Clinical trials: Tranexamic Acid Use
Subdural Hematoma
The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma
Subdural hematoma (SDH) is a common condition experienced after head injury. Blood collects on the surface of the brain, causing headaches which can progress to confusion, weakness, or even coma.
- Trial name
- TRACE (NCT05713630)
- Testing
- Tranexamic acid (TXA)
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Unity Health Toronto
Intraoperative Bleeding, Postoperative Edema
Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid
Purpose of the study: To evaluate the effect of tranexamic acid (TXA) of intraoperative blood loss in patients subjected to bi-maxillary orthognathic surgery To evaluate the potential effect of TXA on fibrin structure To evaluate…
- Trial name
- TXA2014-15 (NCT02229292)
- Testing
- Tranexamic Acid, Saline
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
This Study Will Evaluate Whether TXA Reduces Pain
Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial
To our knowledge, no studies examining the use of TXA after shoulder arthroscopy in an outpatient setting have been published. This study will evaluate whether TXA reduces pain as measured by opioid consumption and a visual…
- Trial name
- NCT06920264
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Louis Joint Replacement Institute
Blood Loss
Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty
This research study aims to study the use of tranexamic acid (TXA) in total joint replacement (arthroplasty) of the hip (THR) and knee (TKR).
- Trial name
- NCT03825939
- Testing
- Intravenous Tranexamic Acid
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Nephrolithiasis, Staghorn Calculus
Impact of Tranexamic Acid Use in Percutaneous Nephrolithotomy
This study is a double blinded randomized controlled trial evaluating the impact of tranexamic acid use on the transfusion rate in patients with complex kidney stones undergoing percutaneous nephrolithotomy.
- Trial name
- NCT02966236
- Testing
- Tranexamic Acid
- Where
- Brazil
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
vonWillebrand Disease, Hemophilia
The Use of Cyclokapron for Treatment and Management of Women With Bleeding Disorders
The high percentage of failure using available non-surgical options to treat menorrhagia in women with bleeding disorders shows a continuing need for innovative treatments.
- Conditions
- vonWillebrand Disease, Hemophilia, Platelet Coagulation Disorders
- Trial name
- NCT00697385
- Testing
- Cyclokapron
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mary M. Gooley Hemophilia Center
Obstetrical Hemorrhage
Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor?
Obstetrical hemorrhage accounts for nearly one quarter of all maternal deaths worldwide and was the most common cause of maternal death in the Turkey [1,2].
- Trial name
- NCT01338454
- Testing
- transamin
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Chronic Sinus Disease, Nasal Polyps
Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial
Functional Endoscopic Sinus surgery (FESS) is a surgery done for chronic rhinosinusitis after failure of medical treatment. Intraoperative bleeding poses a challenge to both the surgeon and anaesthetist.
- Trial name
- NCT03965767
- Testing
- Tranexamic Acid
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Cardiac Disease, Renal Disease
Pharmacokinetics of Tranexamic Acid in Patients With Varying Renal Function Undergoing Cardiac Surgery With the Use of Cardiopulmonary Bypass
Cardiopulmonary bypass surgery is associated with extensive blood loss in upto 20% of patients. Tranexamic acid (TXA) is a routinely administered antifibrinolytic agent that reduces blood loss and blood transfusion requirement.
- Trial name
- NCT01609686
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- University Health Network, Toronto
Percutaneous Nephrolithotomy, Intraoperative Use of Tranexamic Acid
Tranexamic Acid in Percutaneous Nephrolithotomy
Tranexamic acid, once a randomly used antifibrinolytic agent, has been in standard protocols for many specific surgeries. Studies are still needed to standardize the dose and route of tranexamic acid administration, examine its…
- Trial name
- NCT05947435
- Testing
- Tranexamic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Knee Osteoarthritis
Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients
The usefulness of tranexamic acid(TXA) to reduce blood loss and transfusion in total knee replacement arthroplasty(TKRA) has been demonstrated.
