Clinical trials: Treatment Side Effects
Advanced Gynecologic Tumors, TIL Engineered With Membrane-Binding Cytokine
A Study of GC203 TIL in Advanced Gynecologic Tumors (10hospital)
This study is to investigate the safety and efficacy on TIL engineered with membrane-binding cytokine (GC203 TIL) for the treatment of patients with advanced gynecologic tumors.
- Conditions
- Advanced Gynecologic Tumors, TIL Engineered With Membrane-Binding Cytokine, Treatment Side Effects, Effects of Immunotherapy
- Trial name
- NCT05468307
- Testing
- Membrane Bound Cytokine Modified TIL
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Juncell Therapeutics
Lung Cancer, Small Cell, Lung Cancer Metastatic
NutriCare Plus a Medically Tailored Meal Intervention Among Patients With Lung Cancer
The NutriCare study aims to develop, implement, and evaluate the efficacy of an innovative intervention strategy (medically tailored meals plus nutrition counseling) to integrate nutrition into the standard of care for oncology…
- Conditions
- Lung Cancer, Small Cell, Lung Cancer Metastatic, Lung Cancer Recurrent, Treatment Side Effects
- Trial name
- NCT04986670
- Testing
- Nutritional Counseling, Medically Tailored Meals (MTMs), Nutrition Prescription
- Where
- 4 sites in United States
- Volunteers
- 299 people
- Sponsor
- Tufts University
Cancer, Psychosocial Functioning
Body Composition and Psychosocial Factors in ICI-Treated Cancer Patients
Evaluation of the effects of body composition, psychosocial factors, and drug-related problems on clinical progression (such as toxicity, treatment response, and quality of life) in cancer patients treated with immune checkpoint…
- Conditions
- Cancer, Psychosocial Functioning, Treatment Side Effects, Cachexia
- Trial name
- NCT07130981
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Hacettepe University
Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Sex, Psychopharmacology, and Diabetes
The term sexual (SD) dysfunction covers conditions that prevent people from having a satisfactory sex life. SD is a frequent and sometimes debilitating complication of mental illness and a known adverse reaction to…
- Conditions
- Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Diabetes Mellitus, PreDiabetes
- Trial name
- SECRET (NCT05951660)
- Testing
- Educational intervention
- Where
- Denmark
- Volunteers
- 256 people
- Sponsor
- Zealand University Hospital
Depression - Major Depressive Disorder, Cognitive Flexibility
Cognitive Flexibility in Depression and TMS Response
The primary aim of this study is to determine the level of cognitive flexibility in patients with TRD before treatment and to explore whether there is a relationship with their response to TMS treatment.
- Conditions
- Depression - Major Depressive Disorder, Cognitive Flexibility, Treatment Response, Side Effects
- Trial name
- CogFelx_TMS (NCT06775054)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Cancer, Nurse's Role
Orem's Self-Care Deficit Theory Based Nursing Interventions for Immunotherapy Treated Cancer Patients
Objective: The aim of this study was to determine the effects of nursing interventions based on Orem Self-Care Deficiency Theory on symptom management, care needs and quality of life in cancer patients who underwent…
- Conditions
- Cancer, Nurse's Role, Treatment Side Effects, Quality of Life
- Trial name
- NCT05652764
- Testing
- Orem's Self-Care Deficit Theory Based Nursing Interventions for Immunotherapy Treated Cancer Patients
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Leiomyoma, Uterine, Liver Injury
Liver Safety Assessment During Ulipristal Acetate Treatment for Uterine Fibroids (LISA)
Uterine fibroids are are the most common gynecological tumor. Among the pharmacological treatment options, ulipristal acetate (UPA) has proven to be effective in control of bleeding and reduction of size of fibroids.
- Conditions
- Leiomyoma, Uterine, Liver Injury, Treatment Side Effects
- Trial name
- LISA (NCT04004884)
- Testing
- Ulipristal Acetate
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Breast Cancer, Treatment Adherence
PACED-digitized Support During Adjuvant Endocrine Therapy
The research team want to investigate whether digital support, an app under preventive hormonal breast cancer treatment can lead to less late side effects, better quality of life and increased adherence to treatment.
- Conditions
- Breast Cancer, Treatment Adherence, Quality of Life, Treatment Side Effects
- Trial name
- NCT05084625
- Testing
- Digitized support
- Where
- 3 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Stockholm
Cardiotoxicity, Breast Cancer
NT-proBNP to Assess Trastuzumab-induced Cardiotoxicity
Trastuzumab-induced cardiotoxicity (TIC) will be monitored in patients with HER2+ breast cancer undergoing trastuzumab treatment before and after breast cancer surgery.
