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Clinical trials: Transcranial Alternating Current Stimulation

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20 studies

  • Mild Cognitive Impairment

    Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

    • Terminated
    • Age: 18 to 80 years
    • Medical device
    • Results posted

    Loss of slow wave sleep (SWS) is common in mild cognitive impairment (MCI) and Alzheimer's disease, and is thought to worsen thinking, memory and brain degeneration.

    Trial name
    NCT03112902
    Testing
    Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
    Where
    United States
    Volunteers
    24 people, healthy volunteers welcome
    Sponsor
    University of Colorado, Denver
    Can I take part? NCT03112902

  • Major Depressive Disorder, MDD

    Transcranial Alternating Current Stimulation for Major Depressive Disorder

    • Completed
    • Age: 18 to 65 years
    • Medical device
    • Results posted

    Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on patients with Major Depressive Disorder (MDD).

    Trial name
    MDD (NCT02339285)
    Testing
    tACS (alpha), tACS (gamma)
    Where
    United States
    Volunteers
    32 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? MDD

  • Major Depressive Disorder, MDD

    Mechanism of Action of tACS for the Treatment of MDD

    • Completed
    • Age: 18 to 70 years
    • Medical device
    • Results posted

    The purpose of this research study is to use a specific type of non-invasive brain stimulation known as transcranial alternating current stimulation (tACS) to determine its effects on brain activity (measured with EEG) and mood…

    Trial name
    GLADIATOR2 (NCT03994081)
    Testing
    tACS
    Where
    United States
    Volunteers
    20 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? GLADIATOR2

  • Bipolar Disorder

    Bipolar Transcranial Alternating Current Stimulation (tACS)

    • Completed
    • Age: 18 to 55 years
    • Medical device
    • Results posted

    The purpose of this clinical trial is to measure the safety and effectiveness of a non-invasive brain stimulation device called Transcranial Alternating Current Stimulation (tACS) in participants with bipolar disorder (BD).

    Trial name
    NCT05480124
    Testing
    tACS brain stimulation treatment
    Where
    United States
    Volunteers
    18 people
    Sponsor
    University of Michigan
    Can I take part? NCT05480124

  • Understand the Effects of tACS on the Brain

    Investigating Transcranial Alternating Current Stimulation (tACS) Preconditioning Effects on Resting and Active Motor Threshold

    • Terminated
    • Age: 18 to 95 years
    • Medical device
    • Results posted

    Previous studies have looked at the potential of using transcranial direct current stimulation (tDCS) to prime the brain in order to lower the resting motor threshold.

    Trial name
    NCT05503823
    Testing
    tACS or tRNS and TMS
    Where
    Canada
    Volunteers
    6 people, healthy volunteers welcome
    Sponsor
    University of Manitoba
    Can I take part? NCT05503823

  • Chronic Low Back Pain

    Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy

    • Completed
    • Age: 18 to 65 years
    • Medical device
    • Results posted

    Chronic pain is a severe disabling problem within society, affecting 25-30% of the United States population.. Transcranial alternating current stimulation (tACS) has the potential to provide a treatment option that is safe…

    Trial name
    BPS (NCT03243084)
    Testing
    XCSITE100 Stimulator tACS
    Where
    United States
    Volunteers
    21 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? BPS

  • Substance Use Disorders

    Non-Invasive Brain Stimulation and Substance Use

    • Completed
    • Age: 18 to 55 years
    • Medical device
    • Results posted

    The will investigate the feasibility and effectiveness and initial efficacy of non-invasive transcranial alternating current stimulation (tACS) on distress tolerance and inhibitory control among treatment seeking substance users.

    Trial name
    NCT03122587
    Testing
    Transcranial Alternating Current Stimulation at 10 Hz, Transcranial Alternating Current Stimulation at 40 Hz
    Where
    United States
    Volunteers
    38 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? NCT03122587

  • Alzheimer Disease

    tACS for Amyloid-β Reduction in Alzheimer's Disease

    • Completed
    • Age: 45 years and older
    • Medical device
    • Results posted

    Alzheimer's Disease (AD) is characterized by amyloid-β (Aβ) plaque buildup and phosphorylated tau (p-tau) in the brain, as well as widespread neurodegeneration.

    Trial name
    NCT03290326
    Testing
    Transcranial Alternating Current Stimulation (tACS)
    Where
    United States
    Volunteers
    17 people
    Sponsor
    Massachusetts General Hospital
    Can I take part? NCT03290326

  • Major Depressive Disorder

    Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression

    • Completed
    • Age: 18 years and older
    • Medical device
    • Lifestyle or therapy programme
    • Results posted

    Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can augment the effects of a single session of behavioral activation in participants with major depressive disorder.

    Trial name
    ABBA (NCT05693922)
    Testing
    Delta-beta cross-frequency transcranial alternating current stimulation via the NeuroConn DC-STIMULATOR MC, Single-session behavioral activation
    Where
    United States
    Volunteers
    30 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? ABBA

  • Depression, Major Depressive Disorder

    Single Session of tACS in a Depressive Episode

    • Completed
    • Age: 18 to 65 years
    • Medical device
    • Results posted

    Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders.

    Conditions
    Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
    Trial name
    SSDE (NCT03449979)
    Testing
    XCSITE100 Stimulator tACS
    Where
    United States
    Volunteers
    84 people, healthy volunteers welcome
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? SSDE

  • Depression, Major Depressive Disorder

    Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression

    • Completed
    • Age: 18 to 70 years
    • Medical device
    • Results posted

    The purpose of this research study is to study closed-loop transcranial alternating current stimulation (tACS) to determine its effects on symptoms of depression in people with major depressive disorder.

    Conditions
    Depression, Major Depressive Disorder, tACS
    Trial name
    CLACS (NCT05772702)
    Testing
    Closed-loop tACS
    Where
    United States
    Volunteers
    26 people
    Sponsor
    Electromedical Products International, Inc.
    Can I take part? CLACS

  • Systemic Lupus Erythematosus, Depression

    LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE

    • Terminated
    • Age: 18 to 65 years
    • Medical device
    • Results posted

    The purpose of this study is to investigate the effects of a type of non-invasive transcranial alternating current stimulation (tACS) on patients diagnosed with systemic lupus erythematosus (SLE) who are experiencing depression.

    Trial name
    NCT04141046
    Testing
    XCSITE100 Stimulator - Individualized theta-tACS, XCSITE100 Stimulator - Individualized alpha-tACS
    Where
    United States
    Volunteers
    4 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? NCT04141046

  • Working Memory

    Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

    • Completed
    • Age: 18 years and older
    • Medical device
    • Results posted

    This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.

    Trial name
    NCT04680481
    Testing
    Transcranial alternating current stimulation
    Where
    United States
    Volunteers
    11 people
    Sponsor
    University of Minnesota
    Can I take part? NCT04680481

  • Antenatal Depression, Major Depressive Disorder

    Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

    • Terminated
    • Age: 18 to 45 years
    • Medical device
    • Results posted

    The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.

    Conditions
    Antenatal Depression, Major Depressive Disorder, Major Depressive Disorder in Pregnancy, Healthy Controls
    Trial name
    PandA-tACS (NCT06979154)
    Testing
    tACS (aperiodic)
    Where
    United States
    Volunteers
    6 people, healthy volunteers welcome
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? PandA-tACS

  • Alzheimer Disease

    Effect of Modulating Gamma Oscillations Using tACS

    • Completed
    • Age: 45 years and older
    • Medical device
    • Results posted

    This study aims to implement an intervention based on multiple, individualized multifocal tACS stimulation sessions based on individual PET and MRI information in patients with amyloid-positive PET with the hope that this leads…

    Trial name
    NCT03412604
    Testing
    Transcranial Alternating Current Stimulation (tACS)
    Where
    United States
    Volunteers
    5 people
    Sponsor
    Massachusetts General Hospital
    Can I take part? NCT03412604

  • Multitasking Behavior

    At-home Transcranial Alternating Current Stimulation During Multitasking

    • Completed
    • Age: 18 to 35 years
    • Medical device
    • Results posted

    The goal is to replicate in-lab results from transcranial alternating current stimulation (tACS) with at-home tACS.

    Trial name
    NCT04231825
    Testing
    Transcranial alternating current stimulation
    Where
    United States
    Volunteers
    47 people, healthy volunteers welcome
    Sponsor
    University of California, San Francisco
    Can I take part? NCT04231825

  • Mild Cognitive Impairment

    Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory

    • Completed
    • Age: 55 to 80 years
    • Medical device
    • Results posted

    This project assessed the feasibility of transcranial alternating current stimulation in the gamma band to lower beta-amyloid load and improve memory performance.

    Trial name
    NCT04646499
    Testing
    Transcranial alternating current stimulation
    Where
    United States
    Volunteers
    14 people, healthy volunteers welcome
    Sponsor
    University of California, San Francisco
    Can I take part? NCT04646499

  • Major Depressive Disorder, Anhedonia

    Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia

    • Completed
    • Age: 18 to 65 years
    • Medical device
    • Results posted

    Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can increase goal-directed behavior in participants with major depressive disorder and elevated symptoms of anhedonia.

    Trial name
    DEBRA (NCT05084924)
    Testing
    Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
    Where
    United States
    Volunteers
    35 people
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? DEBRA

  • Transcranial Alternating Current Stimulation, Aging

    Effects of Gamma-tACS on Memory and Sleep

    • Completed
    • Age: 50 years and older
    • Medical device
    • Results posted

    The purpose of this clinical trial is to investigate the feasibility and efficacy of non-invasive transcranial alternating current stimulation (tACS) at gamma frequency in enhancing memory recall and modulating sleep network…

    Conditions
    Transcranial Alternating Current Stimulation, Aging, Cognitive Decline, Memory
    Trial name
    NCT05907707
    Testing
    Gamma transcranial alternating current stimulation, Control transcranial alternating current stimulation, EEG headband
    Where
    United States
    Volunteers
    11 people, healthy volunteers welcome
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? NCT05907707

  • Cognitive Control, Executive Function

    Effect of Cross Frequency tACS on Cognitive Control

    • Completed
    • Age: 18 to 35 years
    • Medical device
    • Results posted

    Investigation of frequency specific transcranial alternating current stimulation on cognitive control signals in frontal cortex

    Trial name
    NCT03800030
    Testing
    Theta-gamma tACS, Delta-beta tACS
    Where
    United States
    Volunteers
    26 people, healthy volunteers welcome
    Sponsor
    University of North Carolina, Chapel Hill
    Can I take part? NCT03800030

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