Clinical trials: Transcutaneous Vagal Nerve Stimulation (tVNS), open to volunteers
Acute Pain, Pain Perception
Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults
The goal of this clinical trial is to learn whether stimulating a nerve in the neck changes how much pain people feel. It also looks at whether this stimulation changes brain activity.
- Conditions
- Acute Pain, Pain Perception, Healthy Adult Participants
- Trial name
- NCT07827690
- Testing
- Active transcutaneous vagus nerve stimulation, Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- David A. Purger
Postpartum Depression (PPD), Postpartum Anxiety
Investigation of TVNS Administration on Postpartum Mental Health
The aim of the study is to explore whether transcutaneous vagus nerve stimulation (tVNS) may be effective in preventing mood swings and depressive symptoms in the postpartum phase, as well as serving as a supplementary…
- Conditions
- Postpartum Depression (PPD), Postpartum Anxiety, Postpartum Sadness, Postpartum Blues
- Trial name
- NCT06682689
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Cerebral
The Effect of Transcutaneous Vagal Nerve Stimulation (tVNS) on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
The significance of developing a safe and effective therapy for aneurysmal subarachnoid hemorrhage (aSAH) patients suffering cerebral vasospasm (CVS) cannot be overstated.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Cerebral, Transcutaneous Vagal Nerve Stimulation (tVNS), Endovascular Treatment
- Trial name
- NCT07131696
- Testing
- Transcutaneous Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Marshall Holland
Sjogren Syndrome
Fatigue in Sjögren's Syndrome: 3 Therapeutic Strategies
Unexplained fatigue is a frequent (60-70%) chronic complaint in Sjögren's syndrome (SjS) with a clear unmet therapeutic need, despite the recommendation of adapted physical activity (APA) programs, which are effective and…
- Trial name
- FESSONA (NCT06875102)
- Testing
- Acupuncture (ACU), Transcutaneous Vagus Nerve Stimulation (tVNS), APA (adapted physical activity )
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Stroke
Effects of Trans-Auricular Vagal Stimulation on Neuromotor Recovery in Subacute Stroke During Technological and Traditional Training
This randomized pilot clinical study aims to investigate the effects of trans-auricular vagus nerve stimulation (tVNS) on neuromotor recovery in patients in the subacute phase after stroke.
- Trial name
- NCT07254390
- Testing
- Active trans-auricular vagus nerve stimulation (tVNS), Khymeia robotic upper limb rehabilitation, Traditional Rehabilitation
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Fatigue Syndrome
Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue
Chronic fatigue is enhanced by adapted physical activity (APA) programs. Patients consulting on St Etienne hospital and suffering from fibromyalgia and long Covid benefit from a 4-6 week APA program, with 2 sessions per week.
- Trial name
- PAF-tVNS (NCT06170645)
- Testing
- APA program, Active transcutaneous VNS
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Transcutaneous Vagus Nerve Stimulation on Fibromyalgia
Transcutaneous Vagus Nerve Stimulation on Fibromyalgia- Double-blind, Sham-controlled Randomized Clinical Trial
Stimulation of the vagus nerve, a parasympathetic nerve that controls the digestive, the vascular and immune systems, produces pain relief in various clinical conditions.
- Trial name
- TVNS- Fibro (NCT06912334)
- Testing
- tVNS
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- National and Kapodistrian University of Athens
Sleep Disturbances, Insomnia
Home-Based Auricular Transcutaneous Vagus Nerve Stimulation (tVNS) for Sleep Quality and Psycho-Academic Outcomes in Health Sciences Students
This study aims to evaluate the efficacy, safety, and feasibility of a home-based auricular transcutaneous vagus nerve stimulation (tVNS) program in Health Sciences university students with poor sleep quality.
- Conditions
- Sleep Disturbances, Insomnia, Stress
- Trial name
- NEUROSLEEP (NCT07371715)
- Testing
- Auricular Transcutaneous Vagus Nerve Stimulation (tVNS)
- Volunteers
- 60 people
- Sponsor
- University of Malaga
Cancer-related Fatigue
Feasibility and Expansion Trial of Transcutaneous Vagus Nerve Stimulation (tVNS) for Immune-Related Fatigue in Patients Receiving Immune Checkpoint Inhibitors
This study evaluates whether a non-invasive device called transcutaneous vagus nerve stimulation (tVNS) can be safely and feasibly used to help reduce fatigue in patients receiving immunotherapy for cancer.
- Trial name
- NCT07529431
- Testing
- Participants will self-administer transcutaneous vagus nerve stimulation (tVNS) at home using a non-invasive auricular stimulation device for 60 minutes per day over a 6-week period. Participants will
- Volunteers
- 13 people
- Sponsor
- University of Vermont Medical Center
Subarachnoid Haemorrhage From Cerebral Aneurism Rupture
Investigating the Tolerability and Feasibility of tVNS Following aSAH
After a subarachnoid haemorrhage, complications are common and increase the overall rate of disability and death from the condition.
- Trial name
- tVNS in aSAH (NCT06374693)
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Stroke, Cerebrovascular Accident
Effects of tVNS and mCIMT in Chronic Stroke
Stroke is a leading cause of death and disability worldwide, resulting in significant physical and cognitive impairments. Arm weakness is most common after stroke and its treatment is recognized as an area of considerable need.
- Trial name
- NCT07272239
- Testing
- Transcutaneous Vagus Nerve Stimulation, Modified Constraint Induced Movement Therapy with Routine Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Transcutaneous Vagal Nerve Stimulation (tVNS), Diabetic Polyneuropathy
Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients
To evaluate the efficacy of vagus nerve stimulation in reducing neuropathic pain, symptom severity, electrophysiological studies and functional outcomes in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07405021
- Testing
- Conventional physical therapy program, Transcutaneous auricular vagus nerve stimulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Depression - Major Depressive Disorder
Slow-Paced Breathing and Electrical Vagus Nerve Stimulation as Add-on Treatments for Depression
Depression is a common mental health condition, and standard psychiatric therapies do not always lead to satisfactory recovery. As a result, there is an urgent need for effective, complementary treatments.
- Trial name
- Add-Vagus (NCT07844733)
- Testing
- Slow-Paced Breathing, Transcutaneous Auricular Vagus Nerve Stimulation (tVNS), Treatment as Usual (TAU)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Elisabeth Balint
Stress Response
Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks
This study examines how individuals respond to performance-related tasks and whether a non-invasive ear stimulation device influences stress responses during those tasks.
- Trial name
- NCT07470229
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS), Evaluative Stress Task
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida