Clinical trials: Toxicity
Cancer, Breast, Cancer Colorectal
Interventions to Decrease Financial Toxicity
Financial distress affects 30-70% of cancer patients and describes the burden that patients experience due to the costs of care (CoC).
- Conditions
- Cancer, Breast, Cancer Colorectal, Cancer, Ovarian, Cervical Cancer
- Trial name
- P-COC (NCT05939440)
- Testing
- Proactive Cost of Care (P-COC) intervention, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Arsenic Poisoning, Toxic Effect of Arsenic and Its Compounds
Effects of Folic Acid Supplementation on Arsenic Lowering
The purpose of this study is to determine whether folic acid supplementation are effective on arsenic lowering in a chronic, low-level arsenic exposed population.
- Trial name
- NCT02235948
- Testing
- folic acid supplementation
- Volunteers
- 450 people
- Sponsor
- Wenzhou Medical University
Solid Tumors, Hematologic Neoplasms
Allogeneic Hematopoietic Stem Cell Transplantation
To assess the engraftment of hematopoietic stem cells following reduced-intensity conditioning in children presenting with solid tumors or hematological malignancy by evaluating post-transplantation chimerism and hematological…
- Trial name
- RICE (NCT00750126)
- Testing
- Fludarabine, Busulfan, Thymoglobulin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Nicotine Dependence, Tobacco Toxicity
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine…
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
- Trial name
- SREC22 (NCT05658471)
- Testing
- Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glioblastoma Multiforme
Open-Label Pilot Study of OPTUNE® With High Density Transducer Arrays for the Treatment of Recurrent GBM
This is a prospective, open-label, single arm, historical control pilot study aimed to test the effectiveness and safety of TTFields delivered through high intensity arrays in recurrent glioblastoma.
- Trial name
- NCT04492163
- Testing
- TTFields
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- NovoCure GmbH
Kidney Cancer, Renal Cell Carcinoma Metastatic
TDM for Optimized Outcome in Patients With mRCC.
The purpose of this observational study is to assess the role of plasma concentration monitoring of treatment drugs for patients with metastatic renal cell carcinoma (mRCC) in terms of efficacy and side effects.
- Conditions
- Kidney Cancer, Renal Cell Carcinoma Metastatic, Drug Toxicity, Drug Side Effect
- Trial name
- NCT04659343
- Testing
- Measurement of concentration of active metabolite in cancer treatment.
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Niels Fristrup
Hodgkin Lymphoma
Gonadal Toxicity in Women With Hodgkin Lymphoma
The Gruppo Italiano Studio Linfomi has been collecting data on patients with Hodgkin Lymphoma (HL) since 1988. This archive represents a homogeneous series of consecutive patients with HL.
- Trial name
- FertHD (NCT01008735)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Gruppo Italiano Studio Linfomi
Human Immunodeficiency Virus
Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa
The two original objectives were to determine in HIV-infected children initiating antiretroviral therapy (ART): 1. Whether clinically driven monitoring (CDM) will have a similar outcome in terms of disease progression or death as…
- Trial name
- ARROW (NCT02028676)
- Testing
- Clinically Driven Monitoring (CDM), Laboratory plus Clinical Monitoring (LCM), Arm A: ABC+3TC+NNRTI
- Where
- 4 sites in Uganda, Zimbabwe
- Volunteers
- 1,206 people
- Sponsor
- Medical Research Council
Cytomegalovirus Disease, Cytomegalovirus Infections
Letermovir Use in Heart Transplant Recipients
This is an open label trial in which letermovir will be given as prophylaxis for the prevention of cytomegalovirus (CMV) infection and disease to all heart transplants who are at risk for cytomegalovirus.
