Clinical trials: Transgender, open to volunteers
Transgender, Gender Incongruence
China Gender-affirming Hormone Therapy Study
Data about transgender medical care, especially the gender-affirming hormone therapy (GAHT) is extremely insufficient in China. Few evidence exists in the physical and psychological effects of the hormonal treatment in Chinese…
- Trial name
- CGAHT (NCT05318755)
- Testing
- GAHT for transgender men, GAHT for transgender women
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Gender Identity, Gender Dysphoria in Adolescents and Adults
Puberty, Testosterone, and Brain Development
Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache.
- Conditions
- Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
- Trial name
- NCT06670053
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Gender Dysphoria, Gender Dysphoria, Adult
Metoidioplasty and Phalloplasty Surgery Decision Making
The goal of this clinical trial is to test a new online tool designed to provide clear and understandable information to help individuals considering Metoidioplasty and Phalloplasty Surgeries (MaPS) make informed decisions The…
- Conditions
- Gender Dysphoria, Gender Dysphoria, Adult, Gender Incongruence, Transgenderism
- Trial name
- MaPS (NCT06565663)
- Testing
- MaPS Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Transgender Persons
Research Participation With Transgender and Gender-Diverse Youth
Research has historically excluded the participation of transgender and gender-diverse people. The purpose of this research study is to find out about what goes into a transgender and gender-diverse youth's decision to…
- Trial name
- NCT05927350
- Testing
- Survey
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Virginia Commonwealth University
Transgender Persons, Health Services for Transgender Persons
THE GUIDE: Transforming Health for Young Adults Using Interventions to Drive Engagement
This is a randomized controlled trial to test the effectiveness of an interactive educational app-based digital intervention that provides knowledge and support to transgender and gender-diverse (TGD) young adults ages 18-29…
- Conditions
- Transgender Persons, Health Services for Transgender Persons, Gender Identity
- Trial name
- NCT06177600
- Testing
- Interactive educational digital platform for transgender and gender-diverse (TGD) young adults and caregivers
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cancer Screening, Transgender
Cervical and Endometrial Cancer Screening in Patients Seeking Gender-Affirming Hysterectomy
This study aims to quantify the rates of cervical cancer screening and endometrial sampling prior to gender-affirming hysterectomy, assess the need for these tests in TGD individuals, and explore patient-centered options for…
- Conditions
- Cancer Screening, Transgender, Gender Diverse Populations
- Trial name
- NCT07075731
- Testing
- No intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Transgender Individuals, Gender Incongruence
Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - The SPECTRA Study
The goal of this observational study is to understand the factors influencing the well-being and health of transgender and gender-diverse (TGD) individuals undergoing gender-affirming therapies in Switzerland.
- Trial name
- SPECTRA (NCT06774053)
- Testing
- Group A (start of GAHT), Group B (on-going GAHT), Group C (GAS)
- Where
- 3 sites in Switzerland
- Volunteers
- 600 people
- Sponsor
- University Hospital, Basel, Switzerland
Transitioning Voice of Transgender and Gender Diverse People
Novel Delivery Method of Transgender Voice Modification Training Using a Mobile Application
The investigators hypothesize that the mobile application they developed for transgender and gender diverse individuals (TGGD) will be equivalent or better than traditional speech therapy in improving voice quality.
- Trial name
- NCT05815810
- Testing
- Attuned: A mobile application, In-Person Voice Modification Therapy
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Transgender, Gut Microbiome
Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach
The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors.
- Conditions
- Transgender, Gut Microbiome, Immune System, Cardiovascular Risk Factors
- Trial name
- XCVD (NCT05334888)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Kidney Disease, Kidney Injury
Transgender Analysis of Nephrological Studies Focused on Renal Metrics
This study investigates how sex hormones affect kidney function in people undergoing gender-affirming hormone therapy (GAHT). We know men have a faster progression of kidney disease.
- Conditions
- Kidney Disease, Kidney Injury, Transgender Individuals
- Trial name
- TRANSFORM (NCT07542964)
- Testing
- P-aminohippurate clearance study, Iohexol infusion, Hyperinsulinemic clamp
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Gender Affirmation Surgery, Perioperative Care
Support for Transgender and Non-Binary Individuals Seeking Vaginoplasty Study
The STRIVE study is the first national randomized trial to focus on improving well-being, access to surgical care and other health outcomes for transgender and nonbinary (referred to as trans) people seeking genital…
- Conditions
- Gender Affirmation Surgery, Perioperative Care, Transgender Health
- Trial name
- STRIVE (NCT06436560)
- Testing
- STRIVE Peer Support Intervention
- Where
- 9 sites in United States
- Volunteers
- 290 people
- Sponsor
- Oregon Health and Science University
Transgender, Gender Dysphoria in Adolescents and Adults
The Effect of Gender-affirmative Measures on Breast Perception in Trans Men
Breast dysphoria in transmasculine or genderdiverse individuals is a distinct psychological burden associated with depression, anxiety and suicidality.
- Trial name
- TRANSBREAST (NCT07252687)
- Testing
- quality of life questionnaire- iTransQoL, chest dysphoria measure
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University Innsbruck
Transgender Individuals
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.
The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes.
- Trial name
- NCT07394400
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Transgender
Gender Affirming Hormone Therapy and Immune Function in Trans Individuals - The GIFT Study
Our immune systems protect us from infection but can also cause disease, for example by attacking our own bodies (autoimmune disease), or driving chronic inflammation in conditions such as heart disease.
- Trial name
- GIFT (NCT07358897)
- Volunteers
- 500 people
- Sponsor
- Imperial College London
Meningococcal Meningitis, Serogroup B, Transgender Persons
Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons
Sexual differences are a well-established source of biological variation in immune system functioning, with men often displaying lower adaptive immune responses (e.g.
- Conditions
- Meningococcal Meningitis, Serogroup B, Transgender Persons, Sex Differences in Immune Response, Vaccination
- Trial name
- Vaxxygender (NCT06832514)
- Testing
- Serogroup B meningococal vaccine
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Ghent
Transgender Women
Progesterone in Gender Affirming Hormone Therapy Study
This study aims to study the effects of Oral Progesterone in Transgender Women. The primary goal is to study the effect of progesterone on psychological distress and secondarily on sleep quality, breast size, quality of life and…
- Trial name
- NCT06807580
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Transgender Persons, Pain Threshold
Perception of Pain During Gender Affirming Hormone Therapy
It is known from the literature that women and men differ in their perception of pain. Why this is the case has not been conclusively clarified. Sex hormones could have a significant influence on this.
- Conditions
- Transgender Persons, Pain Threshold, Perception of Pain, Sex Hormones
- Trial name
- NCT07148921
- Testing
- Quantitative Sensory Testing, Patient Health Questionnaire 9, Hormone concentrations
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Sexual Functioning, Transgender Men
Evaluating Sexual Functioning in Trans Men During the Gender Affirmation Process: A Mixed Methods Study
Both sexual experiences and the process of gender transition initiated to reduce gender dysphoria carry cultural characteristics.
- Conditions
- Sexual Functioning, Transgender Men, Gender Affirmation Surgery
- Trial name
- ESFTMGAP (NCT07131267)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Transgender Persons
Cohort Study on Factors Associated with the Evolution of Quality of Life Among Transgender Individuals in the French Population
This research focuses on identifying medical, social, and healthcare journey determinants associated with the evolution of quality of life in the transgender population at 12 months.
- Trial name
- TRANSPOSE (NCT06854965)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- CNGE Conseil
Transgender, Transgender Persons, M01.777.500
Changes in Energy Expenditure (EE) in Transsexuals Undergoing Hormonal Therapy
Examining Metabolic Rate in Transgender individuals before starting hormonal treatment and 6-12 months after initiation
- Trial name
- NCT06733415
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center