Clinical trials: Transcutaneous Spinal Stimulation
Neurogenic Bladder, Urinary Retention
Qualitative Assessment of the Impact of TTNS on QOL and Participation
This study through the use of semi-structured interviews or focus groups will explore the lived experience with Transcutaneous Tibial Nerve Stimulation (TTNS) with Neurogenic Lower Urinary Tract Dysfunction to generate…
- Conditions
- Neurogenic Bladder, Urinary Retention, Urinary Tract Infections, Spinal Cord Injuries
- Trial name
- NCT04248322
- Testing
- Semi-structured interview
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Medstar Health Research Institute
Cerebral Palsy
tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy.
- Trial name
- NCT07433023
- Testing
- tSCS, 5-Azacitidine, Mannitol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Transformation of Paralysis to Stepping
The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis.
- Trial name
- NCT04105114
- Testing
- Buspirone, Non-invasive Spinal Cord Stimulation, Overground stepping
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Spinal Cord Injury, Orthostatic Hypertension
Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury
The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury.
- Conditions
- Spinal Cord Injury, Orthostatic Hypertension, Autonomic Dysreflexia
- Trial name
- NCT07504055
- Testing
- Spinal Cord Transcutaneous Stimulation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Louisville
Spinal Cord Injuries, Neurogenic Bladder
Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT
Spinal cord injury (SCI) disrupts many aspects of life, including the loss of volitional movement and involuntary control of bodily functions; both crucial functional recovery priorities for this population.
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Bowel
- Trial name
- MACHINE (NCT04726059)
- Testing
- Transcutaneous Spinal Cord Stimulation, Activity-Based Therapy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Chronic Stroke Survivors, Chronic Stroke Patients
Walking and tSCS in Non-ambulatory Stroke Survivors
Rehabilitation interventions commonly used for stroke survivors include task-specific training, balance and strength exercises, and the use of assistive devices to enhance mobility and independence.
- Conditions
- Chronic Stroke Survivors, Chronic Stroke Patients, Stroke
- Trial name
- NCT07226518
- Testing
- Robot-assisted gait training and transcutaneous spinal cord stimulation in chronic non-ambulatory stroke survivors: pilot RCT trial, Robot assisted gait training alone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Spinal Cord Injuries
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic…
- Trial name
- NCT04854057
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Spaulding Rehabilitation Hospital
Stroke
Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait…
- Trial name
- NCT05167786
- Testing
- Noninvasive spinal stimulation with gait training, Conventional gait training, Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury Cervical, Spinal Cord Injury, Acute
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury, Acute, Spinal Cord Injury (Quadraplegia)
- Trial name
- CIME_upperlimb (NCT07361627)
- Testing
- Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spinal Cord Injury, Quadriplegia/Tetraplegia
Home-Based Digital Rehabilitation Program Optimized With Transcutaneous Spinal Cord Stimulation for Upper Limb Functional Enhancement in Tetraplegia (HOPE): A Safety, Efficacy, and Feasibility Study
Individuals with chronic cervical spinal cord injury (SCI) and tetraplegia commonly experience persistent impairment in upper limb function, leading to reduced independence and quality of life.
- Trial name
- HOPE (NCT07438353)
- Testing
- Home-based digital rehabilitation programme with tSCS
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Singapore General Hospital
Orthostatic Hypotension
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal…
- Trial name
- NCT05960448
- Testing
- Transcutaneous Spinal Cord Stimulation (TSCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Motor Control in Incomplete Spinal Cord Injured Persons
Effects of Transcutaneous Spinal Cord Stimulation on Residual Voluntary Motor Control in Individuals With Incomplete Spinal Cord Injury
Recently, a transcutaneous protocol of electrical spinal cord stimulation (tSCS) has been developed. It was suggested, that this method could be used to improve the therapy process after a spinal cord injury (SCI).
- Trial name
- NCT03137108
- Testing
- Transcutaneous electrical spinal cord stimulation
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Psoriatic Arthritis
Transcutaneous Auricular Vagus Nerve Stimulation in Psoriatic Arthritis
This prospective single-center interventional study aims to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on disease activity, pain, quality of life, autonomic dysfunction symptoms, and…
- Trial name
- NCT07653009
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University
Amyotrophic Lateral Sclerosis (ALS), Dysphagia
Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS
Prospective, single-arm pilot study evaluating transcutaneous electrical nerve stimulation of the superior laryngeal nerve (TENS-SLN) in individuals with ALS.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Dysphagia, Dystussia
- Trial name
- NCT07606235
- Testing
- Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow
- Volunteers
- 5 people
- Sponsor
- Nova Southeastern University
Multiple Sclerosis, Transcranial Direct Current Stimulation
The Effects of Two Types of t-DCS Stimulation on Robot-assisted Gait Training in Patients With Multiple Sclerosis
The primary aim of this study is to determine the transcranial direct current stimulation and transcutaneous spinal direct current stimulation in addition to robot-assisted walking training in individuals with Multiple sclerosis…
- Trial name
- NCT06121635
- Testing
- Transcutaneous Spinal Direct Current Stimulation and Transcranial Direct Current Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istanbul Medeniyet University
Spinal Cord Injury
AI-Powered Closed-Loop Multielectrode Transcutaneous Spinal Cord Stimulation: Real-Time Adjustments for Enhanced Motor Recovery in Spinal Cord Injury (AIM RECOVER)
Spinal cord injury (SCI) often results in persistent motor deficits that are inadequately addressed by conventional rehabilitation.
- Trial name
- AIM RECOVER (NCT07452133)
- Testing
- Dynamic stimulation, Static stimulation
- Where
- Singapore
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury
Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups.
- Trial name
- NCT06242873
- Testing
- Gait training with/without TSCS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Spinal Cord Injuries, Stroke
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI).
- Trial name
- NCT06596369
- Testing
- Transcutaneous spinal cord stimulation, Upper extremity rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Spinal Cord Injury
Arm and Leg Cycling for Accelerated SCI Recovery
The purpose of this study is to examine interventions with paradigms involving upper and lower extremity cycling (A\&L cycling) with A\&L cycling with functional electrical stimulation (FES) (A\&L_FES group), A\&L cycling with…
- Trial name
- NCT06873776
- Testing
- A&L cycling, Body weight supported treadmill training (BWSTT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab