Company
Cluster Headache
Pathway CH S&E Registry
Monitor the safety and performance of the Pulsante Microstimulator System.
- Trial name
- SER (NCT02440776)
- Where
- 9 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people
- Sponsor
- Autonomic Technologies, Inc.
Chronic Cluster Headache
Sphenopalatine Ganglion Stimulation for the Treatment of Chronic Cluster Headache
The primary objective of the study is to demonstrate the safety and efficacy of SPG stimulation with the ATI Neurostimulation System when used to treat acute cluster attacks in chronic cluster headache patients.
- Trial name
- NCT02168764
- Testing
- ATI Neurostimulation System
- Where
- 24 sites in United States
- Volunteers
- 120 people
- Sponsor
- Autonomic Technologies, Inc.
Chronic Cluster Headache
Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache
The purpose of the proposed clinical study is to evaluate the use of an implanted Neurostimulator to provide Sphenopalatine Ganglion (SPG) stimulation for the management of the pain associated with cluster headaches.
- Trial name
- NCT01255813
- Testing
- Stimulation (Sub-perception), Stimulation (Full), Control
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 43 people
- Sponsor
- Autonomic Technologies, Inc.
Episodic Cluster Headache
R-Verapamil for the Prophylaxis of Episodic Cluster Headache
This is a double-blinded, randomized, parallel, placebo-controlled phase 2 study to evaluate the safety and efficacy of R-verapamil in the prophylaxis of episodic cluster headache.
- Trial name
- NCT02209155
- Testing
- R-verapamil 75 mg tablet
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Center Laboratories, Inc.
Cluster Headache
The Efficacy of L-cysteine in Prevention of Cluster Headache
The purpose of this study is to validate the novel hypothesis that daily use of L-cysteine (Acetium® capsules) is an effective means to decrease the frequency of (or completely abort) the attacks of cluster headache.
- Trial name
- NCT02310828
- Testing
- Acetium
- Where
- 6 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Biohit Oyj
Chronic Cluster Headache
Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care
Subjects enrolled into this 10 week study will for the first two weeks document the number of cluster headaches and the means of treating (medication) of these attacks. Subjects will then be randomized to into either two groups.
- Trial name
- NCT01701245
- Testing
- GammaCore
- Where
- 10 sites in Belgium, Germany and 2 more
- Volunteers
- 97 people
- Sponsor
- ElectroCore INC
Episodic Cluster Headache
Civamide Nasal Solution for Cluster Headache
The purpose of this study is to evaluate the safety and efficacy of intranasally administered civamide nasal solution in the prevention of cluster headaches during an episodic cluster headache period.
- Trial name
- ECH (NCT01341548)
- Testing
- Civamide nasal solution 0.01%
- Volunteers
- 180 people
- Sponsor
- Winston Laboratories
Chronic Cluster Headache
A Study Comparing the Efficacy and Safety of Fremanezumab (TEV-48125) for the Prevention of Chronic Cluster Headache (CCH)
The purpose of the current study is to evaluate the efficacy and safety of Fremanezumab (TEV-48125), in the prevention of CCH in adult participants.
- Trial name
- NCT02964338
- Testing
- Fremanezumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 259 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Cluster Headache
Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches
This is a double-blind, placebo-controlled study. Subjects who meet the entry criteria will be randomized o receive one of three blinded treatments [C213 1.9 mg patch and placebo patch; C213 3.8 mg (1.9 mg x 2 patches), two…
- Trial name
- NCT04066023
- Testing
- C213 Microneedle System
- Where
- 12 sites in United States
- Volunteers
- 42 people
- Sponsor
- Zosano Pharma Corporation
Chronic Cluster Headache
A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.
The purpose of this clinical trial is to evaluate the safety and effectiveness of the Occipital Nerve Stimulation System (ONSS) in treating chronic cluster headache in adults.
- Trial name
- ONFIELD (NCT07677137)
- Testing
- Occipital Nerve Stimulation System
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Man and Science, SA
Cluster Headache, Episodic
Eptinezumab in Participants With Episodic Cluster Headache
The purpose of this study is to evaluate the efficacy of eptinezumab in participants with episodic Cluster Headache (eCH)
- Trial name
- ALLEVIATE (NCT04688775)
- Testing
- Eptinezumab
- Where
- 120 sites in United States, Belgium and 17 more
- Volunteers
- 231 people
- Sponsor
- H. Lundbeck A/S
Episodic Cluster Headache
Intranasal Civamide for Episodic Cluster Headache
This is a 49-day study to evaluate the effectiveness of Intranasal Civamide (Zucapsaicin) in the treatment of an episodic cluster headache period compared to placebo (medically inactive substance which does not contain any active…
- Trial name
- NCT00069082
- Testing
- Civamide (Zucapsaicin), Sodium Chloride
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Winston Laboratories
Cluster Headache
Data Collection on the ATI Neurostimulation System: SPG Stimulation for Cluster Headache
The primary objectives of the Registry are to: 1. Monitor the transfer of the ATI Neurostimulation System and its safety/clinical performance to a larger number of centers in the post market phase and 2.
- Trial name
- NCT01677026
- Where
- 11 sites in Denmark, Germany
- Volunteers
- 150 people
- Sponsor
- Autonomic Technologies, Inc.
Cluster Headache - Episodic and Chronic
Safety and Efficacy Study of SOM230 s.c. in Cluster Headache
The purpose of this study was to determine if SOM230 is safe and effective for the treament of cluster headache.
- Trial name
- NCT02619617
- Testing
- SOM230
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Resistant Migraine, Chronic Migraine Headache
A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine
The purpose of this pivotal clinical study is to evaluate the safety and effectiveness of the MySalvia System, a minimally invasive implantable neuromodulation therapy, for the preventive treatment of adults with resistant…
- Conditions
- Resistant Migraine, Chronic Migraine Headache, Headache (Migraine), Headache, Cluster
- Trial name
- RECLAIM-II (NCT07719608)
- Testing
- Neurostimulator
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Salvia BioElectronics
Chronic Cluster Headache
Cephalic Vascular Recording Upon SPG Stimulation
Hypothesis: Stimulation of the SPG at high frequencies (50-200Hz) is believed to cause a physiological parasympathetic block which decreases VMCA oxyHb concentration and cephalic vessel diameter.
- Trial name
- NCT01359631
- Volunteers
- 7 people
- Sponsor
- Autonomic Technologies, Inc.
Episodic Cluster Headache, Chronic Cluster Headache
A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache
The main purpose of this study is to assess the long-term safety and tolerability of galcanezumab administered up to once monthly in participants with episodic or chronic cluster headache who have completed study I5Q-MC-CGAL…
- Trial name
- NCT02797951
- Testing
- Galcanezumab
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 165 people
- Sponsor
- Eli Lilly and Company
Cluster Headache
A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.
The study will look at a non-invasive treatment for people suffering with chronic and episodic headaches. Study subjects will be randomized to an active treatment or an in-active treatment for 2 weeks.
- Trial name
- NCT01958125
- Testing
- gammaCore
- Where
- 9 sites in Denmark, Germany and 2 more
- Volunteers
- 102 people
- Sponsor
- ElectroCore INC
Chronic Cluster Headache
REsponse to Combined SONS and ONS in Chronic Cluster headachE
The purpose of this study is to demonstrate the safe use of the PRIMUS System in subjects with chronic cluster headache. This is a single-centre, open label, prospective, first in human study to collect initial clinical data on…
- Trial name
- RESPONSE (NCT05868044)
- Testing
- PRIMUS
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Salvia BioElectronics