Clinical trials: Tranexamic Acid Use
Monocompartimental Tibiofemoral Osteoarthritis, Osteoarthritis
Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies
A randomised controlled double-blind clinical trial focused on the evaluation of the effectiveness of the tranexamic acid on bleeding, pain and wound complications reduction in tibial osteotomies.
- Trial name
- NCT04785651
- Testing
- Tibial osteotomy with Tranexamic acid, Tibial osteotomy without Tranexamic acid
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Istituto Ortopedico Rizzoli
Intracerebral Hemorrhage
Precision Use of TXA in Intracerebral Hemorrhage
Primary Intracerebral hemorrhage (ICH) is a severe and disabling disease. The hematoma will expand within the first few hours, which contributes to increasing brain injury and worsening neurological prognosis.
- Trial name
- NCT07365150
- Testing
- Tranexamic Acid (IV)
- Where
- 3 sites in Hong Kong
- Volunteers
- 70 people
- Sponsor
- The University of Hong Kong
Cerebral Palsy, Hip Surgery Corrective
Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy
TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip…
- Conditions
- Cerebral Palsy, Hip Surgery Corrective, Tranexamic Acid Use, Blood Loss, Surgical
- Trial name
- TABLO (NCT07672158)
- Testing
- Tranexamic Acid (IV)
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- Murdoch Childrens Research Institute
Osteoarthritis
Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement
Tranexamic acid (TXA) and ε-aminocaproic acid (EACA) are two drugs shown to limit blood loss following major surgery, from cardiac to orthopedic procedures.
- Trial name
- NCT01873768
- Testing
- Tranexamic Acid (TXA), ε-Aminocaproic Acid (EACA)
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Miller Orthopedic Specialists
Cancer of the Bone, Limb Salvage
Tranexamic Acid Use to Reduce Blood Transfusion in Pediatric Cancer Patients Undergoing Limb Salvage Procedure
This is a randomized double-blind control trial evaluating the use Tranexamic acid (TXA) to decrease blood loss and transfusion requirements in pediatric and young adult cancer patients undergoing a limb salvage procedure that…
- Trial name
- NCT04410042
- Testing
- Tranexamic Acid, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Jude Children's Research Hospital
Lung Transplant, Complications Surgical
Protest Trial: TXA vs Saline
To determine if endobronchial (topical) tranexamic acid used prophylactically prior to performing transbronchial biopsies in lung transplant recipients reduces bleeding risk.
- Trial name
- NCT06422273
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Corewell Health West
Tranexamic Acid Use, Blood Loss
Tranexamic Acid Use and Blood Loss in Total Hip Arthroplasty
The purpose of this study is to determine the need for a blood transfusion during surgery and to evaluate the levels of certain proteins in the blood when given tranexamic acid.
- Trial name
- NCT02989155
- Where
- United States
- Volunteers
- 576 people
- Sponsor
- Ohio State University
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Intracerebral Haemorrhage
STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units
The study is a prospective phase II randomised, double-blind, placebo-controlled investigator-driven trial in acute intracerebral haemorrhage patients.
- Trial name
- NCT03385928
- Testing
- Tranexamic Acid, Normal saline
- Where
- 25 sites in Australia, Finland and 3 more
- Volunteers
- 201 people
- Sponsor
- Neuroscience Trials Australia
Hypotension During Surgery, Blood Loss, Surgical
Reducing Hypotensive Anesthesia Use With TXA During Orthognathic Surgery
This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered.
- Trial name
- NCT05474027
- Testing
- Avoidance of Deliberate Hypotensive Anesthesia, TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis, Knee
Tranexamic Acid and Drain Use in Knee Arthroplasty
This prospective randomized clinical study is designed to evaluate the effects of intra-articular tranexamic acid (TNA), with or without suction drainage, on perioperative blood management in patients undergoing total knee…
- Trial name
- TNAKnee (NCT07174895)
- Testing
- Intra-articular Tranexamic Acid + Suction Drainage, Intra-articular Tranexamic Acid, Suction Drainage Only
- Where
- Syria
- Volunteers
- 192 people
- Sponsor
- Idlib University
Knee Osteoarthritis, Blood Loss
Use of Tranexamic Acid in the Total Knee Arthroplasty.
Tranexamic acid is a medication used to treat or prevent excessive blood loss during surgery. Previous studies have shown tranexamic acid (TXA) reduces blood loss and post-operative blood transfusion rate without significant…
- Conditions
- Knee Osteoarthritis, Blood Loss, Blood Transfusion
- Trial name
- NCT05919615
- Testing
- Tranexamic Acid 100 MG/ML, Normal saline
- Where
- Syria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Damascus University
Major Non-cardiac Surgeries
A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery
A Phase IV trial of a hospital policy of Tranexamic acid to reduce transfusion in major non-cardiac surgery.
- Trial name
- TRACTION (NCT04803747)
- Testing
- Tranexamic acid (TXA)
- Where
- 10 sites in Canada
- Volunteers
- 8,421 people
- Sponsor
- University of Manitoba
Hematoma, Seroma
Tranexamic Acid for Bleeding in Breast Surgery
Bleeding is an important consideration in breast surgeries that involve large resections of soft tissues in the breast. Inappropriate bleeding during or after surgery, can lead to uncomfortable fluid buildup in the breasts known…
- Trial name
- TABBS (NCT02615366)
- Testing
- Tranexamic Acid
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Obese Patients, Obese Patients With Bariatric Surgery
Intravenous Tranexamic Acid
Tranexamic acid is a promising option for minimizing blood loss in high-risk bariatric surgery patients, particularly in those with obesity, diabetes, and other comorbidities.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Bleeding
- Trial name
- TXA (NCT07192640)
- Testing
- After induction of anaesthesia tranexamic acid will be administered at the start of surgery to reduce intraoperative bleeding. loading dose of 10 mg/kg for high BMI patients who are undergoing bariatr
- Where
- Saudi Arabia
- Volunteers
- 128 people
- Sponsor
- Ain Shams University
Postoperative Bleeding
Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
Tranexamic acid (TXA) is an anti-fibrinolytic agent developed in the 1960s that has been safely used to reduce blood loss, transfusion rates and bleeding-associated mortality in trauma, obstetrics and orthopedic surgery…
- Trial name
- TXA (NCT06208267)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Tendon Injury - Hand
Tranexamic Acid Effect on Digit Function Following Primary Repair of Traumatic Digit Flexor Tendon Injuries
This study evaluates the effect of pre-operative treatment with IV Tranexamic Acid on post-operative digit function, in patients that underwent surgical repair of traumatic zone 1 or zone 2 digit flexor tendon tear.
- Trial name
- NCT04178655
- Testing
- Tranexamic acid injection
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Acute Hip Fractures
Tranexamic Acid Use in Acute Hip Fractures
BACKGROUND: Tranexamic acid (TXA) has been used widely for the reduction of post operative blood loss for various orthopaedic procedures including but not limited to total hip arthroplasty and total knee arthroplasty.
- Trial name
- NCT02947529
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Carilion Clinic
Spinal Fusion, Antifibrinolytic Agents
Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Tranexamic Acid on Transfusion Requirements and Surgical Bleeding in Major Spine Surgery
Current evidence regarding the efficacy and safety of perioperative administration of tranexamic acid for antifibrinolysis does not suffice to support its use in major spinal surgery.
- Conditions
- Spinal Fusion, Antifibrinolytic Agents, Hemorrhage, Blood Transfusion
- Trial name
- NCT01136590
- Testing
- Tranexamic Acid, fisiologic serum
- Where
- 4 sites in Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Ewing Sarcoma of Bone, Osteosarcoma
Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements.
The purpose of this trial is to investigate whether previously reported benefit of Tranexamic acid in pediatric orthopedic surgeries could be recapitulated in bone tumor surgeries or not through a double blinded randomized…
- Trial name
- NCT05024253
- Testing
- Tranexamic acid injection, Saline
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Children's Cancer Hospital Egypt 57357