Clinical trials: Toxicity, Drug
Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
This is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.
- Conditions
- Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum, Sjogren Syndrome, Mucous Membrane Pemphigoid
- Trial name
- NCT03839069
- Testing
- minor salivary gland transplantation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Cancer, Neoplasms
Mobile Health Intervention to Improve Adherence to Oral Anticancer Therapy
New oral anticancer treatments have improved survival across cancer types but introduced challenges in medication adherence and symptom management.
- Trial name
- SMART pilot (NCT07073807)
- Testing
- SMART Intervention using TAPPT® for Adherence, Symptom, Financial, and Social Needs Monitoring
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of California, Irvine
Breast Cancer, Neoplasm, Breast
Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
Breast cancer is the most commonly cancer in women in the overall global population. According to the World Cancer Research Fund International, there were more than 2.25 million new cases of breast cancer in women in 2020.
- Conditions
- Breast Cancer, Neoplasm, Breast, Breast Diseases, Antihypertensive Agents
- Trial name
- NCT05465031
- Testing
- Sacubitril-valsartan
- Where
- 4 sites in Poland
- Volunteers
- 600 people
- Sponsor
- Silesian Centre for Heart Diseases
Acute Kidney Injury, Drug Use
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
This observational retrospective study aims to learn about the incidence of acute kidney (AKI) injury in newborns in infants exposed to nephrotoxic drugs with a big data approach.
- Conditions
- Acute Kidney Injury, Drug Use, Drug Interaction, Drug Toxicity
- Trial name
- NeoAKISTOP (NCT05851222)
- Where
- Italy
- Volunteers
- 4,200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Anemia, Breast Cancer
Epoetin Alfa in Treating Anemia in Patients Who Are Receiving Chemotherapy
RATIONALE: Epoetin alfa may stimulate red blood cell production and treat anemia in patients with cancer who are receiving chemotherapy.
- Conditions
- Anemia, Breast Cancer, Chronic Myeloproliferative Disorders, Drug/Agent Toxicity by Tissue/Organ
- Trial name
- NCT00003600
- Testing
- epoetin alfa
- Where
- 21 sites in United States, Canada
- Volunteers
- 344 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Childhood Cancer, Cardiac Toxicity
Translating ECHOS2 Into an mHealth Platform
Childhood cancer survivors are at an increased risk of cardiac toxicity due to prior anti-cancer therapy. However, adherence to cardiac screening in this population remains low.
- Conditions
- Childhood Cancer, Cardiac Toxicity, Pediatric Cancer
- Trial name
- ECHOS2 (NCT05923242)
- Testing
- Computerized Intervention Authoring Software (CIAS)
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Washington University School of Medicine
Hepatitis C, Chronic
An Observational Study of the Safety of Direct-acting Antivirals in Patients With Hepatitis C
The investigators will assess whether patients with the Hepatitis C virus (HCV) who are prescribed direct-acting antiviral (DAA) medications experience higher rates of adverse events than patients with HCV who are untreated.
- Trial name
- NCT03423641
- Testing
- Direct Acting Antivirals
- Volunteers
- 33,808 people
- Sponsor
- Kaiser Permanente
Motivational Interview, Cosmetic Product Causing Toxic Effect
The Effectiveness of Motivational Interviewing in Reducing the Use of Household Chemicals and Personal Care Products During Pregnancy
Objective: The aim of the study is to examine the effect of motivational interviewing on reducing the use of household chemicals and personal care products during pregnancy.
- Trial name
- NCT06380634
- Testing
- Experimental group- Motivational Interview
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Combination Chemotherapy After Surgery With or Without Chinese Herbal Therapy to Treat Symptoms in Women With Breast Cancer
RATIONALE: Herbs used in traditional Chinese medicine may decrease the side effects of chemotherapy. PURPOSE: Randomized phase I/II trial to study the effectiveness of herbs used in traditional Chinese medicine in decreasing the…
- Trial name
- NCT00028964
- Testing
- Chinese herbs, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Sponsor
- University of California, San Francisco
Small Cell Lung Cancer
G-Step: Gemcitabine Based Small-cell Lung Cancer Treatment in Elderly Patients
The purpose of this study is to describe the activity and toxicity of gemcitabine combined with four different drugs (carboplatin or cisplatin or etoposide or vinorelbine) as first line treatment of elderly patients with…
- Trial name
- G-Step (NCT00401609)
- Testing
- gemcitabine, vinorelbine, cisplatin
- Where
- 21 sites in Italy
- Volunteers
- 85 people
- Sponsor
- National Cancer Institute, Naples
Breast Cancer, Peripheral Neuropathy
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
Aim of the work This study aims to evaluate the possible beneficial role of silymarin in attenuating both doxorubicin related cardiac and hepatic toxicities and paclitaxel associated peripheral neuropathy and improving cognitive…
- Conditions
- Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity
- Trial name
- NCT05595109
- Testing
- Silymarin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
Breast Cancer, Paclitaxel Adverse Reaction
Investigating Paclitaxel Toxicity in Breast Cancer: the Roles of Physical Activity and Body Composition.