- Conditions
- Cytomegalovirus Disease, Cytomegalovirus Infections, Heart Transplant Infection, Antiviral Toxicity
- Trial name
- NCT04904614
- Testing
- Letermovir
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tufts Medical Center
Head and Neck Cancer
Navigation on Head and Neck Radiotherapy
The aim of this experimental study is to evaluate the effect of nurse navigation in the management of symptoms associated with head and neck radiotherapy.
- Trial name
- NCT04857749
- Testing
- Standard care, Navigation Nursing
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Selcuk University
Colorectal Cancer Metastatic, Skin Toxicity
Panitumumab Skin Toxicity Prevention Trial
Background and rationale: EGFR represents the main and more studied signal activation pathway in the development of colorectal carcinoma.
- Trial name
- PaSTo (NCT03167268)
- Testing
- Lycopene
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Ospedale San Carlo Borromeo
Leukemia, Acute Lymphoblastic, Lymphoblastic Leukemia, Acute, Childhood
CAR-Multicenter Analysis (CAR-MA): Retrospective Study to Characterize CAR T-cell Outcomes and Related Toxicities in Children and Young Adults With B-ALL
Study Description: This retrospective protocol focuses on characterizing clinical outcomes and toxicities following CAR T-cell therapy.
- Trial name
- NCT05440409
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Safety Issues, Anticoagulant Toxicity
Clinical Pharmacist Anticoagulant Stewardship
Initiative to improve direct anticoagulant utilization involving programmatic review by clinical pharmacists in collaboration with multidisciplinary team.
- Trial name
- NCT03527615
- Testing
- Clinical Pharmacist Medication Review
- Where
- Israel
- Volunteers
- 4,000 people
- Sponsor
- Hadassah Medical Organization
Cancer
Quality of Life and Economic Repercussions of Combining Proactive Medication Assessment and Electronic Monitoring of Toxicities in Subjects Undergoing Oral Cancer Therapy
Therapies used to treat cancer are administered orally (OT) in 75% of cases, lending themselves to outpatient care. This care pathway raises new issues: specific toxicities, drug interactions, and the relationship between the…
- Trial name
- PROLIFE (NCT05345587)
- Testing
- THESS monitoring
- Where
- 6 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity
Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline
In recent decades, the survival rate of children with cancer has increased significantly thanks to personalized treatments and the adoption of international therapeutic protocols.
- Conditions
- Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity, Childhood Cancer Survivors
- Trial name
- CARDIO-PED (NCT07253077)
- Testing
- Biomarker detection
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Disinfectant Causing Toxic Effect
A Comparative Study Between Honey and Alcohol as Topical Skin Disinfectant
Skin antisepsis is essential in every healthcare environment. Alcohol/chlorhexidine use might disrupt skin microbiota and lead to antibiotic resistance.
- Trial name
- NCT05937412
- Testing
- Alcohol sterilization, Honey sterilization
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Kidney Diseases, Heart Transplantation
Safe Renal Function In Long Term Heart Transplanted Patients
The purpose of this study is to verify whether the reduction of cyclosporine dosages associated with Everolimus administration may improve renal function as compared to patients maintained on standard immunosuppressive therapy
- Trial name
- SAREFU (NCT00505102)
- Testing
- Everolimus
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Resistance Training, Colon Cancer
FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study
FORCE is a randomized home-based resistance training/strength training (RT) intervention study for Stage II and III colon cancer patients undergoing chemotherapy.
- Conditions
- Resistance Training, Colon Cancer, Chemotherapy Effect
- Trial name
- FORCE (NCT03291951)
- Testing
- Resistance training
- Where
- 3 sites in United States
- Volunteers
- 183 people
- Sponsor
- Kaiser Permanente
Head and Neck Cancer, Radiotherapy
Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer
The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT).
- Trial name
- ROOCT (NCT04610645)
- Testing
- OCT, Dermatoscope
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Bone Marrow Suppression, Brain and Central Nervous System Tumors
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, etoposide phosphate, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bone Marrow Suppression, Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00238173
- Testing
- filgrastim, acetylcysteine, carboplatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute