Clinical trials: Transgender Persons
HIV Infections
PrEP2Prevent An Online PrEP Navigation and Activation Intervention
The goal of this clinical trial entitled, PrEP2Prevent: An Online PrEP Navigation and Activation Intervention for YMSM, is to develop and test a method for supporting access to an HIV prevention medication called Pre-Exposure…
- Trial name
- P2P (NCT05281393)
- Testing
- PrEPresent
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
HIV
Promoting Viral Suppression Among Transgender Women Living With HIV in Santo Domingo
This study includes an adapted multilevel intervention, Abriendo Puertas (Opening Doors), including individual counseling, peer navigation, and community mobilization for transfeminine people living with HIV in the Dominican…
- Trial name
- NCT06316102
- Testing
- Gender Affirming Abriendo Puertas (Opening Doors) (GAP)
- Where
- Dominican Republic
- Volunteers
- 139 people
- Sponsor
- University of North Carolina, Chapel Hill
Transgenderism, HIV Infections
Transgender Men's Perspectives on HIV Risk and HIV Prevention Interventions
The goal of this pilot study is to gather and analyze qualitative data from focus groups with Transgender men who have sex with men (TMSM) to learn more about the life experiences unique to TMSM that influence their attitudes and…
- Trial name
- NCT05666102
- Testing
- Transgender men's perspectives on HIV risk and HIV prevention interventions
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Substance Use Disorders, HIV
ASK-PrEP (Assistance Services Knowledge-PrEP)
ASK-PrEP is a two-arm randomized controlled trial (RCT), with a Stepped Care approach, among HIV-negative trans women and men who have sex with men with a substance use disorder (SUD).
- Trial name
- NCT05934877
- Testing
- PrEP navigation + text messaging, Standard of Care, Contingency Management
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Friends Research Institute, Inc.
Prevention
Adaptive Intervention to Facilitate PrEP Uptake/Adherence Among Transgender Women
"PrEP N' Shine" is a two-stage randomized controlled pilot trial which utilizes a behavioral intervention to optimize the uptake and adherence of Pre-exposure Prophylaxis (PrEP) in Transgender women (TGW).
- Trial name
- NCT05016232
- Testing
- PrEP N' Shine: Strength Based Case Management (Stage 1), PrEP N' Shine: Stepped Adherence Training and Counseling (Stage 2)
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Muscle Mass and Strength
Effects of Resistance Exercise Among TGD Individuals Initiating Estrogen-Based Gender-Affirming Hormone Therapy
Estrogen-dominant gender-affirming hormone therapy (GAHT) is standard of care for transgender women and gender-diverse individuals and typically consists of estrogen together with anti-androgen/ testosterone therapy.
- Trial name
- STRENGTH (NCT07400419)
- Testing
- Resistance Exercise Program, Nutrition and Exercise Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
PrEP Test and Treat
Evaluation of a Facility-based Test, Treat, and Prevent HIV Program Among Men Who Have Sex With Men and Transgender Women in Thailand
This is a prospective observational cohort study that aims to enroll a total of 2000 Thai MSM and TG at five health facilities in four provinces of Thailand. Each participant will be followed for 18 months.
- Trial name
- PrEP (NCT02369887)
- Where
- Thailand
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
HIV Infections
The Cheeky Study: A Novel Delivery System for CAB-RPV LA
This is a single-arm implementation study of a novel integrated delivery model of CAB-RPV LA for transwomen living with HIV.
- Trial name
- NCT05979714
- Testing
- Patient-centered injection site, Patient-centered adherence support, Provider education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Public Health Foundation Enterprises, Inc.
Sexual Health, Mental Health
Health Status of Transgender Women in French Guiana and Paris (TransGuyane)
Assessing and comparing the life and health status of transgender or trans women in French Guiana and Paris. Conducting a questionnaire on physical, mental and sexual health, migration history, transition, and STI screening.
- Trial name
- TransGuyane (NCT04962997)
- Testing
- Data collection
- Where
- 2 sites in France, French Guiana
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier de Cayenne
Sleep Disorder, Insulin Resistance
Sleep and IR in Transgender Adolescents
Disordered sleep is a health issue with significant impacts on physical and psychological well-being that has increased in prevalence, but its impact on transgender adolescents has not been fully quantified.
- Conditions
- Sleep Disorder, Insulin Resistance, Gender Dysphoria
- Trial name
- ATP (NCT05489159)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Injection; Complications, Sepsis, Injection Site Disorder
Transgender, Silicone and Blood Smear
This cross-sectional monocentric study will describe transgender men transitioning into women and who had cosmetic silicone injection.
- Conditions
- Injection; Complications, Sepsis, Injection Site Disorder, Injection Site Extravasation, Intentional Poisoning by Silicone
- Trial name
- TSBS (NCT02580760)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV, Sexually Transmitted Infections
Multicomponent Intervention to Reduce Sexual Risk and Substance Use
The objective is to expand and refine an intervention for transgender women (TW) into a 7-session individual- and group-based intervention that is scalable for community settings to reduce sexual risk and substance use and to…
- Conditions
- HIV, Sexually Transmitted Infections, Substance Use
- Trial name
- NCT01880489
- Testing
- MI + CBST Intervention
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04066283
- Testing
- No intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Transgender, HIV Continuum of Care
Assessing the Engagement of Transgender and Other Gender Minority Youth Across the HIV Continuum of Care
This study uses a transformative multiphasic mixed-methods research design that incorporates elements of the following designs: Sequential: a secondary data analysis was conducted, using data from ATN 039, ATN 086, and ATN 106…
- Trial name
- NCT02449629
- Where
- 14 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cervical Cancer Screening
HPV Self-Sampling for Cervical Cancer Screening Among Transgender Men and Transmasculine Individuals
The proposed study will examine the implementation of a Human Papillomavirus (HPV) self-sampling intervention for unscreened and under-screened transgender men and transmasculine individuals living in South Florida.
- Trial name
- NCT03222817
- Testing
- HPV self-sampling
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Miami
Neoplasms, Chronic Disease
Feasibility of Remote Activity Assessment and PRO Collection Among Transgender Cancer Survivors
Prospective observational feasibility study to evaluate the role of wearable activity monitors to determine the feasibility and acceptability of remote monitoring using wearable technology and PROs to monitor fatigue and physical…
- Trial name
- STRIDE (NCT05391217)
- Testing
- Remote assessment of patient reported outcomes and daily activity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Transgender, Transgenderism
Cardiometabolic Health in Transgender Males
Transgender individuals are those with a gender identity opposite the sex they were assigned at birth. Approximately 1% of the population is transgender, equating to ~60,000 transgender Wisconsinites.
- Trial name
- NCT04977765
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Mental Health Issue, Substance Use
mHealth Systems Navigation- Breaking Systems Barriers for Trans Women Living With HIV
The proposed study will test a mHealth peer navigation intervention for trans women living with HIV in a trans public health clinics to increase initiation and engagement in mental health and substance use services.
- Trial name
- mSN (NCT05196009)
- Testing
- mHealth peer navigation and social support
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV Infections
Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection Among Men and Transgender Persons Who Have Sex With Men
This study will evaluate the safety and efficacy of the human monoclonal antibody (mAb) VRC-HIVMAB060-00-AB (VRC01) in preventing HIV-1 infection among men and transgender (TG) persons who have sex with men, in North America…
- Trial name
- NCT02716675
- Testing
- VRC01
- Where
- 26 sites in United States, Brazil and 2 more
- Volunteers
- 2,699 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)