- Trial name
- NCT03109652
- Testing
- Tranexamic Acid
- Where
- South Korea
- Volunteers
- 144 people
- Sponsor
- Seoul National University Hospital
Fibroid Uterus, Abnormal Uterine Bleeding
Prophylactic Tranexamic Acid During Minimally Invasive Myomectomies
This is a Double-blinded randomized placebo-controlled trial based at Eastern Virginia Medical School. Subjects who are identified in clinic having menorrhagia or abnormal Uterine bleeding (AUB) due to uterine fibroids and meet…
- Conditions
- Fibroid Uterus, Abnormal Uterine Bleeding, Myoma;Uterus
- Trial name
- NCT04311073
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Blood Loss, Surgical
Use of Tranexamic Acid in Liposculpture
Blood loss during a surgical procedure is inevitable, its reduction is a key factor for surgical success. Also, to avoid progress to severe complications like hemodynamic decompensation, cardiac arrest or the need to blood…
- Trial name
- NCT04430777
- Testing
- Tranexamic acid
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Total Definer Research Group
Blood Loss, Hemoglobin Change
Prospective Investigation of Intra-Articular Tranexamic Acid Use in Elective Hip Arthroplasty
Tranexamic acid (trans-4-aminomethyl cyclohexane carboxylic acid) is an antifibrinolytic substance that chemically belongs to the group of e-carboxylic acids.
- Conditions
- Blood Loss, Hemoglobin Change, Blood Transfusion, Heterotopic Ossification
- Trial name
- NCT06903299
- Testing
- Intra-articular Tranexamic acid application
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Hematoma Postoperative, Tranexamic Acid
Topical Tranexamic Acid for Bilateral Breast Reduction Surgery
Hematoma is a common complication of bilateral breast reduction (BBR) surgery. This can lead to pain and discomfort experienced by the patient, in addition to greater use of valuable healthcare resources.
- Trial name
- NCT04918576
- Testing
- Tranexamic acid, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- McMaster University
Gastric Polyp, Gastric Neoplasm
Tranexamic Acid During Upper GI Endoscopic Resection Procedures
Endoscopic resection of gastrointestinal lesions may prevent cancer. However, resection is associated with adverse events such as bleeding.
- Conditions
- Gastric Polyp, Gastric Neoplasm, Duodenal Neoplasms, Esophageal Neoplasms
- Trial name
- NCT05688020
- Testing
- Tranexamic acid, Epinephrine injection
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Breast Cancer, BRCA Mutation
Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage
Tranexamic acid (TxA) is a drug that was approved by the FDA in 1986. It is an antifibrinolytic drug - this means that it is used to promote blood clotting by preventing the breakdown of blood clots that the participant's body…
- Trial name
- NCT05554211
- Testing
- Tranexamic acid, Normal saline
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Tonsillectomy, Adenoidectomy
Tranexamic Acid and Pediatric Adenotonsillectomy
The purpose of this study is to determine if the use of tranexamic acid prior adenotonsillectomy in children can reduce surgical and postoperative bleeding.
- Conditions
- Tonsillectomy, Adenoidectomy, Tranexamic Acid
- Trial name
- NCT01228136
- Testing
- Tranexamic Acid, normal saline solution
- Where
- Brazil
- Volunteers
- 95 people
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre
Shoulder Joint Disease, Complications; Arthroplasty
Tranexamic Acid in Reverse Total Shoulder Arthroplasty
To the Investigators' knowledge, TXA has not been studied in the setting of reverse total shoulder arthroplasty. We propose a double-blinded, randomized, controlled trial comparing perioperative administration of TXA to placebo…
- Conditions
- Shoulder Joint Disease, Complications; Arthroplasty, Intraoperative Complications, Blood Loss, Surgical
- Trial name
- TXA (NCT02043132)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Corewell Health East
Hemorrhage, Fracture Femur
Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA
An intertrochanteric (ITF) trochanteric fracture of the femur is an exclusively extra capsular fracture in which the fracture line extends from the greater trochanter to the lesser trochanter.
- Trial name
- NCT04696224
- Testing
- Tranexamic acid, Saline solution
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai