Clinical trials: Transjugular Intrahepatic Portosystemic Shunt
Hepatic Encephalopathy
Diet Management on Hepatic Encephalopathy of Patients With Variceal Bleeding After Intrahepatic Portosystemic Shunt Creation
Hepatic encephalopathy is a severe complication of transjugular intrahepatic portosystemic shunt (TIPS) treatment in patients with cirrhosis and variceal bleeding.
- Trial name
- DM-PTHE (NCT03372499)
- Testing
- diet management strategy for encephalopathy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Li Yang
Cirrhosis, Liver, Hepatorenal Syndrome
HRS-AKI Treatment With TIPS in Patients With Cirrhosis
The study compares the effectiveness and safety of TIPS implantation in patients with HRS-AKI (stage1, 2 and 3) and liver cirrhosis with standard therapy (drug therapy with terlipressin + albumin).
- Conditions
- Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
- Trial name
- Liver-HERO (NCT05346393)
- Testing
- TIPS, Standard of Care
- Where
- 14 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Jena University Hospital
Portal Hypertension
Electromagnetic Positioning-Assisted Ultrasound Guidance in Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) is an important method for treating complications related to portal hypertension. The difficulty of its surgical procedures lies in portal vein puncture.
- Trial name
- NCT06979622
- Testing
- ultrasound combined with electromagnetic positioning guidance
- Volunteers
- 20 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatic Encephalopathy, Liver Cirrhosis
Prediction of Post-TIPS Hepatic Encephalopathy in Patients With Liver Cirrhosis
Prediction of hepatic encephalopathy after insertion of a transjugular intrahepatic portosystemic stent shunt (post-TIPS HE) are critical for patient selection prior to TIPS insertion, and a currently unmet, clinically highly…
- Trial name
- NCT05466669
- Where
- 2 sites in Germany
- Volunteers
- 83 people
- Sponsor
- Johannes Gutenberg University Mainz
Liver Cirrhosis
Periinterventional Coagulation Management of Patients Undergoing a TIPS
Assess whether a pre-interventional thrombelastography guided algorithm for assessing and correction of coagulation status in cirrhotic patients is safe and effective
- Trial name
- TIPSprosp (NCT04421924)
- Testing
- thrombelastogram, standard of care
- Where
- Austria
- Volunteers
- 39 people
- Sponsor
- Medical University of Graz
Gastrointestinal Hemorrhage, Variceal Bleeding
Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy
Patients with liver cirrhoses and recent history of variceal bleeding, with HVPG documented non response to medical therapy with non selective beta blockers +/- mononitrates or variceal rebleeding during adequate medical therapy…
- Conditions
- Gastrointestinal Hemorrhage, Variceal Bleeding, Cirrhosis, Encephalopathy
- Trial name
- ENDOvsTIPS (NCT00570973)
- Testing
- endoscopic band ligation, TIPS-Implantation
- Where
- 4 sites in Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Portal Hypertension, Gastric Varices Bleeding
Preemptive TIPS for Gastric Variceal Bleeding in Patients With Cirrhosis
The prevalence of gastric varices is approximately 20%. It is important to note that gastric varices tend to bleed more severely, have a higher morbidity and mortality rate, and have a 35% to 90% risk of rebleeding after the…
- Conditions
- Portal Hypertension, Gastric Varices Bleeding, Portosystemic Shunt
- Trial name
- NCT06122792
- Testing
- preemptive TIPS, standard second prophylaxis
- Volunteers
- 144 people
- Sponsor
- West China Hospital
Decompensated Cirrhosis, Portal Vein Thrombosis
Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Prevention of Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
Portal vein thrombosis (PVT) refers to an obstruction in the trunk of the portal vein. It can extend downstream to the portal branches, or upstream to the splenic and/or the mesenteric veins.
- Conditions
- Decompensated Cirrhosis, Portal Vein Thrombosis, Bleeding Varices
- Trial name
- NCT01326949
- Testing
- Transjugular intrahepatic portosystemic shunt (TIPS), ET+NSBB
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Air Force Military Medical University, China
Hepatic Encephalopathy
Post Transjugular Intrahepatic Portosystemic Shunt (Tips) Albumine Infusion to Prevent Hepatic Encephalopathy
The purpose of this study is to evaluate the efficacy of albumin infusion to prevent post tips hepatic encephalopathy'
- Trial name
- NCT01559519
- Testing
- Albumin
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Portal Vein Thrombosis
Nadroparin Versus TIPS in Cirrhotic Patients With Refractory Asymptomatic PVT
The purpose of this study is to evaluate the comparative effectiveness of nadroparin versus transjugular intrahepatic portosystemic shunt in cirrhotic patients with refractory asymptomatic portal vein thrombosis using a design of…
- Trial name
- NCT06319131
- Testing
- TIPS, Nadroparin
- Volunteers
- 84 people
- Sponsor
- Shanghai Zhongshan Hospital
Portal Hypertension Related to Cirrhosis
Small Diameter TIPS in Patients with Severe Liver Atrophy and Variceal Bleeding
Portal hypertension is the most common complication in patients with end-stage liver cirrhosis. Portal hypertension-related complications, such as variceal bleeding, often lead to a poor prognosis.
