Clinical trials: Trauma Injury
Lung Transplantation
Lung and Diaphragm Ultrasound in the Early Postoperative Course Following Lung Transplantation
This feasibility study tries to define the value of daily Lung and Diaphragm Ultrasound in the early postoperative course following Lung transplantation by comparing its diagnostic accuracy with that of standard of care…
- Trial name
- LUS (NCT04891094)
- Testing
- Ultrasound
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cancer, Cisplatin Adverse Reaction
Effects of DPP4 Inhibitor on Cisplatin Induced Acute Kidney Injury
Cisplatin is a potent chemotherapeutic agent, however, its nephrotoxicity manifested by acute kidney injury (AKI) often limits applicability.
- Trial name
- NCT02250872
- Testing
- Gemigliptin, Cisplatin
- Where
- South Korea
- Volunteers
- 182 people
- Sponsor
- Seoul National University Bundang Hospital
Pelvic Trauma, Pelvic Fracture
A Snapshot Audit of Traumatic Pelvic Ring Injuries
Multicenter, snapshot cohort studies or audits have the ability to gather large patient numbers in short time periods from many healthcare systems with different resources or practices of care concerning one specific surgical…
- Conditions
- Pelvic Trauma, Pelvic Fracture, Fragility Fractures of the Pelvis (FFP)
- Trial name
- NCT06540339
- Testing
- Snapshot-audit studies do not necessitate any intervention in the defined cohorts.
- Volunteers
- 500 people
- Sponsor
- University Hospital, Aachen
Stroke, Incomplete Spinal Cord Injury
Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury
The purpose of the project is to compare intensity (minutes in target heart rate zone) and steps per session across three gait training modalities, including body-weight supported treadmill training (BWSTT), overground gait…
- Trial name
- NCT06169657
- Testing
- Body-weight-supported treadmill training (BWSTT), EksoNR exoskeleton gait training, Overground gait training
- Where
- United States
- Sponsor
- Shirley Ryan AbilityLab
Acute Pain
A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for the Treatment of Acute Pain in Pediatric Patients
The purpose of this study is to demonstrate the efficacy and safety of Intravenous (IV) acetaminophen plus rescue opioids for the relief of moderate to severe acute pain in neonates and infants (age < 2 years) compared to placebo…
- Trial name
- NCT01635101
- Testing
- IV Acetaminophen, IV Control
- Where
- 22 sites in United States
- Volunteers
- 197 people
- Sponsor
- Mallinckrodt
Post-traumatic Stress Disorder, Prehypertension
Sympathetic Overactivity in Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension.
- Trial name
- SO-PTSD (NCT01627301)
- Testing
- Device-Guided Breathing (DGB), Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Concussion, Mild, TBI (Traumatic Brain Injury)
Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Concussion Assessment
mTBI is widely recognized as a major public health concern in the United States and worldwide. mTBI diagnosis remains a clinical challenge as no single test can diagnose every concussion.
- Conditions
- Concussion, Mild, TBI (Traumatic Brain Injury), Mild Traumatic Brain Injury
- Trial name
- NCT03265912
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- ElMindA Ltd
Trauma to the Arm, Shoulder, Elbow, Forearm, or Hand
Ultrasound Visualization Versus Electrical Nerve Stimulation
Hypothesis and Specific Aims: The investigators hypothesize that ultrasound (US) visualization is as effective as nerve stimulation (NS) for identification of peripheral nervous structures and may be associated with less trauma…
- Trial name
- NCT01010412
- Testing
- Ultrasound (Sonosite Titan T-shaped ultrasound probe), Electrical Nerve Stimulation (Stimuplex (B Braun) needle)
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Allentown Anesthesia Associates
Lymphedema
Effect Of Complete Decongestive Therapy On Carpal Tunnel Syndrome Post Upper Limb Lymphedema
this study will be conducted to investigate the therapeutic effect of complete decongestive therapy on carpal tunnel syndrome post-upper limb lymphedema.
- Trial name
- CDT (NCT05932381)
- Testing
- Complete decongestive therapy, Medical treatment
- Volunteers
- 60 people
- Sponsor
- Cairo University
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Spinal Cord Injuries
Analysis of the Motion Activity Manual Wheelchair Users
Currently, there is no system in place to allow manual wheelchair users to know their quantities of movement activities and the intensity of effort to be provided during these propulsion movements.
- Trial name
- Acti-FRM (NCT04285970)
- Testing
- cycle detection, detection of effort intensity
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Subdural Hematoma
Effect and Safety Study of Atorvastatin to Treat Chronic Subdural Hematoma
To evaluate the clinic effects and security of oral administration of Atorvastatin on chronic subdural hematoma (CSDH).
- Trial name
- NCT02024373
- Testing
- Atorvastatin
- Where
- 31 sites in China
- Volunteers
- 200 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Intrusive Memories
The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories
The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog…
- Trial name
- NCT04871269
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Trapeziometacarpal Arthrosis, Carpal Tunnel Syndrome
A Randomized Trial Measuring the Effect of Decision Aids on Patients' Satisfaction, Conflict of Decision-making and Clinical Outcome
The investigators plan a prospective randomized controlled study that compares the treatment decisions made by patients who receive decision aids, as compared to patients treated with usual care and the American Society for…
- Conditions
- Trapeziometacarpal Arthrosis, Carpal Tunnel Syndrome, Cubital Tunnel Syndrome, Distal Radius Fractures
- Trial name
- NCT01693094
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Massachusetts General Hospital
Post-traumatic Stress Disorder
Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.
- Trial name
- REDUCTRAUMA2 (NCT01713556)
- Testing
- Propranolol, Trauma reactivation
- Where
- 4 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
Pressure Injuries, Wound Care
Effect of Two Different Solutions on Wound Healing in Pressure Injury
Pressure injuries are a condition that reduces patients' quality of life, increases hospitalization time and healthcare costs. When accompanied by infection and complications, mortality increases.
- Conditions
- Pressure Injuries, Wound Care, Wound Cleansing
- Trial name
- NCT06718777
- Testing
- 0.1% polyhexanide Care, 0.9 % NaCl Care
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Mensure Turan
Chylothorax, Esophageal Cancer
FLOTOR Pilot Study
This is a non-randomised study assessing the technique of using indocyanine green as a fluorescent dye to highlight the thoracic duct during oesophectomy.
- Conditions
- Chylothorax, Esophageal Cancer, Thoracic Duct Intra-Operative Injury
- Trial name
- FLOTOR (NCT03292757)
- Testing
- Indocyanine Green
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Anterior Cruciate Ligament Injury
MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation
This clinical trial evaluates interventions to maximize muscle function and improve cartilage health following anterior cruciate ligament reconstruction.
- Trial name
- MiACLR (NCT03626857)
- Testing
- Neuromuscular Electrical Stimulation (NMES), Eccentric Exercise (ECC)
- Where
- 2 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Michigan
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Immobilization
Time Performance of Scoop Stretcher Versus Vacuum Mattress for Prehospital Spinal Stabilization
A simulation-based randomized controlled trial was designed with the objective to assess the time needed to achieve spinal stabilization using a scoop stretcher compared to a vacuum mattress.
- Trial name
- NCT04904770
- Testing
- Scoop stretcher, Vacuum mattress
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stuby Loric