Clinical trials: Transcriptomics
Celiac Disease, Small Bowel Disease
Histomolecular Profiling in Small-Bowel Diseases
This prospective cohort study aims to establish reliable histological reference values for normal small-bowel mucosa, improve histological diagnostic quality in celiac disease, and develop an advanced molecular profile for…
- Conditions
- Celiac Disease, Small Bowel Disease, Refractory Celiac Disease
- Trial name
- Deep Bowel (NCT07556328)
- Where
- 3 sites in Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Lymphoma
Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma
To learn more about the usefulness of molecular testing with the Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care.
- Trial name
- NCT05464823
- Testing
- Molecular Functional Portrait
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Fertility
The Effect of Progesterone on Human Endometrium
This study evaluates the relationship between progesterone levels and endometrial gene expression
- Trial name
- NCT04323683
- Testing
- Microarray
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma
Real World and Genomic Data Based Asthma Insight Through Network Analysis
A retrospective and prospective observational study of asthma designed to determine real-world and molecular description of asthma according to treatment and type 2 biology
- Trial name
- REGAIN (NCT06623435)
- Where
- 5 sites in United States
- Volunteers
- 1,075 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Giant Cell Arteritis, Temporal Arteritis
Clonal Hematopoiesis in Giant Cell Arteritis
The goal of this clinical trial is to verify whether CHIP is correlated with the clinical, instrumental, and histological characteristics of GCA, and to characterize the pathogenetic effects of clonal hemopoiesis on vasculitis.
- Conditions
- Giant Cell Arteritis, Temporal Arteritis, Clonal Hematopoiesis of Indeterminate Potential, Horton Disease
- Trial name
- CH-GCA (NCT06244069)
- Testing
- Temporal arterial biopsy, Whole exome sequencing, Single cell transcriptomics
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Endotoxemia, Sepsis
Determining the Fingerprint of Endotoxin Tolerance
An explorative, prospective study in 100 healthy volunteers who will be challenged with endotoxin twice to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance
- Conditions
- Endotoxemia, Sepsis, Systemic Inflammation, Immunosuppresion
- Trial name
- 100LPS (NCT06801873)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
CMT, CMT (Charcot Marie Tooth Disease)
A Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)
The most common inherited neuropathy is Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication of the gene expressing PMP22.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), CMT - Charcot-Marie-Tooth Disease, CMT1A
- Trial name
- CMT-MODs (NCT07476365)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Amyotrophic Lateral Sclerosis
Muscular Biomarkers in Amyotrophic Lateral Sclerosis
The first objective is to find some biomarkers, or a profile of biomarkers of ALS to help to diagnosis. The second objective is to better understand the pathogenesis of this disease by the exploration of muscle, blood and…
- Trial name
- METABOMU (NCT02670226)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Sepsis, Immunologic Paralysis
Immune Homeostasis in Sepsis and Septic Shock
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
- Conditions
- Sepsis, Immunologic Paralysis, Immunologic Suppression, Immune Deficiency
- Trial name
- IMHOTEP (NCT04448951)
- Testing
- transcriptomics, flow-cytometry, cytokines
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Cardiovascular Disease
Decoding Your Diet (DYD)
Our study will determine if a high quality AHA plant-based diet intervention can promote a genetic signature that is protective against CVD.
- Trial name
- DYD (NCT05904639)
- Testing
- Decoding Your Diet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Physical Activity
Biomarkers of Physical Activity/health in Children and Adolescents
This clinical trial is aimed to recruit a core cohort of children and adolescents, and to perform an educational intervention and follow-up study in a subgroup of volunteers from this core cohort, to obtain specific measurements…
- Trial name
- INTEGRActiv (NCT05907785)
- Testing
- Educational intervention
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Autism Spectrum Disorder (ASD)
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups.
- Trial name
- ASD-Omics-TR (NCT06662591)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Research and Treatment Society of Genetic Disorders
Healthy
Lacticaseibacillus Rhamnosus GG Pili Study
The aim of this study was to investigate the host-microbe interaction effects of various Lacticaseibacillus rhamnosus GG strains, with different binding capacities to the mucus in the small intestine, in healthy individuals
- Trial name
- NCT05461443
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Feasibility Study, Vaccine Immune Response
How Gut Health Affects Immune Responses to the Oral Rotavirus Vaccine in Adults in Zambia
The Rotavirus SpatioTrasncriptomics (Rota-Omics) study is a multidisciplinary research project aimed at understanding why oral rotavirus vaccines perform less effectively in some low- and middle-income countries, including…
- Conditions
- Feasibility Study, Vaccine Immune Response, Rota Virus Gastroenteritis, Transcriptomics
- Trial name
- Rota-Omics (NCT07626606)
- Testing
- Rotarix®,
- Where
- Zambia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Cardiovascular Risk Factors
Beneficial Impact of Orange Juice Consumption on Risk Factors Associated With Cardiovascular Diseases
The primary aim is to examine both the acute and chronic effects of hesperidin consumption from 100% Florida orange juice in various doses on functional and systemic markers associated with cardiovascular disease (CVD) risks.
- Trial name
- CITRUS (NCT02479568)
- Testing
- Control, 100% Florida OJ, 100% Florida OJ-enriched
- Where
- Spain
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Cardiometabolic Disease
Metagenomics and Integrative Systems Medicine of Cardiometabolic Diseases
Supported by state-of-the-art systems medicine competences including integrative computational and functional genomics, the overarching goal of the trial is to investigate the impact of qualitative and quantitative changes in the…
- Trial name
- METACARDIS (NCT02059538)
- Testing
- Adipose tissue biopsies (omental and subcutaneous) liver, CT-scan, Stools sampling
- Where
- 3 sites in Denmark, France and 1 more
- Volunteers
- 2,350 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Soft Tissue Tumors of the Tongue, Squamous Cell Carcinoma
Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
Squamous cell carcinoma (SCC) could be a very aggressive cancer and has a bad prognosis if not detected early and thus is associated with high mortality.
- Conditions
- Soft Tissue Tumors of the Tongue, Squamous Cell Carcinoma, Proton Magnetic Resonance Spectroscopy, Transcriptomics
- Trial name
- ClimaBio (NCT06450080)
- Testing
- MRI and MRS acquisitions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens