Clinical trials: Trauma Exposure
Posttraumatic Stress Disorders, Chronic Insomnia
Integrated CBT-I and PE on Sleep and PTSD Outcomes (Impact Study)
This study aims to examine whether integrating insomnia and PTSD treatment will enhance sleep, PTSD, and quality of life outcomes.
- Trial name
- NCT02774642
- Testing
- CBTI-PE, Hygiene-PE
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Early Prevention of Post Traumatic Stress Disorder
Sunnybrook Health Sciences Centre is Canada's largest trauma centre, treating 1,100 patients annually. A traumatic experience can lead to post-traumatic stress disorder, which increases hospital stays, emergency visits and…
- Trial name
- NCT02004743
- Testing
- Intervention, Treatment as usual
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Neoplasms, Radiation Pneumonia
Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort
Prospective cohort research to study the state of oxygen metabolism, reserve capabilities of cardiovascular and respiratory systems in patients with breast cancer to create a program of prevention and rehabilitation of lung…
- Conditions
- Breast Neoplasms, Radiation Pneumonia, Radiation Pneumonitis, Radiation Induced Fibrosis
- Trial name
- RELIEF-COHORT (NCT06069115)
- Testing
- Radiation therapy protocol for Breast cancer, Spirography and assessment of pulmonary diffusion capacity, Cardiopulmonary stress test
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Posttraumatic Stress Disorder
Suvorexant and Sleep's Benefits to Therapeutic Exposure for Posttraumatic Stress Disorder
The purpose of this study is to examine effects of blocking the orexin system with suvorexant after exposure-based intervention for posttraumatic stress disorder (PTSD) on sleep, PTSD symptoms, and intersession habituation.
- Trial name
- NCT02849548
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Howard University
Post-Traumatic Stress Disorder
MDMA-assisted Massed Prolonged Exposure for PTSD
The overall objective of this study is to pilot the VASDHS-adapted Emory MDMA-PE Protocol (aE-MDMA-PE) and assess the effect on clinician-rated PTSD symptoms in veterans who receive different doses of MDMA.
- Trial name
- MDMA-PE (NCT06117306)
- Testing
- 3,4 Methylenedioxymethamphetamine, Prolonged Exposure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Healing Breakthrough
Posttraumatic Stress Disorder, Substance Use Disorders
Adaptation of Written Exposure Therapy in Substance Treatment
The purpose of this pilot non-randomized, uncontrolled clinical trial is to test the feasibility and efficacy of written exposure therapy (WET) for posttraumatic stress disorder (PTSD) as adapted for use within the context of…
- Trial name
- WEST (NCT07108608)
- Testing
- Written Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Potomac Health Foundations
Sleep Disorders, PTSD
Efficacy of a Brief Nightmare Treatment for Veterans
The purpose of this study is to find out what effects Exposure, Rescripting, and Relaxation Therapy (ERRT) has on nightmares and associated problems in veterans.
- Conditions
- Sleep Disorders, PTSD, Suicide
- Trial name
- NCT01220401
- Testing
- exposure, relaxation, and rescription therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Tulsa
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Core Temperature, Heat Stress, Exertional
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part II
Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments.
- Conditions
- Core Temperature, Heat Stress, Exertional, Heat Fatigue, Exercise
- Trial name
- NCT06543719
- Testing
- Simulated work in the heat
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Trauma Treatment, Lifeline NET
Lifeline-NET (Narrative Exposure Therapy): A Short-term Treatment for Traumatized Refugees and Asylum Seekers
Evaluation of a short version of Narrative Exposure Therapy
- Conditions
- Trauma Treatment, Lifeline NET, Modification of Narrative Exposure Therapy
- Trial name
- NCT01720732
- Testing
- Lifeline NET
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Konstanz
Sarcopenia, Occlusion
Effectiveness of Focal Vibration and Blood Flow Restriction Within a Multicomponent Exercise Programme.
Sarcopenia can occur or increase due to sedentary lifestyles, physical inactivity or chronic endocrine and inflammatory disorders, this pathology is much more frequent in older people due to the added risk factors and the fact…
- Conditions
- Sarcopenia, Occlusion, Vibration; Exposure, Old Age; Atrophy
- Trial name
- NCT04940702
- Testing
- Focal Vibration, Blood Flow Restriction, Traditional Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universitat Internacional de Catalunya
Asthma, Hypertension
World Trade Center Adolescent Health Study
The proposed study builds upon preliminary studies in self-selected populations to identify opportunities for early identification of World Trade Center-related health consequences in adolescents.
