Clinical trials: Traumatic Brain Injury | Patient
Major Depression, Anxiety Disorder
Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression
A pilot study to evaluate the ability of photobiomodulation to alter cerebral blood flow in the frontal poles and to affect the emotional status of patients with major depression.
- Conditions
- Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
- Trial name
- NCT00961454
- Testing
- Photobiomodulation with a super-luminous light emitting diode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Mild Traumatic Brain Injury, Intracranial Lesions
TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms
The goal of this clinical study is to evaluate how accurately and safely the TES HT100 device can identify intracranial abnormalities in adult emergency department patients with mild head trauma or neurological symptoms that are…
- Conditions
- Mild Traumatic Brain Injury, Intracranial Lesions, Neurological Symptoms Not Related to Head Trauma
- Trial name
- TESCO (NCT07490418)
- Testing
- Temnographic Brain Screening Examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 850 people
- Sponsor
- B&B srl
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Endovascular middle meningeal artery (MMA) embolization is an emerging treatment for chronic subdural hematoma (cSDH). There is preliminary data to suggest that this minimally invasive therapy may be more efficacious and equally…
- Trial name
- NCT04065113
- Testing
- Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma
- Where
- United States
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injury
Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients
This study was conducted in two parts: 1. This first part was designed to determine thiopentone dose requirement for induction of anaesthesia with and without the use of Bispectral Index monitoring - Participant and Care Provider…
- Trial name
- NCT03480880
- Testing
- Bispectral Index
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Vestibular Rehabilitation
Vestibular Rehabilitation Exercise in Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of long-term disability and mortality. The costs associated with hospitalization, rehabilitation, and productivity losses after injury impose a significant socioeconomic and…
- Trial name
- NCT06118541
- Testing
- Vestibular Rehabilitation therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Brain Concussion, Brain Injuries
An Evaluation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Patients After Concussion
The HeadSense (HS) HS-1000 device, a new non-invasive brain monitor is expected to safely and accurately monitor concussed patients with minimal discomfort, potentially providing a new modality for concussion measurement.
- Trial name
- NCT02699346
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Traumatic Brain Injury
The Effect of Single Dose D-Cycloserine on Cognitive Outcome in Moderate Traumatic Brain Injury (TBI) Patients
In this study of patients with moderate traumatic brain injury with frontal brain contusions patients will be randomized to treatment with a single dose of either D-cycloserine or placebo given 48-72 hours after injury.
- Trial name
- DCS (NCT01343862)
- Testing
- D-cycloserine
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Traumatic Brain Injury
Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury
Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days.
- Trial name
- PREDICT-TCM (NCT04854954)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Brest
Traumatic Brain Injury
Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Brain Injury
The purpose of this study is to evaluate the effectiveness of nebulized lidocaine before Endotracheal suctioning (ETS) compared to instilled lidocaine and the effectiveness of aerosolized lidocaine versus instilled normal saline…
- Trial name
- NCT05058677
- Testing
- aerosolized 2% lidocaine (20mg/ml), instilled 0.9% sodium chloride (NS), instilled 2% lidocaine solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Minor Traumatic Brain Injury, Treatment by Antiplatelet
Interest of S100B Protein for Patient Victim of Minor Traumatic Brain Injury and Treated by Antiplatelet
All the patients admitted in emergency department for minor traumatized cranial, with antiplatelet therapy, can be included, after checked inclusion and non inclusions criterias.
- Trial name
- PETEChIA (NCT03780062)
- Testing
- S100B protein dosing
- Where
- 4 sites in France
- Volunteers
- 720 people
- Sponsor
- Poitiers University Hospital
Traumatic Brain Injury, Gait Disorders, Neurologic
Effect of High-Intensity Gait Training Using a Treadmill on Locomotion Recovery in Traumatic Brain Injury Patients
The project will consist of subjects who have suffered Traumatic Brain Injury (TBI) and who are able to ambulate on treadmill with or without a harness system.
- Trial name
- NCT05622786
- Testing
- HIGT - physical rehab, Low intensity physical therapy
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Traumatic Brain Injury
Biomarkers in Prehospital Rule-out of Intracranial Lesions in TBI Patients
The PreTBI I study will investigate whether prehospital blood samples drawn already in the ambulance can rule-out intracranial lesions in patients suffering head trauma.
- Trial name
- PreTBI I (NCT02867137)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 595 people
- Sponsor
- University of Aarhus
Partial Corticotrope Insufficiency
Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency
The purpose of this study is to evaluate the efficacy of hydrocortisone replacement therapy in patients with partial cortisol deficiency after traumatic brain injury or subarachnoid hemorrhage on cognitive function.
- Trial name
- CSMünchen01 (NCT01089075)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Brain Injuries, Craniocerebral Trauma
Observational Study of the BrainScope® Ahead™ M-100 in UK Emergency Department Patients With Head Injury
The purpose of the current study is proposed to prospectively assess how accurately the BrainScope® Ahead™ M-100 can distinguish risk categories for acute head injury.
- Trial name
- NCT01430988
- Where
- 3 sites in United Kingdom
- Volunteers
- 318 people
- Sponsor
- BrainScope Company, Inc.
Brain Injuries, Traumatic
Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan
The purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome.
- Trial name
- NCT00134472
- Testing
- Therapeutic mild hypothermia
- Where
- 43 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Yamaguchi University Hospital
Concussion, Brain
Oculomotor Function Testing in Acute Concussion
This is a prospective longitudinal study which aims to compare oculomotor function and visual scanning behaviour (VSB) of participants who suffered concussion with healthy controls with no concussion.
- Trial name
- NCT03892356
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Traumatic Brain Injury
Promoting Neuroplastic Changes of Patients With TBI
This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage…
- Trial name
- NCT06465290
- Testing
- Motor relearning training with wearable ankle robot, Passive stretching with wearable ankle robot, Gamed-based active movement training with wearable ankle robot
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Head Injury
Adjuvant Acupuncture for Severe Head Injury
The purpose of this study is to determine the therapeutic effect of acupuncture on severe head injury under conventional treatment.
- Trial name
- NCT01773291
- Testing
- acupuncture, laser acupuncture, control
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Traumatic Brain Injury, Healthy
Measuring Motor Imagery Ability in Patients With Traumatic Brain Injury.
1. Validation of translated Motor Imagery ability questionnaire MIQ-RS 2. Investigating the Motor Imagery ability in patients with traumatic brain injury
- Trial name
- NCT03315273
- Testing
- Test battery to measure the motor imagery ability
- Where
- Belgium
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Ghent