This study looks into how a common breast cancer treatment, paclitaxel, can sometimes cause severe side effects that make it hard for patients to continue treatment.
- Conditions
- Breast Cancer, Paclitaxel Adverse Reaction, Chemotherapeutic Toxicity, Chemotherapeutic Agent Toxicity
- Trial name
- PABTOX (NCT06387901)
- Testing
- Paclitaxel Chemotherapy
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Osteosarcoma, Survival
Comparison of MAPI+Camrelizumab Versus API+Apatinib Versus MAPI in Patients With a Poor Response to Preoperative Chemotherapy for Newly Diagnosed High-grade Osteosarcoma
Treatment strategies for high-grade osteosarcoma with multidrug chemotherapy and resection result in 3-year event-free survival of 60-70%.
- Conditions
- Osteosarcoma, Survival, Chemotherapy Effect, Toxicity, Drug
- Trial name
- MAPAC (NCT04351308)
- Testing
- MAPI chemotherapy, Apatinib Mesylate, Camrelizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Acute Kidney Injury, Beta-Lactam Antibiotic Toxicity (Diagnosis)
Risk Factors and Machine Learning Model for Beta-Lactam Drugs Related Acute Kidney Injury
Acute kidney injury (AKI), also known as acute kidney failure (ARF), is a common and complex kidney disease in clinic and an important factor related to poor prognosis of patients in clinic.
- Trial name
- NCT05533606
- Testing
- Beta-Lactam Drugs
- Where
- China
- Volunteers
- 19,000 people
- Sponsor
- Qianfoshan Hospital
Colon Cancer, Colon Diverticulosis
Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
The General Objective of this study is to investigate the cost and efficacy of treating patients undergoing colorectal surgical resections with an opioid limited pain control regimen as part of an Enhanced Recovery After Surgery…
- Conditions
- Colon Cancer, Colon Diverticulosis, Colonic Neoplasms, Colonic Diverticulitis
- Trial name
- NCT02958566
- Testing
- Acetaminophen, Gabapentin, Orphenadrine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois College of Medicine at Peoria
Critical Illness, Antibiotic Toxicity
Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients
Although alternative dosing strategies can improve antimicrobial exposure in critically ill patients, the high PK variability in this population means that some may still receive sub-optimal antibiotic exposure leading to…
- Conditions
- Critical Illness, Antibiotic Toxicity, Sepsis, Septic Shock
- Trial name
- DOSATB (NCT04530045)
- Testing
- dosage of concentration of piperacillin and cefepim
- Where
- 2 sites in France
- Volunteers
- 99 people
- Sponsor
- Central Hospital, Nancy, France
Breast Cancer, Cardiac Toxicity
BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study
Breast radiotherapy RT used until the 1990s was clearly responsible for increased mortality due to long term cardiac complications.
- Trial name
- BACCARAT (NCT02605512)
- Testing
- Subclinical cardiac lesions and biomarkers
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Sophie JACOB
Drug/Agent Toxicity by Tissue/Organ, Testicular Germ Cell Tumor
Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles
RATIONALE: Drugs used in chemotherapy, such as bleomycin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00324298
- Testing
- bleomycin sulfate, cisplatin, etoposide
- Where
- 10 sites in United Kingdom
- Volunteers
- 210 people
- Sponsor
- Queen Mary University of London
Arthritis, Systemic Lupus Erythematosus
Monitoring the IMmUological TOXicity of Drugs
Several drugs and chemotherapies seem to have an impact on the immunological system. This study investigates reports of immunological toxicities, including the International classification of disease ICD-10 codes M05, M32, I78…
- Conditions
- Arthritis, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Capillary Leak Syndrome
- Trial name
- MIMUTOX (NCT03480529)
- Testing
- drug inducing arthritis, lupus, hepatitis, or capillary leak syndrom
- Where
- 2 sites in France
- Volunteers
- 662 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Chemotherapeutic Agent Toxicity, Renal Toxicity
Kidney Damage in Patients Receiving Cisplatin and Ifosfamide for Solid Tumors
RATIONALE: Studying samples of blood and urine from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Conditions
- Chemotherapeutic Agent Toxicity, Renal Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00695032
- Testing
- cisplatin, ifosfamide, laboratory biomarker analysis
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut Claudius Regaud