- Conditions
- Asthma, Hypertension, Cardiovascular Risk Factor, Insulin Resistance
- Trial name
- NCT02068183
- Where
- United States
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
History of Exposure to Silica or Asbestosis, Positive Testing for ANA as a Marker of Systemic Autoimmune Diseases
Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages
Evaluation of the efferocytosis capacities of blood Monocyte Derived Macrophages (MDM) from patients with a history of asbestosis or silica exposure and comparison of these capacities with those of MDM from healthy donors.
- Trial name
- MacFibOsis (NCT04473742)
- Testing
- Blood collection, Blood sample
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Stress Disorders, Post-Traumatic
Prolonged Exposure Therapy for Post Traumatic Stress Disorder Following Sexual Assault
This study will evaluate the effectiveness of a brief cognitive behavioral therapy, administered by community agencies, for the treatment of patients with Post Traumatic Stress Disorder (PTSD).
- Trial name
- NCT00057629
- Testing
- Prolonged Exposure (PE), Treatment as usual group therapy (TUGT), Supportive counseling (SC)
- Where
- 2 sites in United States
- Volunteers
- 187 people
- Sponsor
- University of Pennsylvania
Posttraumatic Stress Disorder, Depression
Controlled Trial of Early Intervention With Children and Adolescents Exposed to Nonrelational Traumatic Events
Background: International studies have shown that a substantial number of children and adolescents are exposed to potentially traumatic events.
- Conditions
- Posttraumatic Stress Disorder, Depression, Anxiety
- Trial name
- NCT02299583
- Testing
- Preventive intervention trauma-informed early intervention
- Where
- Denmark
- Volunteers
- 684 people
- Sponsor
- Carolina Magdalene Maier
Traumatic Brain Injury, TBI
TWILIGHT Study: Effect of Light Exposure During Acute Rehabilitation on Sleep After TBI
This study proposes to investigate how well Bright White Light Therapy will work in the acute inpatient rehabilitation units for people whom have experienced a traumatic brain injury for the purpose of treating sleep disruption.
- Conditions
- Traumatic Brain Injury, TBI, Sleep
- Trial name
- TWILIGHT (NCT02214212)
- Testing
- Bright White Light (BWL), Red Light (RL)
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Washington
Psychological Trauma, Acute Coronary Syndrome
Brief Internet-delivered CBT After ACS
The purpose of the present pilot study is to evaluate the feasibility and potential efficacy of a brief, internet-delivered CBT protocol provided early after acute coronary syndrome (ACS).
- Trial name
- NCT05607992
- Testing
- Brief exposure-based CBT
- Where
- 2 sites in Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska Institutet
Posttraumatic Stress Disorder, Depression
Yoga Breath Program and Client-Centered Exposure for Relief of PTSD in Tsunami Victims
Study hypothesis: that a standardized course of Eastern practices (Breath Water Sound Course -BWS) will significantly relieve PTSD and depression in tsunami victims.
- Trial name
- NCT00290225
- Testing
- Breath Water Sound Course and Traumatic Incident Reduction
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Victim Services Center, Miami
Posttraumatic Stress Disorder
Telehealth-Massed Imaginal Exposure for PTSD
The purpose of this study is to establish the safety, feasibility, and acceptability of very brief imaginal exposure therapy for post-traumatic stress disorder (PTSD) delivered by telehealth over the course of six-daily 60-minute…
- Trial name
- NCT05450224
- Testing
- VVC-delivered Massed Imaginal Exposure
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder, Subsyndromal Posttraumatic Stress Disorder
Back on My Feet: Emotional Recovery From Fall Injury
We will compare two programs that are designed to help older adults who have had fall injuries manage anxiety and improve their level of functioning.
- Conditions
- Posttraumatic Stress Disorder, Subsyndromal Posttraumatic Stress Disorder, Fear of Falling
- Trial name
- NCT01998945
- Testing
- Exposure-based Cognitive Behavioral Therapy, Relaxation Training
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Weill Medical College of Cornell University