- Trial name
- NCT06589531
- Testing
- During TIPS operation, shunt diameter or diameter of covered stent
- Volunteers
- 120 people
- Sponsor
- Huang Mingsheng
Hepatic Encephalopathy, Liver Cirrhosis
Effect of Mini-Program Monitoring on Hepatic Encephalopathy in Post-TIPS Patients
This study is a prospective, multicenter, randomized controlled clinical trial. It aims to evaluate whether an early monitoring and warning system based on a smartphone mini-program can effectively reduce the incidence of overt…
- Trial name
- NCT07901556
- Testing
- Standard Care and Routine Follow-Up, Hepatic Encephalopathy Intelligent Monitoring Mini-Program
- Volunteers
- 394 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Refractory Ascites
Transjugular Intrahepatic Portosystemic Shunts Improve Survival in Patients With Cirrhosis and Recurrent Ascites
Currently, there is limited evidence regarding the survival benefit of early transjugular intrahepatic portal shunt (TIPS) placement in patients with cirrhosis and recurrent ascites.
- Trial name
- TIPS (NCT06196723)
- Testing
- transjugular intrahepatic portal shunt
- Where
- 3 sites in China
- Volunteers
- 462 people
- Sponsor
- Tang-Du Hospital
Compensated Advanced Chronic Liver Disease, Portal Hypertension
The Precise Selection of Stent Diameter for Portal Hypertension Patients With TIPS
The precise planning of TIPS, especially individual selection of stent diameter, is a hot and difficult topic in the field. We have successfully developed a non-invasive technology to evaluate hepatic venous pressure gradient and…
- Trial name
- NCT04421118
- Testing
- a non-invasive technology to evaluate hepatic venous pressure gradient and portal pressure gradient
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Ascites, Variceal Bleeding
VIATORR® TIPS Study Evaluating 6-10mm Diameters (VIATIPS)
This Registry will look at patients being treated with a transjugular intrahepatic portosystemic shunt (TIPS) procedure for portal hypertension.
- Conditions
- Ascites, Variceal Bleeding, Portal Hypertension Related to Cirrhosis
- Trial name
- VIATIPS (NCT07390344)
- Testing
- GORE® VIATORR® TIPS Endoprosthesis with Controlled Expansion (6-10mm)
- Where
- 3 sites in United States
- Volunteers
- 152 people
- Sponsor
- W.L.Gore & Associates
Liver Cirrhoses
Efficacy and Safety of Early TIPS (Transjugular Intrahepatic Portosystemic Shunts) in the Management of Cirrhosis With Recurrent Ascites.
All consecutive patients with cirrhosis of liver who satisfy the criteria will be included and will be evaluated clinically along with all routine investigations and standard medical therapy will be continued among these…
- Trial name
- NCT04013074
- Testing
- Transjugular Intrahepatic Portosystemic Shunt, Standard Medical Treatment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Vein Thrombosis
Clinical Course of Cirrhotic Patients With Portal Vein Thrombosis Treated With TIPS
Portal vein thrombosis (PVT) is defined as an obstruction of the portal vein. The prevalence of PVT is 10-25% and incidence is about 16% in cirrhotic patients.
- Trial name
- NCT03031717
- Testing
- Transjugular intrahepatic portosystemic shunt
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hypertension, Portal
Virtual Imaging-based Early Portal Pressure Gradient (vePPG) (CHESS1702)
Portal pressure gradient (PPG) above 12 mmHg after transjugular intrahepatic portosystemic shunt (TIPS) increases the risk of portal hypertension complications.
- Trial name
- vePPG (NCT03177499)
- Testing
- Invasive PPG
- Where
- 10 sites in China
- Sponsor
- Nanfang Hospital, Southern Medical University
Cirrhosis, Liver, Hypertension, Portal
TIPS Plus Transvenous Obliteration for Gastric Varices
Variceal hemorrhage (VH) from gastric varices (GVs) results in significant morbidity and mortality among patients with liver cirrhosis.
- Conditions
- Cirrhosis, Liver, Hypertension, Portal, Esophageal and Gastric Varices, Bleeding Gastric
- Trial name
- NCT04044248
- Testing
- TIPS-obliteration
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Illinois Chicago
Portal Hypertension, Liver Diseases
Achieving Portal Access With Scorpion Post-Approval Study 2
Creation of the parenchymal tract between the portal vein and the hepatic vein is the most difficult and time consuming step in a TIPS procedure.
- Conditions
- Portal Hypertension, Liver Diseases, Ascites Hepatic, Hydrothorax
- Trial name
- APASS2 (NCT06856655)
- Testing
- Scorpion Portal Vein Access Kit
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Argon Medical Devices