- Conditions
- Cardiotoxicity, Breast Cancer, Treatment Side Effects
- Trial name
- NCT06340516
- Testing
- Plasma NT-proBNP
- Where
- Sweden
- Volunteers
- 700 people
- Sponsor
- Vastra Gotaland Region
EGFR Gene Mutation, Drug-Related Side Effects and Adverse Reactions
Applying Mobile Healthcare Education to Improve Cutaneous Self-care Capability
The goal of this clinical interventional study is to compare the efficacy of mobile healthcare education in two ways (game-based or text-based) to improve cutaneous self-care capability in cancer patients receiving EGFR-based…
- Conditions
- EGFR Gene Mutation, Drug-Related Side Effects and Adverse Reactions, Cancer, Treatment-Related, Cancer
- Trial name
- NCT06291688
- Testing
- Mobile healthcare education game, Mobile healthcare education application
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Taiwan University Hospital
Treatment Side Effects, Colorectal Cancer
Surgery Versus Endoscopic Resection for Incompletely Removed Early Colon CAnceR
Randomized head-to-head comparison trial among patients who have undergone incomplete endoscopic resection of early colon cancer to evaluate the benefits, harms and burdens, as well as the ecological footprint and…
- Trial name
- SCAR (NCT06057350)
- Testing
- Tumor removal
- Where
- 3 sites in Norway, Poland
- Volunteers
- 304 people
- Sponsor
- Norwegian Department of Health and Social Affairs
Schizophrenia, Treatment-resistant Schizophrenia
Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis
SchizOMICS is a Phase IV, multicenter, dose-flexible, open-label, randomized controlled clinical trial to evaluate the efficacy and safety of aripiprazole versus paliperidone using multi-omics data in patients with a first…
- Conditions
- Schizophrenia, Treatment-resistant Schizophrenia, Side Effect, Lipid Metabolism Disorders
- Trial name
- SchizOMICS (NCT06060886)
- Testing
- Aripiprazole, Paliperidone
- Volunteers
- 244 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Treatment Side Effects
Development and Testing of a TTDSS for Cancer Patients
This study aimed at testing the technical and clinical feasibility of the Mandarin Version of the electronic patient self-Reporting of Adverseev ents (eRAPID-MV) and the telephone triage decision support system (TTDSS) by testing…
- Trial name
- TTDSS (NCT05446051)
- Testing
- the Mandarin Version of the electronic patient self-Reporting of Adverse-events (eRAPID-MV), the telephone triage decision support system (TTDSS)
- Where
- Taiwan
- Volunteers
- 136 people
- Sponsor
- St. Martin De Porress Hospital
Treatment, Treatment Side Effects
Assessing an Oral EGFR Inhibitor,YK-209A in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR
This study aimed to evaluate the safety and preliminary efficacy of YK-029A, a novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in treated or untreated patients with advanced non-small…
- Trial name
- NCT05767866
- Testing
- YK-029A
- Where
- 35 sites in China
- Volunteers
- 160 people
- Sponsor
- Suzhou Puhe Pharmaceutical Technology Co., LTD
Drug-Related Side Effects and Adverse Reactions, Treatment Failure
DOAC ADRs Retrospective Study on Genetic Variations
The purpose of this study is to see if the participant's genetic profile and clinical factors (age, drug dose, etc.) affect drug outcomes (i.e.
- Trial name
- DARES1 (NCT04580589)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cipherome, Inc.
Clinical Efficacy, Treatment Efficacy
Lubiprostone for Functional Constipation in the Under 18 Years Patients
The investigators will enroll subjects 8 - < 18 years of age, fulfilling Rome IV criteria for functional constipation. Participants will be randomly assigned to either Lubiprostone treatment (study group), or the control group…
- Conditions
- Clinical Efficacy, Treatment Efficacy, Drug Side Effect
- Trial name
- NCT05144295
- Testing
- Lubiprostone Pill, Lactulose Oral Liquid Product, Bisacodyl 5 MG
- Where
- 2 sites in Egypt
- Volunteers
- 274 people
- Sponsor
- Alexandria University
Treatment Side Effects
Contralateral Effects of Russian Current on Adolescent Athlete
The strength loss associated with immobilization causes long term decreases in performance and loss of hours of participation for athletes during rehabilitation period to regain a competitive form.
- Trial name
- NCT04913350
- Testing
- Russian current, elbow support
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Misr University for Science and Technology
Endometrial Hyperplasia, Fertility Issues
A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore
The investigators' objective is to determine the regression rate, side effects and acceptability of Mirena compared to megace in the treatment of atypical endometrial hyperplasia among women desiring fertility.
- Conditions
- Endometrial Hyperplasia, Fertility Issues, Disease Regression, Treatment Side Effects
- Trial name
- NCT05492487
- Testing
- Mirena, Megace
- Where
- 3 sites in Singapore
- Volunteers
- 60 people
- Sponsor
- KK Women's and Children's Hospital
Treatment Side Effects
Lipid-lowering Agents in Patients With Dermatomyositis and Polymyositis
The use of lipid lowering agents in patients with idiopathic inflammatory myopathies is controversial. Therefore, the aim of the present study is to assess clinically and laboratory the impact of lipid-lowering agents in this…
- Trial name
- NCT03092154
- Testing
- Lipid-lowering agents (Artovastatin)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Stevens-Johnson Syndrome, Lyell Syndrome
Drug Reactions Sampling (COLLECTIONTOXIDERMIES)
Intro: Dermatology department of Henri Mondor Hospital (Creteil, France), is a reference center for toxic bullous diseases and severe cutaneous drug reactions (Stevens-Johnson syndrome (SJS), Lyell syndrome (toxic epidermal…
- Conditions
- Stevens-Johnson Syndrome, Lyell Syndrome, Drug Reactions, AGEP
- Trial name
- NCT03659227
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris