Clinical trials: Transgender Persons
Transgenderism, Kidney Diseases
Effect of Hormone Therapy on Renal Function
The purpose of this study is to understand the effects of testosterone or estradiol on kidney function in transgender adolescents and young adults.
- Conditions
- Transgenderism, Kidney Diseases, Kidney Injury
- Trial name
- NCT04482920
- Testing
- p-aminohippurate clearance study, Iohexol infusion
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
HIV
TechStep: Technology-based Stepped Care to Stem Transgender Adolescent Risk Transmission
TechStep is a three-arm, technology-based randomized controlled trial (RCT), with a stepped care approach, among high-risk HIV-negative transgender feminine, transgender masculine, and gender non-conforming youth and young adults…
- Trial name
- NCT04000724
- Testing
- Text Messaging (Text+Step), WebApp (App+Step), Information/No Step
- Where
- 5 sites in United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Smoking Cessation
Advancing Smoking Cessation Among Transgender
In partnership with a Community Advisory Board, the investigators developed TRANSformá tu salud (Spanish for TRANSform your health), a culturally adapted smoking cessation intervention for transgender and gender diverse…
- Trial name
- NCT07099287
- Testing
- TRANSform your health
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
HIV Infections
(mo)BETTA Trial in Transwomen for Optimization of ART
The purpose of this study is to determine the safety and tolerability of a new HIV medication, bictegravir plus emtricitabine plus tenofovir alafenamide (B/FTC/TAF, 3 HIV medications combined into one pill) in HIV-infected…
- Trial name
- (mo)BETTA (NCT03348163)
- Testing
- B/FTC/TAF, Current ART
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- The University of Texas Health Science Center, Houston
Transgenderism
Is Bioimpedance Analysis Accurate in Transgender Males?
Accurate fat mass and muscle mass assessment is an informative marker of an individual's health. However, the optimal method for assessing body composition in transgender males remains to be determined.
- Trial name
- NCT05728853
- Testing
- Assessment of body composition
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aalborg University Hospital
Transgender Persons
Transgender Observational Performance
The study will evaluate the sports capabilities of transgender women mainly in terms of muscular strength and aerobic capacity (VO2max).
- Trial name
- TOP (NCT05337865)
- Testing
- Aerobic exercise test.
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Brasileiro de Controle do Cancer
Acne Vulgaris
Clascoterone for Steroid-related Acne Vulgaris in Transgender Male Patients Receiving Masculinizing Hormone Therapy
Mechanism-based acne treatment for transgender patients receiving testosterone currently does not exist and is an unmet medical need. This study explores clascoterone to treat testosterone induced acne.
- Trial name
- NCT05891795
- Testing
- Clascoterone 1% Top Cream, Vehicle
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Stanford University
Gender Identity Disorder of Adult, Voiding Disorders
Transgender Post-reassignment Urogynecologic Measures and Perceptions
The intent of this mixed methods study for transgender women after gender confirmation surgery is to characterize and subsequently create a validated screening questionnaire for postoperative urologic and pelvic floor symptoms.
- Conditions
- Gender Identity Disorder of Adult, Voiding Disorders, Sexual Dysfunction
- Trial name
- NCT03293771
- Testing
- Focus group interviews, Questionnaire packet
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Gender Dysphoria
Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries
This study will compare the current standard-of-care pain treatment regimen options that are available to patients who undergo gender-affirming surgery.
- Trial name
- NCT04979338
- Testing
- Ultrasound guided Continuous Infraclavicular Brachial Plexus Block, Ultrasound guided Continuous Femoral Nerve Block, Ultrasound guided Pudendal Nerve Block
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- Cedars-Sinai Medical Center
Transgenderism, HIV Infections
Transgender Men's Perspectives on HIV Risk and HIV Prevention Interventions
The goal of this pilot study is to gather and analyze qualitative data from focus groups with Transgender men who have sex with men (TMSM) to learn more about the life experiences unique to TMSM that influence their attitudes and…
- Trial name
- NCT05666102
- Testing
- Transgender men's perspectives on HIV risk and HIV prevention interventions
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Testosterone, Transsexualism
Effect of Dose Fractionation of Testosterone Cypionate on Transgender Men with Erythrocytosis
A transgender man is someone with a male identity who were born with a vulva and vagina. The acquisition of masculine characters can come from surgery or from the use of testosterone.
- Conditions
- Testosterone, Transsexualism, Hematologic Diseases
- Trial name
- NCT05487794
- Testing
- Testosterone Cypionate 100 MG/ML
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
HIV/AIDS
Navigating Insurance Coverage Expansion (NICE)
The purpose of this research is to measure the effectiveness of an in-person assistance intervention on successful insurance enrollment, types of insurance coverage, rates of linkage to and retention in HIV-related health care…
- Trial name
- NICE (NCT04263441)
- Testing
- NICE Intervention
- Where
- 3 sites in United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Fertility Preservation, Parenting
Fertility Desires and Reproductive Needs of Transgender People
Majority of transgender and gender nonconforming people seeking medical care are in pubertal and reproductive age. Cross-sex hormones may compromise fertility especially when preceded by puberty blocking regimen.
- Conditions
- Fertility Preservation, Parenting, Gender Dysphoria
- Trial name
- PaFer (NCT03836027)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
HIV Infections
The Cheeky Study: A Novel Delivery System for CAB-RPV LA
This is a single-arm implementation study of a novel integrated delivery model of CAB-RPV LA for transwomen living with HIV.
- Trial name
- NCT05979714
- Testing
- Patient-centered injection site, Patient-centered adherence support, Provider education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Public Health Foundation Enterprises, Inc.
Transgenderism
Extracellular Vesicles and Endothelial Function in Transgender Subjects
Cardiovascular diseases are the leading cause of mortality. In women, the prevalence of cardiovascular diseases is lower and the presentation of coronary events often atypical.
- Trial name
- Evinge (NCT04971447)
- Testing
- gender affirming hormonal treatment in transgender men, gender affirming hormonal treatment in transgender women
- Volunteers
- 136 people
- Sponsor
- Central Hospital, Nancy, France
Gender Dysphoria
Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans
Transgender Veterans (trans Vets) frequently experience gender dysphoria or distress related to discord between their gender identity and birth sex.
- Trial name
- NCT06615401
- Where
- United States
- Volunteers
- 986 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Transgenderism, Cervical Cancer
Implementing HPV DNA Self-Collection to Increase Rates of Cervical Cancer Screening in Transgender Men
Transgender men are individuals born genetically female that have a gender identity that is incongruent with their biological sex.
- Conditions
- Transgenderism, Cervical Cancer, Human Papilloma Virus
- Trial name
- NCT04154358
- Testing
- HPV testing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Augusta University
Transgender, Gender Incongruence
China Gender-affirming Hormone Therapy Study
Data about transgender medical care, especially the gender-affirming hormone therapy (GAHT) is extremely insufficient in China. Few evidence exists in the physical and psychological effects of the hormonal treatment in Chinese…
- Trial name
- CGAHT (NCT05318755)
- Testing
- GAHT for transgender men, GAHT for transgender women
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Transgenderism, Catheter Related Complication
Safe Access for Bladder Entry in Transgender Men Following Penile Reconstruction
Inserting a urinary catheter in transgender men following penile reconstruction is difficult and usually requires specialist input.
- Trial name
- SAFE (NCT04454970)
- Testing
- Urethrotech Urethral catheterisation device (UCD), Bardia Aquafil long term catheter
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University College, London
Prevention
Adaptive Intervention to Facilitate PrEP Uptake/Adherence Among Transgender Women
"PrEP N' Shine" is a two-stage randomized controlled pilot trial which utilizes a behavioral intervention to optimize the uptake and adherence of Pre-exposure Prophylaxis (PrEP) in Transgender women (TGW).
- Trial name
- NCT05016232
- Testing
- PrEP N' Shine: Strength Based Case Management (Stage 1), PrEP N' Shine: Stepped Adherence Training and Counseling (Stage 2)
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles